Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease activity in rheumatoid arthritis
Version of Record online: 30 APR 2012
Copyright © 1993 American College of Rheumatology
Arthritis & Rheumatism
Volume 36, Issue 2, pages 199–203, February 1993
How to Cite
Harrington, L., Affleck, G., Urrows, S., Tennen, H., Higgins, P., Zautra, A. and Hoffman, S. (1993), Temporal covariation of soluble interleukin-2 receptor levels, daily stress, and disease activity in rheumatoid arthritis. Arthritis & Rheumatism, 36: 199–203. doi: 10.1002/art.1780360209
- Issue online: 30 APR 2012
- Version of Record online: 30 APR 2012
- Manuscript Accepted: 14 JUL 1992
- Multipurpose Arthritis Center. Grant Number: AM-20621
Objective. To examine synchronous changes in soluble interleukin-2 receptor (sIL-2R) levels, daily indicators of emotional stress, joint inflammation, and reported pain in patients with rheumatoid arthritis (RA).
Methods. Fourteen patients were studied on each of 6 occasions, 2 weeks apart. Measures included daily ratings of mood disturbance, undesirable events, and joint pain; clinical examination of joint swelling; and serum assays of sIL-2R. Pooled within-person correlations among these variables were calculated.
Results. Consistent with the results of previous research, joint inflammation covaried directly with sIL-2R levels. Changes in mood disturbance were unrelated to changes in joint inflammation, but increases in mood disturbance were linked with decreases in sIL-2R levels and increases in reported joint pain.
Conclusion. These findings provide preliminary evidence that psychoimmune processes may be implicated in short-term changes in RA disease activity.