Cancer in systemic sclerosis

Authors

  • Mahmoud Abu-Shakra MD,

    1. University of Toronto, Rheumatic Disease Unit, and The Wellesley Hospital, Toronto, Ontario, Canada.
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  • Francis Guillemin MD,

    1. University of Toronto, Rheumatic Disease Unit, and The Wellesley Hospital, Toronto, Ontario, Canada.
    2. School of Public Health, Faculty of Medicine, Nancy, France
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  • Peter Lee MD

    Associate Professor of Medicine, Corresponding author
    1. University of Toronto, Rheumatic Disease Unit, and The Wellesley Hospital, Toronto, Ontario, Canada.
    Current affiliation:
    1. The Wellesley Hospital
    • The Wellesley Hospital, 160 Wellesley Street East, 421 Jones Building, Toronto, Ontario M4Y 1J3, Canada
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Abstract

Objective. To determine whether the frequency of cancer is increased among patients with systemic sclerosis (SSc).

Methods. A retrospective chart review of 248 patients who were followed up prospectively was conducted.

Results. Cancers developed in 18 patients (7.3%) during 2,001 patient-years at risk. The most frequent types were cancers of the lung (7 patients) and breast (5 patients). Older age at diagnosis of SSc was a significant risk factor for cancer. Lung cancer was associated with the presence of pulmonary fibrosis. The age-standardized incidence rate for all cancers (7.9/1,000) was 2.1 times the overall rate in the Ontario population (P > 0.0001).

Conclusion. The frequency of cancer is increased in patients with SSc.

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