Association of hla–dr4-dw15 (drb1*0405) and dr10 with rheumatoid arthritis in a spanish population
Article first published online: 9 DEC 2005
Copyright © 1993 American College of Rheumatology
Arthritis & Rheumatism
Volume 36, Issue 6, pages 811–814, June 1993
How to Cite
Yelamos, J., Raül Garcia-Lozano, J., Moreno, I., Aguilera, I., Francisca Gonzalez, M., Garcia, A., Nuñez-Roldan, A. and Sanchez, B. (1993), Association of hla–dr4-dw15 (drb1*0405) and dr10 with rheumatoid arthritis in a spanish population. Arthritis & Rheumatism, 36: 811–814. doi: 10.1002/art.1780360611
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Accepted: 26 JAN 1993
- Manuscript Received: 25 AUG 1992
- CYCIT. Grant Number: BIO 89/0043
- Ministerio de Sanidad y Conσumo
- Fondo de Investigaciones Sanitarias. Grant Number: FIS 90/0053
Objective. To analyze the associations of HLA class II antigens with rheumatoid arthritis (RA) in a Spanish population.
Methods. We used DNA oligotyping to determine DR types, DQA1 and DQB1 alleles, and DR4 variants in 70 unrelated seropositive RA patients and 189 healthy controls living in Spain.
Results. A significantly higher frequency of DR4 was seen in RA patients compared with controls (relative risk [RR] = 2.40). The DR10 specificity correlated most strongly with disease susceptibility (RR = 3.84). A significant decrease in the frequency of DR7 was observed in the RA patients (RR = 0.48). DR4-Dw15 (DRB1*0405) was found to be the unique DR4 allele associated with RA (RR = 4.27, P < 0.05), whereas Dw4 (DRB1*0401) and Dw14 (DRB1*0404/0408) showed no association, and both D10 (DRB1*0402) and Dw13 (DRB1*0403/0407) were negative risk factors for the disease. Approximately one-third of the cases of RA could not be explained by the “shared epitope” hypothesis. Investigation of the DQ alleles associated with DR4 showed that the haplotype Dw15-DQ8 (DRB1*0405-DQB1*0302) was a susceptibility factor for RA (RR = 6.36, P < 0.05).
Conclusion. Our results suggest that HLA class II alleles involved in RA susceptibility can vary among different Caucasian populations.