Autoantibodies to chromatin components in juvenile rheumatoid arthritis
Article first published online: 9 DEC 2005
Copyright © 1993 American College of Rheumatology
Arthritis & Rheumatism
Volume 36, Issue 6, pages 836–841, June 1993
How to Cite
Burlingame, R. W., Rubin, R. L. and Rosenberg, A. M. (1993), Autoantibodies to chromatin components in juvenile rheumatoid arthritis. Arthritis & Rheumatism, 36: 836–841. doi: 10.1002/art.1780360615
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Accepted: 29 DEC 1992
- Manuscript Received: 6 AUG 1992
- NIH. Grant Number: AR-34358
Objective. To characterize autoantibodies to chromatin components in patients with juvenile rheumatoid arthritis (JRA).
Methods. The sera of 50 children with JRA were analyzed for antinuclear antibodies (ANA) by immunofluorescence and enzyme-linked immunosorbent assay (ELISA) techniques.
Results. By immunofluorescence, ANA and antibodies to high-mobility group proteins or to DNA-free histones were common in patients with pauciarticular JRA and rheumatoid factor–positive polyarticular JRA. However, reactivity with histone–DNA complexes was rare.
Conclusion. Because antihistone antibodies detected by ELISA failed to bind chromatin or other histone–DNA complexes, they are not likely to represent the immunofluorescent ANA activity in serum.