Causes of death in systemic lupus erythematosus, long-term followup of an inception cohort
Article first published online: 9 DEC 2005
Copyright © 1995 American College of Rheumatology
Arthritis & Rheumatism
Volume 38, Issue 10, pages 1492–1499, October 1995
How to Cite
Ward, M. M., Pyun, E. and Studenski, S. (1995), Causes of death in systemic lupus erythematosus, long-term followup of an inception cohort. Arthritis & Rheumatism, 38: 1492–1499. doi: 10.1002/art.1780381016
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Revised: 31 MAY 1995
- Manuscript Accepted: 31 MAY 1995
- Manuscript Received: 20 JAN 1995
- Maudie Long Gift Fund
Objective. To describe the causes of death in a cohort of patients with systemic lupus erythematosus (SLE), and to determine if the major causes of death differ according to patient age, sex, race, socioeconomic status, and the duration of SLE.
Methods. We examined survival in a cohort of 408 patients with SLE. During a median of 11 years of followup, 144 patients died. The cause of death was determined for 134 patients (93%).
Results. SLE was the most common cause of death, occurring in 49 patients (34%), followed by in- fection (n = 32; 22%), cardiovascular disease (n = 23; 16%), cerebrovascular disease (n = 8; 6%), and cancer (n = 8; 6%). Deaths due to SLE and due to infections were more common among younger patients, and deaths due to cancer were more common among older patients. Although the risk of death due to SLE was greatest during the first 3 years after diagnosis, deaths due to SLE occurred throughout the course of disease.
Conclusion. In this study of patients with SLE who were followed up for an extended period of time beginning soon after diagnosis, SLE was the most common cause of death, and deaths due to SLE occurred throughout the course of illness.