Risk factors for septic arthritis in patients with joint disease
Article first published online: 9 DEC 2005
Copyright © 1995 American College of Rheumatology
Arthritis & Rheumatism
Volume 38, Issue 12, pages 1819–1825, December 1995
How to Cite
Kaandorp, C. J. E., Schaardenburg, D. V., Krijnen, P., Habbema, J. D. F. and Van De Laar, M. A. F. J. (1995), Risk factors for septic arthritis in patients with joint disease. Arthritis & Rheumatism, 38: 1819–1825. doi: 10.1002/art.1780381215
- Issue published online: 9 DEC 2005
- Article first published online: 9 DEC 2005
- Manuscript Revised: 20 JUN 1995
- Manuscript Accepted: 20 JUN 1995
- Manuscript Received: 22 MAR 1995
- Dutch Prevention Fund. Grant Number: 28–1879
Objective. To quantify potential risk factors for septic arthritis, in order to identify a basis for prevention.
Methods. The occurrence of potential risk factors for septic arthritis in patients with joint diseases attending a rheumatic disease clinic was prospectively monitored at 3-m onth intervals over a period of 3 years. Potential risk factors investigated were type of joint disease, comorbidity, medication, joint prosthesis, infections, and invasive procedures. The frequencies of risk factors in patients with and those without septic arthritis were compared using multiple logistic regression analysis.
Results. There were 37 patients with and 4,870 without septic arthritis. Risk factors for developing septic arthritis were age ≥80 years (odds ratio [OR] = 3.5, 95% confidence interval [95% CI] 1.4–8.6), diabetes mellitus (OR = 3.3, 95% CI 1.1–10.1), rheumatoid arthritis (OR = 4.0, 95% CI 1.9–8.3), hip and/or knee prosthesis (OR = 15, 95% CI 4.1–54.3), joint surgery (OR = 5.1, 95% CI 2.2–11.9), and skin infection (OR = 27.2, 95% CI 7.6–97.1)
Conclusion. These findings indicate that preventive measures against septic arthritis in patients with joint diseases should mainly be directed at those with joint prostheses and/or skin infection.