The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus
Article first published online: 15 DEC 2005
Copyright © 1996 American College of Rheumatology
Arthritis & Rheumatism
Volume 39, Issue 3, pages 363–369, March 1996
How to Cite
Gladman, D., Ginzler, E., Goldsmith, C., Fortin, P., Liang, M., Sanchez-Guerrero, J., Urowitz, M., Bacon, P., Bombardieri, S., Hanly, J., Jones, J., Hay, E., Symmons, D., Isenberg, D., Kalunion, K., Maddison, P., Nived, O., Sturfelt, G., Petri, M., Richter, M., Snaith, M. and Zoma, A. (1996), The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus. Arthritis & Rheumatism, 39: 363–369. doi: 10.1002/art.1780390303
- Issue published online: 15 DEC 2005
- Article first published online: 15 DEC 2005
- Manuscript Accepted: 21 JUL 1995
- Manuscript Received: 6 SEP 1994
- Syntex Pharmaceutical and the American College of Rheumatology
Objective. To develop and perform an initial validation of a damage index for systemic lupus erythematosus (SLE).
Methods. A list of items considered to reflect damage in SLE was generated through a nominal group process. A consensus as to which items to be included in an index was reached, together with rules for ascertainment. Each center submitted 2 assessments, 5 years apart, on 2 patients with active and 2 with inactive disease, of whom 1 had increased damage and the other had stable disease. Analysis of variance was used to test the factors physician, time, amount of damage, and activity status.
Results. Nineteen physicians completed the damage index on 42 case scenarios. The analysis revealed that the damage index could identify changes in damage seen in patients with both active and inactive disease. Patients who had active disease at both time points had a higher increase in damage. There was good agreement among the physicians on the assessment of damage in these patients.
Conclusion. This damage index for SLE records damage occurring in patients with SLE regardless of its cause. The index was demonstrated to have content, face, criterion, and discriminant validity.