The effect of progressive resistance training in rheumatoid arthritis. Increased strength without changes in energy balance or body composition

Authors

  • Laura C. Rall PhD, RD,

    1. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
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  • Simin Nikbin Meydani DVM, PhD,

    1. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
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  • Joseph J. Kehayias PhD,

    1. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
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  • Bess Dawson-Hughes MD,

    1. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts
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  • Ronenn Roubenoff MD, MHS

    Corresponding author
    1. Jean Mayer USDA Human Nutrition Research Center on Aging, and the Tupper Research Institute, New England Medical Center, Boston, Massachusetts
    • JMUSDA-HNRCA at Tufts University, 711 Washington Street, Boston, MA 02111
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Abstract

Objective. To demonstrate the feasibility of high-intensity progressive resistance training in rheumatoid arthritis (RA) patients compared with healthy control subjects.

Methods. Eight subjects with RA, 8 healthy young subjects, and 8 healthy elderly subjects underwent 12 weeks of high-intensity progressive resistance training, while 6 elderly subjects performed warm-up exercises only. Fitness, body composition, energy expenditure, function, disease activity, pain, and fatigue were measured at baseline and followup.

Results. All 3 training groups demonstrated similar improvements in strength compared with the change among control subjects (RA group 57% [P < 0.0005], young exercise group 44% [P < 0.01], elderly exercise group 36% [P < 0.05]). Subjects with RA had no change in the number of painful or swollen joints but had significant reductions in self-reported pain score (21% [P < 0.05]) and fatigue score (38% [P = 0.06]), improved 50-foot walking times (mean ± SD 10.4 ± 2.2 seconds versus 8.3 ± 1.5 seconds [P < 0.005]), and improved balance and gait scores (48.9 ± 3.8 versus 50.4 ± 2.0 [P = 0.07]).

Conclusion. High-intensity strength training is feasible and safe in selected patients with well-controlled RA and leads to significant improvements in strength, pain, and fatigue without exacerbating disease activity or joint pain.

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