Early expression of E-selectin, tumor necrosis factor α, and mast cell infiltration in the salivary glands of patients with systemic sclerosis
Version of Record online: 12 DEC 2005
Copyright © 1996 American College of Rheumatology
Arthritis & Rheumatism
Volume 39, Issue 7, pages 1161–1165, July 1996
How to Cite
Hebbar, M., Gillot, J.-M., Hachulla, E., Lassalle, P., Hatron, P.-Y., Devulder, B. and Janin, A. (1996), Early expression of E-selectin, tumor necrosis factor α, and mast cell infiltration in the salivary glands of patients with systemic sclerosis. Arthritis & Rheumatism, 39: 1161–1165. doi: 10.1002/art.1780390713
- Issue online: 12 DEC 2005
- Version of Record online: 12 DEC 2005
- Manuscript Accepted: 20 FEB 1996
- Manuscript Received: 23 OCT 1995
Objective. To assess the predictive value of early endothelial E-selectin and tumor necrosis factor α (TNFα) expression, as well as mast cell infiltration, in the subsequent progression to systemic sclerosis (SSc) in patients with Raynaud's phenomenon (RP) and abnormal nailfold capillaroscopic findings.
Methods. Clinical criteria were evaluated, and immunostaining was performed on lip biopsy samples from 22 patients with RP and abnormal capillaroscopic results. None of these patients initially fulfilled the American College of Rheumatology criteria for SSc.
Results. E-selectin, TNFα, and mast cell infiltration were found in 9, 10, and 8 of 11 patients, respectively, whose disease progressed to SSc, and in 0, 2, and 1 of 11 patients, respectively, whose disease did not progress to SSc (P < 0.001, P < 0.01, and P < 0.01, respectively).
Conclusion. E-selectin, TNFα, and mast cell infiltration are detectable in the very early stages of SSc, prior to the onset of skin changes.