Antibodies to type II collagen in early rheumatoid arthritis. Correlation with disease progression
Article first published online: 12 DEC 2005
Copyright © 1996 American College of Rheumatology
Arthritis & Rheumatism
Volume 39, Issue 10, pages 1720–1727, October 1996
How to Cite
Cook, A. D., Rowley, M. J., Mackay, I. R., Gough, A. and Emery, P. (1996), Antibodies to type II collagen in early rheumatoid arthritis. Correlation with disease progression. Arthritis & Rheumatism, 39: 1720–1727. doi: 10.1002/art.1780391015
- Issue published online: 12 DEC 2005
- Article first published online: 12 DEC 2005
- Manuscript Accepted: 24 APR 1996
- Manuscript Received: 6 NOV 1995
Objective. To establish that frequencies and levels of IgG antibodies to type II collagen are higher in early rheumatoid arthritis (RA), and to correlate these results with disease activity.
Methods. Forty-four patients were characterized as having early RA. Patient sera obtained at initial presentation and at 12 months were tested by enzyme-linked immunosorbent assay for IgG antibodies to native and denatured type II collagen.
Results. IgG antibodies to native and denatured type II collagen were detected at initial presentation in 27% and 82% of patients, respectively, and after 12 months in 14% and 50%, respectively. The presence of antibodies to native collagen was associated with activity of RA and severity of symptoms, and loss of antibodies at 12 months was associated with initially erosive RA and the DRB1 disease susceptibility motif.
Conclusion. Levels of serum IgG antibodies to collagen in RA decrease over time and, therefore, are not attributable simply to cartilage destruction. The presence of early positivity for these antibodies, together with the RA susceptibility motif, appears to be predictive of rapidly progressive RA.