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Clinical Science

Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double-blind, placebo-controlled trial

  1. James R. O'Dell MD1,*,
  2. Claire E. Haire RN, MSN2,
  3. William Palmer MD3,
  4. Walter Drymalski MD4,
  5. Steven Wees MD5,
  6. Kent Blakely MD6,
  7. Melvin Churchill MD7,
  8. P. James Eckhoff MD8,
  9. Arthur Weaver MD9,
  10. Deborah Doud MD10,
  11. Nils Erikson MD11,
  12. Fred Dietz MD12,
  13. Rich Olson MD13,
  14. Pierre Maloley PharmD2,
  15. Lynell W. Klassen MD1,
  16. Gerald F. Moore MD2

Article first published online: 12 DEC 2005

DOI: 10.1002/art.1780400510

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 40, Issue 5, pages 842–848, May 1997

Additional Information

How to Cite

O'Dell, J. R., Haire, C. E., Palmer, W., Drymalski, W., Wees, S., Blakely, K., Churchill, M., Eckhoff, P. J., Weaver, A., Doud, D., Erikson, N., Dietz, F., Olson, R., Maloley, P., Klassen, L. W. and Moore, G. F. (1997), Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double-blind, placebo-controlled trial. Arthritis & Rheumatism, 40: 842–848. doi: 10.1002/art.1780400510

Author Information

  1. 1

    University of Nebraska Medical Center and Omaha VA Hospital, Omaha, Nebraska

  2. 2

    University of Nebraska Medical Center, Omaha

  3. 3

    Omaha, Nebraska

  4. 4

    Sioux Falls, South Dakota

  5. 5

    Omaha, Nebraska

  6. 6

    Kearney, Nebraska

  7. 7

    Lincoln, Nebraska

  8. 8

    Sioux Falls, South Dakota

  9. 9

    Lincoln, Nebraska

  10. 10

    Omaha, Nebraska

  11. 11

    Sioux City, Iowa

  12. 12

    Rockford, Illinois

  13. 13

    Rockford, Illinois

*Chief of Rheumatology, University of Nebraska Medical Center, Department of Internal Medicine, 600 South 42nd Street, Omaha, NE 68198-3025

Publication History

  1. Issue published online: 12 DEC 2005
  2. Article first published online: 12 DEC 2005
  3. Manuscript Accepted: 10 DEC 1996
  4. Manuscript Received: 20 SEP 1996

Funded by

  • Dodson Arthritis Grant
  • Albert G. and Bernice F. Hansen Charitable Foundation
  • University of Nebraska Hospital Research Support Fund

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Abstract

Objective. To determine if minocycline is an effective therapy for seropositive rheumatoid arthritis (RA) when used within the first year of disease.

Methods. The Rheumatoid Arthritis Investigational Network enrolled 46 patients with RA of <1 year duration into a 6-month study of minocycline (100 mg twice daily) versus placebo. All patients were rheumatoid factor positive. The primary end point of the study was successful completion of 6 months of treatment with no drug toxicity while maintaining 50% improvement in composite symptoms of arthritis.

Results. Eighteen of the 46 patients who were enrolled met 50% improvement criteria at 3 months, and maintained at least a 50% improvement for 6 months with no significant drug toxicity. Among them were 15 of the 23 patients (65%) treated with minocycline and 3 of 23 patients (13%) treated with placebo (P < 0.001).

Conclusion. In patients with early seropositive RA, therapy with minocycline is superior to placebo.

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