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Basic Science
Association of early osteoarthritis of the knee with a Taq I POLYMORPHISM OF THE VITAMIN D RECEPTOR GENE
Article first published online: 12 DEC 2005
DOI: 10.1002/art.1780400812
Copyright © 1997 American College of Rheumatology
1529-0131/asset/cover.gif?v=1&s=104d5c2bb8ef72deba26790b855af7ab80697a0e "Arthritis & Rheumatism")
Additional Information
How to Cite
Keen, R. W., Hart, D. J., Lanchbury, J. S. and Spector, T. D. (1997), Association of early osteoarthritis of the knee with a Taq I POLYMORPHISM OF THE VITAMIN D RECEPTOR GENE. Arthritis & Rheumatism, 40: 1444–1449. doi: 10.1002/art.1780400812
Publication History
- Issue published online: 12 DEC 2005
- Article first published online: 12 DEC 2005
- Manuscript Accepted: 17 MAR 1997
- Manuscript Received: 11 SEP 1996
Funded by
- Arthritis and Rheumatism Council (ARC)
- St. Thomas' Hospital Special Trustees
- Abstract
- References
- Cited By
Abstract
Objective. To determine whether a polymorphism of the vitamin D receptor (VDR) gene, already associated with osteoporosis, might also relate to the risk of osteoarthritis (OA).
Methods. A population cohort of 351 postmenopausal women (ages 45-64 years) was studied using anteroposterior radiographs of the knee, which were graded for OA according to the Kellgren and Lawrence classification system. The VDR genotype was determined by using polymerase chain reaction and by digestion with the restriction enzyme Taq I.
Results. The VDR allele “T” was associated with an increased risk of knee OA compared with the “t” allele, with an odds ratio of 2.82 (95% confidence interval 1.16-6.85; P = 0.02). A dominant pattern of risk was suggested. The frequency of the VDR genotype differed significantly between OA cases and controls (P = 0.03 by Fisher's exact test).
Conclusion. A Taq I polymorphism of the VDR gene appears to be associated with an increased risk of knee OA. This is the first genetic locus that has been shown to influence the risk of early knee OA within the general population.