The health locus of control and well-being of 53 lupus patients were compared to samples of healthy individuals and samples of those with other chronic diseases. The SLE sample had more negative affect, more positive affect, and a stronger belief in powerful others locus of control than healthy individuals. A subgroup of SLE patients who could predict their flares was identified. They had significantly more experience with the disease and a greater belief in internal health control. Disease duration and socioeconomic status explained significant amounts of variance in powerful-others locus of control. The learned helplessness model was tested and the results suggested that symptoms impact on well-being while disease duration and predictability of flares impact on health locus of control.