• 1
    Rashad S, Revell P, Hemingway A, Low F, Rainsford K, Walker F. Effect of non-steroidal anti-inflammatory drugs on the course of osteoarthritis. Lancet 1989; 213: 8491.
  • 2
    Pincus T, Koch GG, Sokka T, Lefkowith J, Wolfe F, Jordan JM, et al. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum 2001; 44: 158798.
  • 3
    Leardini G, Mattara L, Franceschini M, Perbellini A. Intra-articular treatment of knee osteoarthritis. Clin Exp Rheumatol 1991; 9: 37581.
  • 4
    Ravaud P, Moulinier L, Giraudeau B, Ayral X, Guerin C, Noel E, et al. Effects of joint lavage and steroid injection in patients with osteoarthritis of the knee: results of a multicenter, randomized, controlled trial. Arthritis Rheum 1999; 42: 47582.
  • 5
    Fisher NM, Gresham GE, Abrams M, Hicks J, Horrigan D, Pendergast DR. Quantitative effects of physical therapy on muscular and functional performance in subjects with osteoarthritis of the knee. Arch Phys Med Rehab 1993; 74: 8407.
  • 6
    American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000; 43: 190515.
  • 7
    Pendleton A, Arden N, Dougados M, Doherty M, Bannwarth B, Bijlsma JW, et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2000; 59: 93644.
  • 8
    Stefanich RJ. Intraarticular corticosteroids in treatment of osteoarthritis. Orthop Rev 1986; 15: 6571.
  • 9
    Creamer P. Intra-articular corticosteroid treatment in osteoarthritis. Curr Opin Rheumatol 1999; 11: 41721.
  • 10
    Yoshioka M, Shimizu C, Harwood FL, Coutts RD, Amiel D. The effects of hyaluronan during the development of osteoarthritis. Osteoarthritis Cartilage 1997; 5: 25160.
  • 11
    Yoshioka M, Shimizu C, Harwood FL, Coutts RD, Amiel DY. Long-term effects of hyaluronan on experimental osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 1998; 6: 19.
  • 12
    Hornsby PJ. DHEA: a biologist's perspective. J Am Geriatr Soc 1997; 45: 1395401.
  • 13
    Alexandersen P, Haarbo J, Christiansen C. The relationship of natural androgen to coronary heart disease in males: a review. Atherosclerosis 1996; 125: 114.
  • 14
    Zumoff B, Levin J, Rosenfeld RS, Markham M, Strain GW, Fukushima DK, et al. Abnormal 24-hour mean plasma concentrations of dehydroepiandrosterone and dehydroisoandrosterone sulfate in women with primary operable breast cancer. Cancer Res 1981; 41: 33603.
  • 15
    Coleman DL, Schwizer RW, Leiter EH. Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants in aged normal mice. Diabetes 1984; 33: 2632.
  • 16
    Barrett-Connor E, Ferrara A. Dehydroepiandrosterone, dehydroepiandrosterone sulfate, obesity, waist-hip ratio, and non-insulin dependent diabetes in postmenopausal women: the Rancho Bernardo Study. J Clin Endocrinol Metab 1996; 81: 5964.
  • 17
    Watson RR, Hulls A, Araghi-Niknam M, Chung S. Dehydroepiandrosterone (DHEA) supplementation to prevent symptoms of aging. Drugs Aging 1996; 9: 27491.
  • 18
    Mirone L, Altomonte L, D'Agostino P, Zoli A, Barini A, Magaro M. A study of serum androgen and cortisol levels in female patients with rheumatoid arthritis: correlation with disease activity. Clin Rheumatol 1996; 15: 1519.
  • 19
    Masi AT, Chrousos GP. Hypothalamic-pituitary-adrenal-glucocorticoid axis function in rheumatoid arthritis. J Rheumatol 1996; 23: 57781.
  • 20
    Dessein PH, Joffe BI, Stanwix AE, Moomal Z. Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis. Arthritis Res 2001; 3: 1838.
  • 21
    De la Torre B, Hedman M, Nilsson E, Olesen O, Thorner A. Relationship between blood and joint tissue DHEAS levels in rheumatoid arthritis and osteoarthritis. Clin Exp Rheumatol 1993; 11: 597601.
  • 22
    Cutolo M. Sex hormone adjuvant therapy in rheumatoid arthritis. Rheum Dis Clin North Am 2000; 26: 88195.
  • 23
    Williams PJ, Jones RH, Rademacher TW. Reduction in the incidence and severity of collagen-induced arthritis in DBA/1 mice, using exogenous dehydroepiandrosterone. Arthritis Rheum 1997; 40: 90711.
  • 24
    Jo H, Park JS, Kim EM, Jung MY, Lee SH, Seong SC, et al. The in vitro effects of dehydroepiandrosterone on human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2003; 11: 58594.
  • 25
    Jubb RW, Eggert FM. Staining of demineralized cartilage. II: quantitation of articular cartilage proteoglycan after fixation and rapid demineralization. Histochemistry 1981; 73: 3916.
  • 26
    Yoshioka M, Coutts RD, Amiel D, Hacker SA. Characterization of a model of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 1996; 4: 8798.
  • 27
    Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 1569.
  • 28
    De la Torre B, Hedman M, Nilsson E, Olesen O, Thorner A. Physiological importance of dehydroepiandrosterone. Lancet 1994; 343: 147981.
  • 29
    Araghi-Niknam M, Ardestani SK, Molitor M, Inserra P, Eskelson CD, Watson RR. Dehydroepiandrosterone (DHEA) sulfate prevents reduction in tissue vitamin E and increased lipid peroxidation due to murine retrovirus infection of aged mice. Proc Soc Exp Biol Med 1998; 218: 2107.
  • 30
    Pond MJ, Nuki G. Experimentally-induced osteoarthritis in the dog. Ann Rheum Dis 1973; 32: 3878.
  • 31
    Vignon E, Bejui J, Mathieu P, Hartmann JD, Ville G, Evieux JC, et al. Histological cartilage changes in a rabbit model of osteoarthritis. J Rheumatol Suppl 1987; 14: 1046.
  • 32
    Vignon E, Mathieu P, Bejui J, Descotes J, Hartmann D, Patricot LM, et al. Study of an inhibitor of plasminogen activator (tranexamic acid) in the treatment of experimental osteoarthritis. J Rheumatol Suppl 1991; 27: 1313.
  • 33
    Sommerlath KG, Gillquist J. The effects of an artificial meniscus substitute in a knee joint with a resected anterior cruciate ligament: an experimental study in rabbits. Clin Orthop 1993; 289: 27684.
  • 34
    Sommerlath KG, Gillquist J. The effect of anterior cruciate ligament resection and immediate or delayed implantation of a meniscus prosthesis on knee joint biomechanics and cartilage: an experimental study in rabbits. Clin Orthop 1993; 289: 26775.
  • 35
    Yoshimi T, Kikuchi T, Obara T, Yamaguchi T, Sakakibara Y, Itoh H, et al. Effects of high-molecular-weight sodium hyaluronate on experimental osteoarthrosis induced by the resection of rabbit anterior cruciate ligament. Clin Orthop 1994; 298: 296304.
  • 36
    Shimizu C, Yoshioka M, Coutts RD, Harwood FL, Kubo T, Hirasawa Y, et al. Long-term effects of hyaluronan on experimental osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 1998; 6: 19.
  • 37
    Bluteau G, Conrozier T, Mathieu P, Vignon E, Herbage D, Mallein-Gerin F. Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis. Biochim Biophys Acta 2001; 1526: 14758.
  • 38
    Hashimoto S, Creighton-Achermann L, Takahashi K, Amiel D, Coutts RD, Lotz M. Development and regulation of osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 2002; 10: 1807.