The genetic epidemiology of joint hypermobility: A population study of female twins
Version of Record online: 5 AUG 2004
Copyright © 2004 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 50, Issue 8, pages 2640–2644, August 2004
How to Cite
Hakim, A. J., Cherkas, L. F., Grahame, R., Spector, T. D. and MacGregor, A. J. (2004), The genetic epidemiology of joint hypermobility: A population study of female twins. Arthritis & Rheumatism, 50: 2640–2644. doi: 10.1002/art.20376
- Issue online: 5 AUG 2004
- Version of Record online: 5 AUG 2004
- Manuscript Accepted: 1 APR 2004
- Manuscript Received: 4 JAN 2004
- Welcome Trust
- Chronic Disease Research Foundation
- British Heart Foundation
- Arthritis Research Campaign
To estimate the genetic influence on joint hypermobility in an unselected population using a classic twin study design.
A self-report questionnaire on joint hypermobility as well as data on age, height, weight, estrogen replacement therapy, and menopause status were obtained from 483 monozygotic (MZ) and 472 dizygotic (DZ) unselected female twin pairs ages 21–81 years who were registered with the St Thomas' Adult Twin Registry in the UK.
The overall prevalence of hypermobility was 19.5% in MZ twins and 22.1% in DZ twins. The prevalence of hypermobile joints declined with age, falling from 34% in subjects ages 20–30 years to 18.4% in those ages 60 years or older. Significantly greater concordance for joint hypermobility was observed in the MZ twins when compared with the DZ twins (60% versus 36%), consistent with a genetic influence. In variance components analysis, the age- and body mass index–adjusted heritability of joint hypermobility was estimated to be 70% (95% confidence interval 57–89%).
Genetic factors have a substantial contribution to joint hypermobility in the adult female population.