Impact of fatigue on health-related quality of life in rheumatoid arthritis
Article first published online: 5 AUG 2004
Copyright © 2004 by the American College of Rheumatology
Arthritis Care & Research
Volume 51, Issue 4, pages 578–585, 15 August 2004
How to Cite
Rupp, I., Boshuizen, H. C., Jacobi, C. E., Dinant, H. J. and van den Bos, G. A. M. (2004), Impact of fatigue on health-related quality of life in rheumatoid arthritis. Arthritis & Rheumatism, 51: 578–585. doi: 10.1002/art.20539
- Issue published online: 5 AUG 2004
- Article first published online: 5 AUG 2004
- Manuscript Accepted: 12 NOV 2003
- Manuscript Received: 26 DEC 2002
- Rheumatoid arthritis;
- Depressive symptoms;
- RA-related pain;
- Health-related quality of life
To multidimensionally assess fatigue in rheumatoid arthritis (RA) and to evaluate the impact of fatigue on health-related quality of life (HRQOL).
The study was conducted in 1999 among 490 RA patients with varying disease duration. Fatigue was measured with the Multidimensional Fatigue Inventory (MFI-20) and HRQOL with a validated Dutch version of the RAND 36-Item Health Survey. We evaluated the impact of fatigue on HRQOL by multiple linear regression analyses taking into account RA-related pain and depressive symptoms.
Different aspects of fatigue selectively explained different dimensions of HRQOL. The MFI-20 was entered last to the linear regression models, resulting in an additional increase of explained variance of 1% (mental health) to 14% (vitality).
The multidimensional portrayal of RA-related fatigue can be used to develop intervention strategies targeted to specific aspects of fatigue. Fatigue, supplementary to RA-related pain and depressive symptoms, appears to be a feasible and treatable target in the clinical management of RA to increase HRQOL.