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Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis?: Results from the Nurses' Health Study
Article first published online: 4 NOV 2004
DOI: 10.1002/art.20621
Copyright © 2004 by the American College of Rheumatology
Additional Information
How to Cite
Karlson, E. W., Mandl, L. A., Hankinson, S. E. and Grodstein, F. (2004), Do breast-feeding and other reproductive factors influence future risk of rheumatoid arthritis?: Results from the Nurses' Health Study. Arthritis & Rheumatism, 50: 3458–3467. doi: 10.1002/art.20621
Publication History
- Issue published online: 4 NOV 2004
- Article first published online: 4 NOV 2004
- Manuscript Accepted: 10 AUG 2004
- Manuscript Received: 17 DEC 2003
Funded by
- NIH. Grant Numbers: K08-AR-02074-1, AR-47782, AR-36308, CA-87969
- Arthritis Foundation Investigator award
- American College of Rheumatology Clinician Investigator award
REFERENCES
- 1, , , . The epidemiology of rheumatoid arthritis in Rochester, Minnesota: a study of incidence, prevalence, and mortality. Am J Epidemiol 1980; 111: 87–98.
- 2, , , , . The incidence of rheumatoid arthritis in the United Kingdom: results from the Norfolk Arthritis Register. Br J Rheumatol 1994; 33: 735–9.
- 3, , . Hormonal and pregnancy relationships to rheumatoid arthritis: convergent effects with immunologic and microvascular systems. Semin Arthritis Rheum 1995; 25: 1–27.
- 4, . Sex hormones, HLA and rheumatoid arthritis. Clin Exp Rheumatol 1991; 9: 641–6.
- 5, , , . Prolonged hypogonadism in male patients with rheumatoid arthritis during flares in disease activity. Br J Rheumatol 1988; 27: 440–4.
- 6, , , , , , et al. Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition. J Rheumatol 1990; 17: 1620–2.
- 7
- 8, . Hormonal regulation of tumor necrosis factor-α, interleukin-12 and interleukin-10 production by activated macrophages: a disease-modifying mechanism in rheumatoid arthritis and systemic lupus erythematosus? Ann N Y Acad Sci 1999; 876: 14–31.Direct Link:
- 9, , . Timing of pregnancy in relation to the onset of rheumatoid arthritis. Arthritis Rheum 1992; 35: 152–5.Direct Link:
- 10, . Breast-feeding and the onset of rheumatoid arthritis. Arthritis Rheum 1994; 37: 808–13.Direct Link:
- 11, , , . Oral contraception, parity, breast feeding, and severity of rheumatoid arthritis. Ann Rheum Dis 1996; 55: 94–8.
- 12, . An investigation of gene-environment interaction in the etiology of rheumatoid arthritis. Am J Epidemiol 1994; 140: 453–60.
- 13, , . Breast feeding, other reproductive factors and rheumatoid arthritis: a prospective study. Br J Rheumatol 1995; 34: 542–6.
- 14, , , , . Estrogen and other female reproductive risk factors are not strongly associated with the development of rheumatoid arthritis in elderly women. Semin Arthritis Rheum 2003; 33: 72–82.
- 15, , , . The effect of oral contraceptives and estrogen replacement therapy on the risk of rheumatoid arthritis: a population based study. J Rheumatol 2004; 31: 207–13.
- 16, , . The pill, parity, and rheumatoid arthritis. Arthritis Rheum 1990; 33: 782–9.Direct Link:
- 17, , , . Oral contraceptives and rheumatoid arthritis: results from a primary care-based incident case-control study. Semin Arthritis Rheum 1997; 26: 817–23.
- 18, , , , . Reduction of the risk of rheumatoid arthritis among women who take oral contraceptives. Arthritis Rheum 1990; 33: 173–9.Direct Link:
- 19, , , , , , et al. Noncontraceptive hormones and rheumatoid arthritis in perimenopausal and postmenopausal women. JAMA 1986; 255: 1299–303.
- 20, , , . Do oral contraceptives reduce the incidence of rheumatoid arthritis? A pilot study using the Stockholm County medical information system. Scand J Rheumatol 1984; 13: 140–6.
- 21, , , , , , et al. Oral contraceptives and rheumatoid arthritis: further evidence for a preventive effect. Lancet 1982; 2: 839–42.
- 22, . Reduction in incidence of rheumatoid arthritis associated with oral contraceptives. Lancet 1978; 1: 569–71.
- 23, , . Rheumatoid arthritis, HLA identity, and age at menarche. Ann Rheum Dis 1993; 52: 322–6.
- 24, , , , , , et al. Exogenous sex hormones and the risk of rheumatoid arthritis. Arthritis Rheum 1990; 33: 947–53.Direct Link:
- 25, , . Oral contraceptives and rheumatoid arthritis: new data from the Royal College of General Practitioners' oral contraception study. Ann Rheum Dis 1990; 49: 744–6.
- 26, , , , . Do oral contraceptives prevent rheumatoid arthritis? JAMA 1985; 254: 1938–41.
- 27, , , . Case-control study of rheumatoid arthritis and prior use of oral contraceptives. Lancet 1983; 1: 1299–300.
- 28
- 29, , , , . Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum 2002; 46: 625–31.Direct Link:
- 30, , , , . Does estrogen replacement therapy protect against rheumatoid arthritis? J Rheumatol 1991; 18: 1473–6.
- 31, , . Postmenopausal hormones and the incidence of rheumatoid arthritis. J Rheumatol 1989; 16: 911–3.
- 32, , , , . Non-contraceptive hormones and the risk of rheumatoid arthritis in menopausal women. Int J Epidemiol 1994; 23: 1248–55.
- 33, , . The Nurses' Health Study: 20-year contribution to the understanding of health among women. J Womens Health 1997; 6: 49–62.
- 34
- 35, , , , , , et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315–24.Direct Link:
- 36, , , , , , et al. Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 2002; 46: 83–91.Direct Link:
- 37SAS/STAT user's guide: version 6, 4th ed. Cary, NC: SAS Institute; 1990.
- 38
- 39, , , , . Pregnancy and the risk of developing rheumatoid arthritis. Arthritis Rheum 1990; 33: 1770–5.Direct Link:
- 40, , . Oral contraceptives and the risk of rheumatoid arthritis: a meta-analysis of a conflicting literature. Br J Rheumatol 1989; 28 Suppl 1: 13–7; discussion 18–23.
- 41, . Oral contraceptives and rheumatoid arthritis [letter]. Lancet 1983; 1: 1437.
- 42, , , . The relationship between rheumatoid arthritis and reproductive function. Br J Rheumatol 1989; 28 Suppl 1: 33; discussion 42–5.
- 43. Parity status and the development of rheumatoid arthritis. Am J Reprod Immunol 1992; 28: 228–30.
- 44. Rheumatoid arthritis in US adults 1960-62. In: BennettPH, WoodHN, editors. Population studies of the rheumatic diseases. Amsterdam: Exerpta Medica; 1968. p. 83–92.
- 45, , , , , . Rheumatoid arthritis in women: incidence rates in Group Health Cooperative, Seattle, Washington, 1987–1989. Arthritis Rheum 1991; 34: 1502–7.Direct Link:
- 46. Incidence of rheumatoid arthritis: do the observed age-sex interaction patterns support a role of androgenic-anabolic steroid deficiency in its pathogenesis? Br J Rheumatol 1994; 33: 697–9.
- 47
- 48, , , , . Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum 1991; 34: 1–5.Direct Link:
- 49, , , . The influence of pituitary hormones on adjuvant arthritis. Arthritis Rheum 1984; 27: 682–8.Direct Link:
- 50, , . The possible role of prolactin in autoimmunity. Am J Reprod Immunol 1991; 26: 118–23.
- 51. Prolactin: a hormone with immunoregulatory properties that leads to new therapeutic approaches in rheumatic diseases. J Rheumatol 1992; 19: 839–41.
- 52, , , , . Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations. J Immunol 1993; 150: 5673–81.
- 53, , , , . Prolactin locally produced by synovium infiltrating T lymphocytes induces excessive synovial cell functions in patients with rheumatoid arthritis. J Rheumatol 1999; 26: 1890–900.
- 54, , , , . Up-modulation of interferon-γ mediates the enhancement of spontaneous cytotoxicity in prolactin-activated natural killer cells. Immunology 1999; 98: 386–92.Direct Link:
- 55, . Cooperation of pituitary hormone prolactin with interleukin-2 and interleukin-12 on production of interferon-γ by natural killer and T cells. Ann N Y Acad Sci 2000; 917: 505–13.Direct Link:
- 56, , , , , , et al. Hyperprolactinemia inhibits natural killer (NK) cell function in vivo and its bromocriptine treatment not only corrects it but makes it more efficient. J Clin Immunol 1992; 12: 210–5.
- 57, , , , , . T-cell dysregulation in patients with hyperprolactinemia: effect of bromocriptine treatment. Clin Immunol Immunopathol 1986; 38: 337–43.
- 58. Prolactin enhances production of interferon-γ, interleukin-12, and interleukin-10, but not of tumor necrosis factor-α, in a stimulus-specific manner. Cytokine 2003; 21: 187–94.
- 59, , , , . Defective hypothalamic response to immune and inflammatory stimuli in patients with rheumatoid arthritis. Arthritis Rheum 1992; 35: 1281–8.
- 60. Do sex hormones modulate the synovial macrophages in rheumatoid arthritis? Ann Rheum Dis 1997; 56: 281–4.
- 61, , , , . Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis. Arthritis Rheum 2002; 46: 654–62.Direct Link:
- 62, , , . Cumulative duration of breast-feeding influences cortisol levels in postmenopausal women. J Womens Health Gend Based Med 2001; 10: 681–7.
- 63, , , , , , et al. IL-12, TNF-α, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab 2001; 86: 4933–8.
- 64, , . Mechanism of immunosuppression of progesterone on maternal lymphocyte activation during pregnancy. J Immunol 1979; 122: 1978–85.
- 65, , , , . Treatment with progesterone analogues decreases macrophage Fcγ receptors expression. Clin Immunol Immunopathol 1998; 89: 231–9.
- 66, , , , , . Progesterone as an immunomodulatory molecule. Int Immunopharmacol 2001; 1: 1037–48.
- 67, , , , , . Suppression of interleukin 8 production by progesterone in rabbit uterine cervix. Biochem J 1994; 301(Pt 1): 183–6.
- 68, , , , . Are both genetic and reproductive associations with rheumatoid arthritis linked to prolactin? Lancet 1996; 348: 106–9.

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