• 1
    Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998; 41: 77899.
  • 2
    Odding E, Valkenburg HA, Algra D, Vandenouweland FA, Grobbee DE, Hofman A. Associations of radiological osteoarthritis of the hip and knee with locomotor disability in the Rotterdam Study. Ann Rheum Dis 1998; 57: 2038.
  • 3
    MacGregor AJ, Antoniades L, Matson M, Andrew T, Spector TD. The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 2000; 43: 24106.
  • 4
    Felson DT, Couropmitree NN, Chaisson CE, Hannan MT, Zhang Y, McAlindon TE, et al. Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: the Framingham Study. Arthritis Rheum 1998; 41: 106471.
  • 5
    Mendler M, Eich-Bender SG, Vaughan L, Winterhalter KH, Bruckner P. Cartilage contains mixed fibrils of collagen types II, IX, and XI. J Cell Biol 1989; 108: 1917.
  • 6
    Diab M, Wu JJ, Eyre DR. Collagen type IX from human cartilage: a structural profile of intermolecular cross-linking sites. Biochem J 1996; 314: 32732.
  • 7
    Hagg R, Hedbom E, Mollers U, Aszodi A, Fassler R, Bruckner P. Absence of the α1(IX) chain leads to a functional knock-out of the entire collagen IX protein in mice. J Biol Chem 1997; 272: 206504.
  • 8
    Fassler R, Schnegelsberg PN, Dausman J, Shinya T, Muragaki Y, McCarthy MT, et al. Mice lacking α1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A 1994; 91: 50704.
  • 9
    Loughlin J, Mustafa Z, Dowling B, Southam L, Marcelline L, Raina SS, et al. Finer linkage mapping of a primary hip osteoarthritis susceptibility locus on chromosome 6. Eur J Hum Genet 2002; 10: 5628.
  • 10
    Mustafa Z, Chapman K, Irven C, Carr AJ, Clipsham K, Chitnavis J, et al. Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritis. Rheumatology (Oxford) 2000; 39: 299306.
  • 11
    Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA. Determinants of disease and disability in the elderly: the Rotterdam Elderly Study. Eur J Epidemiol 1991; 7: 40322.
  • 12
    KellgrenJH, LawrenceJS, editors. The epidemiology of chronic rheumatism, atlas of standard radiographs. Oxford: Blackwell Scientific; 1963.
  • 13
    Warman ML, Tiller GE, Polumbo PA, Seldin MF, Rochelle JM, Knoll JH, et al. Physical and linkage mapping of the human and murine genes for the α1 chain of type IX collagen (COL9A1). Genomics 1993; 17: 6948.
  • 14
    Guo X, Elston RC. Two-stage global search designs for linkage analysis I: use of the mean statistic for affected sib pairs. Genet Epidemiol 2000; 18: 97110.
  • 15
    Yoshioka H, Zhang H, Ramirez F, Mattei MG, Moradi-Ameli M, van der Rest M, et al. Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and α1 (IX) collagen (COL9A1) on 6q12-q14 in humans. Genomics 1992; 13: 8846.