Dr. Putterman has received consulting fees of less than $10,000 from Biogen Idec. Ms Bixler and Drs. Ambrose and Kalled own stock in Biogen Idec.
BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus
Version of Record online: 28 JUN 2005
Copyright © 2005 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 52, Issue 7, pages 2080–2091, July 2005
How to Cite
Stohl, W., Xu, D., Kim, K. S., Koss, M. N., Jorgensen, T. N., Deocharan, B., Metzger, T. E., Bixler, S. A., Hong, Y. S., Ambrose, C. M., Mackay, F., Morel, L., Putterman, C., Kotzin, B. L. and Kalled, S. L. (2005), BAFF overexpression and accelerated glomerular disease in mice with an incomplete genetic predisposition to systemic lupus erythematosus. Arthritis & Rheumatism, 52: 2080–2091. doi: 10.1002/art.21138
- Issue online: 28 JUN 2005
- Version of Record online: 28 JUN 2005
- Manuscript Accepted: 4 APR 2005
- Manuscript Received: 13 DEC 2004
- NIH. Grant Numbers: AI-45050, AR-486912, AI-51392, AR-37070
- Target Identification in Lupus award from the Alliance for Lupus Research/Arthritis Foundation
- Hulda Irene Duggan Arthritis Investigator award from the Arthritis Foundation
To determine whether overexpression of BAFF can accelerate the development of systemic lupus erythematosus–associated end-organ disease in hosts with an underlying autoimmune diathesis.
We introduced a BAFF transgene (Tg) into autoimmune-prone B6.Sle1 and B6.Nba2 mice and evaluated these mice for serologic autoimmunity and renal pathology.
B6.Sle1.BAFF and B6.Nba2.BAFF mice, but not non-Tg littermates, frequently developed severe glomerular pathology by 3 months of age. Age-matched B6.BAFF mice, despite renal Ig deposits and increases in B cells and Ig production similar to those in B6.Sle1.BAFF and B6.Nba2.BAFF mice, did not develop glomerular pathology. In B6.Sle1.BAFF and B6.Nba2.BAFF mice, severity of glomerular disease did not obligately correlate with circulating levels of IgG antichromatin and/or anti–double-stranded DNA antibodies or with amounts of these autoantibodies deposited in the kidneys. Even in mice with severe glomerular disease, renal tubulointerstitial infiltrates were very limited, and increased proteinuria was not detected.
BAFF-driven effects on glomerular pathology may be mediated, at least in part, by autoantibodies with specificities other than chromatin and/or by autoantibody-independent means. There is an uncoupling of BAFF-driven precocious glomerular pathology from concomitant development of clinically apparent renal disease, strongly suggesting that BAFF overexpression works in concert with other factors to promote overt renal disease.