Drs. Morgan and Flierman contributed equally to this work.
Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells
Article first published online: 28 JUN 2005
Copyright © 2005 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 52, Issue 7, pages 2212–2221, July 2005
How to Cite
Morgan, M. E., Flierman, R., van Duivenvoorde, L. M., Witteveen, H. J., van Ewijk, W., van Laar, J. M., de vries, R. R. P. and Toes, R. E. M. (2005), Effective treatment of collagen-induced arthritis by adoptive transfer of CD25+ regulatory T cells. Arthritis & Rheumatism, 52: 2212–2221. doi: 10.1002/art.21195
- Issue published online: 28 JUN 2005
- Article first published online: 28 JUN 2005
- Manuscript Accepted: 19 APR 2005
- Manuscript Received: 21 OCT 2004
- The Netherlands Organization for Scientific Research. Grant Number: 901-09-262
- Gisela Thier Funds
- Dutch Arthritis Foundation. Grant Numbers: 02-1-402, 01-2-401
- The Netherlands Organization for Scientific Research
Regulatory T cells play an important role in the prevention of autoimmunity and have been shown to be effective in the treatment of experimental colitis, a T cell–mediated and organ-specific disease. We previously demonstrated that intrinsic CD25+ regulatory T cells modulate the severity of collagen-induced arthritis (CIA), which, in contrast to colitis, is a systemic antibody-mediated disease and an accepted model of rheumatoid arthritis. We undertook this study to determine whether regulatory T cells have the potential to be used therapeutically in arthritis.
We transferred CD4+,CD25+ T cells into mice exhibiting arthritis symptoms, both immunocompetent mice and mice subjected to lethal irradiation and rescued with syngeneic bone marrow transplantation.
A single transfer of regulatory T cells markedly slowed disease progression, which could not be attributed to losses of systemic type II collagen–specific T and B cell responses, since these remained unchanged after adoptive transfer. However, regulatory T cells could be found in the inflamed synovium soon after transfer, indicating that regulation may occur locally in the joint.
Our data indicate that CD25+ regulatory T cells can be used for the treatment of systemic, antibody-mediated autoimmune diseases, such as CIA.