High-resolution magnetic resonance imaging for the assessment of hand osteoarthritis
Version of Record online: 28 JUL 2005
Copyright © 2005 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 52, Issue 8, pages 2355–2365, August 2005
How to Cite
Tan, A. L., Grainger, A. J., Tanner, S. F., Shelley, D. M., Pease, C., Emery, P. and McGonagle, D. (2005), High-resolution magnetic resonance imaging for the assessment of hand osteoarthritis. Arthritis & Rheumatism, 52: 2355–2365. doi: 10.1002/art.21210
- Issue online: 28 JUL 2005
- Version of Record online: 28 JUL 2005
- Manuscript Accepted: 3 MAY 2005
- Manuscript Received: 7 FEB 2005
- Medical Research Council, UK
- Arthritis Research Campaign, UK
To investigate the use of a novel surface coil for clinically utilized magnetic resonance imaging (MRI) scanners, in order to describe the microanatomic basis for hand osteoarthritis (OA) at all stages of disease.
MRI of proximal or distal interphalangeal joints was performed in 58 subjects: 16 patients with early OA (symptom duration ≤12 months), 14 patients with chronic OA, 10 patients with clinically normal asymptomatic joints adjacent to arthritic joints, and 18 normal controls. High-resolution images were obtained with displayed pixel dimensions of 80–100 μm using a 1.5T scanner and a 23-mm–diameter surface coil. All joint structures were evaluated.
The high-resolution images of every joint structure showed comparable abnormalities in both early and chronic OA, including cartilage loss, bone edema, synovial enhancement, osteophytosis, and erosions. Heberden's and Bouchard's node formation occurred at regions where soft tissue bulged through the capsule between the dorsal tendons and collateral ligaments (CLs). Prominent CL thickening or disruption (100% of OA patients) was evident even in joints where cartilage was partially preserved. Clinically normal joints adjacent to OA hand joints showed thickening and enhancement of CLs which was the most common abnormality seen (80% of OA patients). Older normal subjects showed subtle changes within the CLs.
Obtaining high-resolution MR images from clinically utilized scanners represents a novel way for exploring the microanatomic basis of hand arthritis and may have considerable potential in the clinical setting. In the present evaluation in nodal OA, previously unappreciated CL abnormalities were especially common.