• 1
    Murphy G, Knauper V, Atkinson S, Butler G, English W, Hutton M, et al. Matrix metalloproteinases in arthritic disease. Arthritis Res 2002; Suppl 3: S3949.
  • 2
    Kaushal GP, Shah SV. The new kids on the block: ADAMTSs, potentially multifunctional proteinases of the ADAM family. J Clin Invest 2000; 105: 13357.
  • 3
    Page Thomas DP, King B, Stephens T, Dingle JT. In vivo studies of cartilage regeneration after damage induced by cabolin/interleukin-1. Ann Rheum Dis 1991; 50: 7580.
  • 4
    Fell HB, Jubb RW. The breakdown of collagen by chondrocytes. J Pathol 1980; 130: 15967.
  • 5
    Bigg HF, Rowan AD. The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis. Curr Opin Pharmacol 2001; 1: 31420.
  • 6
    Milner JM, Elliott SF, Cawston TE. Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways. Arthritis Rheum 2000; 44: 208496.
  • 7
    Cawston TE, Curry VA, Summers CA, Clark IM, Riley GP, Life PF, et al. The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint. Arthritis Rheum 1998; 41: 176071.
  • 8
    Westacott CI, Whicher JT, Barnes IC, Thompson D, Swan AJ, Dieppe PA. Synovial fluid concentration of five different cytokines in rheumatic diseases. Ann Rheum Dis 1990; 49: 67681.
  • 9
    Hui W, Cawston TE, Richards CD, Rowan AD. A model for inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL. Arthritis Res Ther 2005; 7: R5764.
  • 10
    Rowan AD, Hui W, Cawston TE, Richards CD. Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model. Am J Pathol 2003; 162: 197584.
  • 11
    Koshy PJ, Lundy CJ, Rowan AD, Porter S, Edwards DR, Hogan A, et al. The modulation of matrix metalloproteinases and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription–polymerase chain reaction. Arthritis Rheum 2002; 46: 9617.
  • 12
    Van den Berg WB, van Riel PL. Uncoupling of inflammation and destruction in rheumatoid arthritis: myth or reality? [editorial]. Arthritis Rheum 2005; 52: 9959.
  • 13
    Caterson B, Flannery CR, Hughes CE, Little CB. Mechanisms involved in cartilage proteoglycan catabolism. Matrix Biol 2000; 4: 3344.
  • 14
    Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, et al. Aggrecan protects cartilage collagen from proteolytic cleavage. J Biol Chem 2003; 278: 4553945.
  • 15
    Shingleton WD, Ellis AJ, Rowan AD, Cawston TE. Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown. J Cell Biochem 2000; 79: 51931.
  • 16
    Shah RL, Chen AC, Grodzinsky AJ, Trippel SB. Differential effects of bFGF and IGF-1 on matrix metabolism in calf and adult bovine cartilage experiments. Arch Biochem Biophys 1994; 308: 13747.
  • 17
    Tyler JA. Insulin-like growth factor 1 can decrease degradation and promote synthesis of proteoglycan in cartilage exposed to cytokines. Biochem J 1989; 260: 5438.
  • 18
    Hui W, Rowan AD, Cawston TE. Insulin-like growth factor-1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with interleukin-1α. Ann Rheum Dis 2001; 60: 25461.
  • 19
    Hascall VC, Handley CJ, McQuillan DJ, Hascall GK, Robinson HC, Lowther DA. The effect of serum on biosynthesis of proteoglycans by bovine articular cartilage in culture. Arch Biochem Biophys 1983; 224: 20623.
  • 20
    De Ceuninck F, Dassencourt L, Anract P. The inflammatory side of human chondrocytes unveiled by antibody microarrays. Biochem Biophys Res Commun 2004; 323: 96090.
  • 21
    Hui W, Rowan AD, Richards CD, Cawston TE. Oncostatin M in combination with tumor necrosis factor α induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo. Arthritis Rheum 2003; 48: 340418.
  • 22
    Yu EW, Dolter KE, Shao LE, Yu J. Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies. Clin Exp Immunol 1998; 112: 12632.
  • 23
    Fonsea-Aten M, Rios AM, Mejias A, Charvez-Bueno S, Katz K, Gomez AM, et al. Mycoplasma pneumoniae induces host dependent pulmonary inflammation and airway obstruction in mice. Am J Respir Cell Mol Biol 2004; 32: 20110.
  • 24
    Lui M, Sun H, Wang X, Koike T, Mishima H, Ikeda K, et al. Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis. Arthritis Rheum 2004; 50: 31127.
  • 25
    Matsumoto S, Kobayashi T, Katoh M, Saito S, Ikeda Y, Kobori M, et al. Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development. Am J Pathol 1998; 53: 10919.
  • 26
    D'Alessio S, Fibbi G, Cinelli M, Guiducci S, del Rosso A, Margheri F, et al. Matrix metalloproteinase 12–dependent cleavage of the urokinase receptor in systemic sclerosis microvascular endothelial cells results in impaired angiogenesis. Arthritis Rheum 2004; 50: 327585.
  • 27
    Bradley K, North J, Schwaeska W, Jeziorska M, Woolley DE, Whaley K. Synthesis of classical pathway components by chondrocytes. Immunology 1996; 88: 64856.
  • 28
    Nakagawa K, Sakiyama H, Tsuchida T, Yamaguchi K, Toyoguchi T, Masuda R, et al. Complement C1s activation in degenerating articular cartilage of rheumatoid arthritis patients: immunohistochemical studies with an active form specific antibody. Ann Rheum Dis 1999; 58: 17581.
  • 29
    O'Hara R, Murphy EP, Whitehead AS, Fitzgerald O, Bresnihan B. Acute-phase serum amyloid A production by rheumatoid arthritis synovial tissue. Arthritis Res 2000; 2: 1424.
  • 30
    Heinrich PC, Behrmann I, Haan S, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signaling and its regulation. Biochem J 2003; 374: 120.
  • 31
    Guerne PA, Zuraw BL, Vaughan JH, Carson DA, Lotz M. Synovium as a source of interleukin 6 in vitro: contribution to local and systemic manifestations of arthritis. J Clin Invest 1989; 83: 58592.
  • 32
    Koch AE, Volin MV, Woods JM, Kunkel SL, Connors MA, Harlow LA, et al. Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid joint. Arthritis Rheum 2001; 44: 3140.
  • 33
    Merz D, Lui R, Johnson K, Terkeltaub R. IL-8/CXCL8 and growth-related oncogene α/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol 2003; 171: 440615.
  • 34
    Ognjanvovic S, Bryant-Greenwood GP. Pre-B-colony-enhancing factor, a novel cytokine of human fetal membrane. Am J Obstet Gynecol 2002; 187: 10518.
  • 35
    Youssef P, Roth J, Frosch M, Costello P, Fitzgerald O, Sorg C, et al. Expression of myeloid related proteins (MRP) 8 and 14 and the MRP 8/14 heterodimer in rheumatoid arthritis synovial membrane. J Rheumatol 1999; 26: 25238.
  • 36
    Frosch M, Stey A, Vogl T, Wulffraat NM, Kuis W, Sunderkotter C, et al. Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum 2000; 43: 62837.
  • 37
    Luchetti MM, Piccinini G, Mantovani A, Peri G, Matteucci C, Pomponi G, et al. Expression and production of long pentraxin PTX-3 in rheumatoid arthritis (RA). Clin Exp Immunol 2000; 119: 196202.
  • 38
    Bottazzi B, Vouret-Craviari V, Bastoni A, de Gioia L, Matteucci C, Peri G, et al. Multimer formation and ligand recognition by the long pentraxin PTX-3: similarities and differences with the short pentraxin C-reactive protein and serum amyloid P component. J Biol Chem 1997: 272: 3281723.
  • 39
    Rusnati M, Camozzi M, Moroni E, Bottazzi B, Peri G, Indraccolo S, et al. Selective recognition of fibroblast growth factor 2 by the long pentraxin PTX-3 inhibits angiogenesis. Blood 2004; 104: 929.
  • 40
    Sehnert B, Cavcic A, Bohm B, Kalden JR, Nandakumar KS, Holmdahl R, et al. Antileukoproteinase: modulation of neutrophil function and therapeutic effects on anti–type II collagen antibody–induced arthritis. Arthritis Rheum 2004; 50: 234759.
  • 41
    Ota F, Maeshima A, Yamashita S, Ikeuchi H, Kaneko Y, Kuroiwa T, et al. Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum 2003; 48: 24429.
  • 42
    Hermansson M, Sawaji Y, Bolton M, Alexander S, Wallace A, Begum S, et al. Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin β A (activin A), a regulatory molecule for chondrocytes. J Biol Chem 2004; 279: 4351421.
  • 43
    Luyten FP, Chen P, Paralkar V, Reddi AH. Recombinant bone-morphogenic protein-4, transforming growth factor β1, and activin A enhance the cartilage phenotype of articular cartilage in vitro. Exp Cell Res 1994; 210: 2249.
  • 44
    Hui W, Rowan AD, Cawston T. Transforming growth factor β1 blocks the release of collagen fragments from bovine nasal cartilage stimulated by oncostatin M in combination with IL-1α. Cytokine 2000; 12: 7659.
  • 45
    Hakala B, White C, Recklies AD. Human cartilage gp-39, a secretory product of articular chondrocytes and synovial cells is a mammalian member of a chitinase protein family. J Biol Chem 1993; 268: 2580310.
  • 46
    Kirkpatrick RB, Emery JG, Connor JR, Dodds R, Lysko PG, Rosenberg M. Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages. Exp Cell Res 1997; 237: 4654.
  • 47
    Recklies AD, White C, Ling H. The chitinase 3-like protein human cartilage glycoprotein 39 (HC-39) stimulates proliferation of human connective tissue and activates both extracellular signal-regulated kinase and protein kinase B-mediated signaling pathways. Biochem J 2002; 365: 11926.
  • 48
    Ling H, Recklies AD. The chitinase 3 like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor α. Biochem J 2004; 380: 6519.
  • 49
    Hu B, Trinh K, Figueira WF, Price P. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. J Biol Chem 1996; 271: 1941529.
  • 50
    Ross AD, Banda NK, Muggli M, Arend WP. Enhancement of collagen-induced arthritis in mice genetically deficient in extracellular superoxide dismutase. Arthritis Rheum 2004; 50: 370211.