Effects of supervised cardiovascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus
Version of Record online: 7 DEC 2005
Copyright © 2005 by the American College of Rheumatology
Arthritis Care & Research
Volume 53, Issue 6, pages 838–844, 15 December 2005
How to Cite
Carvalho, M. R. P. d., Sato, E. I., Tebexreni, A. S., Heidecher, R. T. C., Schenkman, S. and Neto, T. L. B. (2005), Effects of supervised cardiovascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus. Arthritis & Rheumatism, 53: 838–844. doi: 10.1002/art.21605
- Issue online: 7 DEC 2005
- Version of Record online: 7 DEC 2005
- Manuscript Accepted: 18 APR 2005
- Manuscript Received: 7 OCT 2004
- Fundação de Amparo a Pesquisa do Estado de São Paulo. Grant Number: 00/02351-5
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil
- Systemic lupus erythematosus;
- Cardiovascular training;
- Exercise tolerance;
- Quality of life
To determine if supervised cardiovascular training improves exercise tolerance, aerobic capacity, depression, functional capacity, and quality of life in patients with systemic lupus erythematosus (SLE).
Sixty women with SLE (ages 18–55 years) were evaluated using Short Form 36, visual analog scale for pain, scale for fatigue, Beck Depression Inventory, and Health Assessment Questionnaire (HAQ), and participated in a training protocol of incremental load on a treadmill with computed gas metabolic analysis. Maximum oxygen consumption (VO2max) and anaerobic threshold VO2 were calculated with a SensorMedics Vmax29C analyzer (Sensor Medics, Yorba Linda, CA), and heart rate was measured by electrocardiogram. Patients were divided into 2 groups: a training group (41 patients) that participated in the supervised cardiovascular training program and a control group (19 patients) that did not participate in the program. All variables were analyzed at baseline and after 12 weeks for both groups. The training program occurred in the morning for 60 minutes, 3 times a week for 12 weeks. Statistical analysis included Wilcoxon's rank sum test, Mann-Whitney U test, chi-square test, and Fisher's exact test. P values <0.05 were considered to be statistically significant.
The 2 groups were homogeneous and comparable at baseline. The training group showed a significant improvement of aerobic capacity measured by anaerobic threshold VO2 (14.67 ± 3.03 versus 17.08 ± 3.35 ml/kg/minute, P < 0.001). Comparison of the training group and control group after 12 weeks showed a significant difference relating to VO2max (24.31 ± 4.61 versus 21.21 ± 3.88 ml/kg/minute, P = 0.01) and anaerobic threshold VO2 (17.08 ± 3.35 versus 13.66 ± 2.82 ml/kg/minute, P < 0.0001). After cardiovascular training, we found a significant improvement of Beck inventory score (8.37 ± 12.79 versus 2.90 ± 3.00, P < 0.001) and HAQ score (0.14 ± 0.21 versus 0.06 ± 0.19, P < 0.01) in the training group.
This study showed significant improvement in exercise tolerance, aerobic capacity, quality of life, and depression after a supervised cardiovascular training program in patients with SLE.