Research Article

You have full text access to this OnlineOpen article

Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response

  1. Xin You1,†,‖,
  2. Meng Pan1,‡,‖,
  3. Wenli Gao1,
  4. Her-Shyong Shiah1,
  5. Jian Tao1,
  6. Dongqing Zhang1,§,
  7. Fotios Koumpouras1,
  8. Shuang Wang1,¶,
  9. Hongyu Zhao1,
  10. Joseph A. Madri1,
  11. David Baker2,
  12. Yung-Chi Cheng1,
  13. Zhinan Yin1,*

Article first published online: 28 FEB 2006

DOI: 10.1002/art.21640

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 54, Issue 3, pages 877–886, March 2006

Additional Information

How to Cite

You, X., Pan, M., Gao, W., Shiah, H.-S., Tao, J., Zhang, D., Koumpouras, F., Wang, S., Zhao, H., Madri, J. A., Baker, D., Cheng, Y.-C. and Yin, Z. (2006), Effects of a novel tylophorine analog on collagen-induced arthritis through inhibition of the innate immune response. Arthritis & Rheumatism, 54: 877–886. doi: 10.1002/art.21640

Author Information

  1. 1

    Yale University, New Haven, Connecticut

  2. 2

    University of Tennessee, Knoxville

  1. †

    University of California, San Diego

  2. ‡

    Ruijing Hospital, Shanghai Second Medical University, Shanghai, China

  3. §

    Shanghai Jiao Torg University, Shanghai, China

  4. Columbia University, New York, New York

  1. ‖

    Drs. You and Pan contributed equally to this work.

*Section of Rheumatology, Yale University School of Medicine, Box 208031, The Anylan Center (TAC), Room 517, 300 Cedar Street, New Haven, CT 06520-8031

Publication History

  1. Issue published online: 28 FEB 2006
  2. Article first published online: 28 FEB 2006
  3. Manuscript Accepted: 10 NOV 2005
  4. Manuscript Received: 3 AUG 2005

Funded by

  • Arthritis Foundation Investigator award
  • NIH. Grant Numbers: K01-AR-02188, 1-R01-AI-056219

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (230K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Ziwen Wang, Meng Wu, Yi Wang, Zheng Li, Lei Wang, Guifang Han, Fazhong Chen, Yuxiu Liu, Kailiang Wang, Ao Zhang, Linghua Meng, Qingmin Wang, Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents, European Journal of Medicinal Chemistry, 2012, 51, 250

    CrossRef

  2. 2
    Takashi Ikeda, Takashi Yaegashi, Takeshi Matsuzaki, Syusuke Hashimoto, Seigo Sawada, Asymmetric synthesis of phenanthroindolizidine alkaloids with hydroxyl group at the C14 position and evaluation of their antitumor activities, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 1, 342

    CrossRef

  3. 3
    Jian Tao, Masahito Kamanaka, Jianlei Hao, Zhifang Hao, Xi Jiang, Joe E Craft, Richard A Flavell, Zhenzhou Wu, Zhangyong Hong, Liqing Zhao, Zhinan Yin, IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis, Arthritis Research & Therapy, 2011, 13, 6, R212

    CrossRef

  4. 4
    Zhenjia Liu, Haining Lv, Hongyan Li, Yi Zhang, Haijing Zhang, Fuqin Su, Song Xu, Yong Li, Yikang Si, Shishan Yu, Xiaoguang Chen, Interaction Studies of an Anticancer Alkaloid, (+)-(13aS)-Deoxytylophorinine, with Calf Thymus DNA and Four Repeated Double-Helical DNAs, Chemotherapy, 2011, 57, 4, 310

    CrossRef

  5. 5
    Takashi Ikeda, Takashi Yaegashi, Takeshi Matsuzaki, Ryuta Yamazaki, Syusuke Hashimoto, Seigo Sawada, Synthesis of phenanthroindolizidine alkaloids and evaluation of their antitumor activities and toxicities, Bioorganic & Medicinal Chemistry Letters, 2011, 21, 19, 5978

    CrossRef

  6. 6
    Hye-Young Min, Su-Hyun Song, Boeun Lee, Sanghee Kim, Sang Kook Lee, Inhibition of Lipopolysaccharide-Induced Nitric Oxide Production by Antofine and Its Analogues in RAW 264.7 Macrophage Cells, Chemistry & Biodiversity, 2010, 7, 2
    Direct Link:
  7. 7
    Shailesh R. Satpute, Malarvizhi Durai, Kamal D. Moudgil, Antigen-Specific Tolerogenic and Immunomodulatory Strategies for the Treatment of Autoimmune Arthritis, Seminars in Arthritis and Rheumatism, 2008, 38, 3, 195

    CrossRef

  8. 8
    Wenli Gao, Annie Pei-Chun Chen, Chung-Hang Leung, Elizabeth A. Gullen, Alois Fürstner, Qian Shi, Linyi Wei, Kuo-Hsiung Lee, Yung-Chi Cheng, Structural analogs of tylophora alkaloids may not be functional analogs, Bioorganic & Medicinal Chemistry Letters, 2008, 18, 2, 704

    CrossRef

  9. 9
    Fang Zheng, Luo Xu, Lieve Verbiest, Eric Verbeken, Dirk De Ridder, Jan Deprest, Cytokine production following experimental implantation of xenogenic dermal collagen and polypropylene grafts in mice, Neurourology and Urodynamics, 2007, 26, 2
    Direct Link:
  10. 10
    Wenli Gao, Scott Bussom, Susan P. Grill, Elizabeth A. Gullen, You-Cai Hu, Xueshi Huang, Sanbao Zhong, Conrad Kaczmarek, Julio Gutierrez, Samson Francis, David C. Baker, Shishan Yu, Yung-Chi Cheng, Structure–activity studies of phenanthroindolizidine alkaloids as potential antitumor agents, Bioorganic & Medicinal Chemistry Letters, 2007, 17, 15, 4338

    CrossRef

  11. 11
    Jin-Young Choi, Wenli Gao, Jared Odegard, Her-Shyong Shiah, Michael Kashgarian, Jennifer M. McNiff, David C. Baker, Yung-Chi Cheng, Joseph Craft, Abrogation of skin disease in LUPUS-prone MRL/FASlpr mice by means of a novel tylophorine analog, Arthritis & Rheumatism, 2006, 54, 10
    Direct Link:
View Full Article (HTML) Get PDF (230K)