• 1
    Astrom M, Rausing A. Chronic achilles tendinopathy: a survey of surgical and histopathologic findings. Clin Orthop 1995; 316: 15164.
  • 2
    Movin T, Gad A, Reinholt FP, Rolf C. Tendon pathology in long-standing achillodynia: biopsy findings in 40 patients. Acta Orthop Scand 1997; 68: 1705.
  • 3
    Kannus P, Jozsa L. Histopathological changes preceding spontaneous rupture of a tendon: a controlled study of 891 patients. J Bone Joint Surg Am 1991; 73: 150725.
  • 4
    Riley G. The pathogenesis of tendinopathy: a molecular perspective. Rheumatology (Oxford) 2004; 43: 13142.
  • 5
    Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001; 17: 463516.
  • 6
    Cawston T. Matrix metalloproteinases and TIMPs: properties and implications for the rheumatic diseases. Mol Med Today 1998; 4: 1307.
  • 7
    Riley GP, Curry V, DeGroot J, van El B, Verzijl N, Hazleman BL, et al. Matrix metalloproteinase activities and their relationship with collagen remodelling in tendon pathology. Matrix Biol 2002; 21: 18595.
  • 8
    Killar L, White J, Black R, Peschon J. Adamalysins: a family of metzincins including TNFα converting enzyme. Ann N Y Acad Sci 1999; 878: 44252.
  • 9
    Primakoff P, Myles DG. The ADAM gene family: surface proteins with adhesion and protease activity. Trends Genet 2000; 16: 837.
  • 10
    Black RA, Rauch CT, Kozlosky CJ, Peschon JJ, Slack JL, Wolfson MF, et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells. Nature 1997; 385: 72933.
  • 11
    Malfait AM, Liu RQ, Ijiri K, Komiya S, Tortorella MD. Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage. J Biol Chem 2002; 277: 222018.
  • 12
    Rees SG, Flannery CR, Little CB, Hughes CE, Caterson B, Dent CM. Catabolism of aggrecan, decorin and biglycan in tendon. Biochem J 2000; 350: 1818.
  • 13
    Jones GC, Riley GP. ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arthritis Res Ther 2005; 7: 1609.
  • 14
    Sandy JD, Neame PJ, Boynton RE, Flannery CR. Catabolism of aggrecan in cartilage explants: identification of a major cleavage site within the interglobular domain. J Biol Chem 1991; 266: 86835.
  • 15
    Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, et al. Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites. J Biol Chem 2000; 275: 3888590.
  • 16
    Sandy JD, Westling J, Kenagy RD, Iruela-Arispe ML, Verscharen C, Rodriguez-Mazaneque JC, et al. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J Biol Chem 2001; 276: 133728.
  • 17
    Somerville RP, Longpre JM, Jungers KA, Engle JM, Ross M, Evanko S, et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem 2003; 278: 950313.
  • 18
    Dickinson SC, Vankemmelbeke MN, Buttle DJ, Rosenberg K, Heinegard D, Hollander AP. Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs. Matrix Biol 2003; 22: 26778.
  • 19
    Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, et al. Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem 2004; 279: 1010919.
  • 20
    Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002; 115: 371927.
  • 21
    Amour A, Slocombe PM, Webster A, Butler M, Knight CG, Smith BJ, et al. TNFα converting enzyme is inhibited by TIMP-3. FEBS Lett 1998; 435: 3944.
  • 22
    Amour A, Knight CG, Webster A, Slocombe PM, Stephens PE, Knauper V, et al. The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Lett 2000; 473: 2759.
  • 23
    Kashiwagi M, Tortorella M, Nagase H, Brew K. TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem 2001; 276: 125014.
  • 24
    Ireland D, Harrall R, Curry V, Holloway G, Hackney R, Hazleman B, et al. Multiple changes in gene expression in chronic human Achilles tendinopathy. Matrix Biol 2001; 20: 15969.
  • 25
    Nuttall RK, Pennington CJ, Taplin J, Wheal A, Yong VW, Forsyth PA, et al. Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells. Mol Cancer Res 2003; 1: 33345.
  • 26
    Porter S, Scott SD, Sassoon EM, Williams MR, Jones JL, Girling AC, et al. Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma. Clin Cancer Res 2004; 10: 242940.
  • 27
    Conover WJ, Iman RL. Analysis of covariance using the rank transformation. Biometrics 1982; 38: 71524.
  • 28
    Jarvinen M, Jozsa L, Kannus P, Jarvinen TL, Kvist M, Leadbetter W. Histopathological findings in chronic tendon disorders. Scand J Med Sci Sports 1997; 7: 8695.
  • 29
    Alfredson H, Ohberg L, Forsgren S. Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections. Knee Surg Sports Traumatol Arthrosc 2003; 11: 3348.
  • 30
    Jozsa L, Kannus P. Overuse injuries in tendons. In: JozsaL, KannusP, editors. Human tendons: anatomy, physiology and pathology. Champaign (IL): Human Kinetics; 1997. p. 164253.
  • 31
    Archambault J, Tsuzaki M, Herzog W, Banes AJ. Stretch and interleukin-1β induce matrix metalloproteinases in rabbit tendon cells in vitro. J Orthop Res 2002; 20: 369.
  • 32
    Tsuzaki M, Bynum D, Almekinders L, Yang X, Faber J, Banes AJ. ATP modulates load-inducible IL-1β, COX 2, and MMP-3 gene expression in human tendon cells. J Cell Biochem 2003; 89: 55662.
  • 33
    Lavagnino M, Arnoczky SP, Tian T, Vaupel Z. Effect of amplitude and frequency of cyclic tensile strain on the inhibition of MMP-1 mRNA expression in tendon cells: an in vitro study. Connect Tissue Res 2003; 44: 1817.
  • 34
    Arnoczky SP, Tian T, Lavagnino M, Gardner K. Ex vivo static tensile loading inhibits MMP-1 expression in rat tail tendon cells through a cytoskeletally based mechanotransduction mechanism. J Orthop Res 2004; 22: 32833.
  • 35
    Tipton CM, Vailas AC, Matthes RD. Experimental studies on the influences of physical activity on ligaments, tendons and joints: a brief review. Acta Med Scand Suppl 1986; 711: 15768.
  • 36
    Yasuda K, Hayashi K. Changes in biomechanical properties of tendons and ligaments from joint disuse. Osteoarthritis Cartilage 1999; 7: 1229.
  • 37
    Hannafin JA, Arnoczky SP, Hoonjan A, Torzilli PA. Effect of stress deprivation and cyclic tensile loading on the material and morphologic properties of canine flexor digitorum profundus tendon: an in vitro study. J Orthop Res 1995; 13: 90714.
  • 38
    Majima T, Marchuk LL, Shrive NG, Frank CB, Hart DA. In-vitro cyclic tensile loading of an immobilized and mobilized ligament autograft selectively inhibits mRNA levels for collagenase (MMP-1). J Orthop Sci 2000; 5: 50310.
  • 39
    Drummond AH, Beckett P, Brown PD, Bone EA, Davidson AH, Galloway WA, et al. Preclinical and clinical studies of MMP inhibitors in cancer. Ann N Y Acad Sci 1999; 878: 22835.
  • 40
    Van Meurs J, van Lent P, Stoop R, Holthuysen A, Singer I, Bayne E, et al. Cleavage of aggrecan at the Asn341–Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity. Arthritis Rheum 1999; 42: 207484.
  • 41
    Van Meurs J, van Lent P, Holthuysen A, Lambrou D, Bayne E, Singer I, et al. Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction. J Immunol 1999; 163: 56339.
  • 42
    Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R. The collagenase gene family in humans consists of at least four members. Biochem J 1988; 253: 18792.
  • 43
    Loechel F, Fox JW, Murphy G, Albrechtsen R, Wewer UM. ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. Biochem Biophys Res Commun 2000; 278: 5115.
  • 44
    Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med 2002; 8: 3540.
  • 45
    Kurisaki T, Masuda A, Sudo K, Sakagami J, Higashiyama S, Matsuda Y, et al. Phenotypic analysis of meltrin α (ADAM12)-deficient mice: involvement of meltrin α in adipogenesis and myogenesis. Mol Cell Biol 2003; 23: 5561.
  • 46
    Roy R, Wewer UM, Zurakowski D, Pories SE, Moses MA. ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage. J Biol Chem 2004; 279: 5132330.
  • 47
    Iba K, Albrechtsen R, Gilpin BJ, Loechel F, Wewer UM. Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell adhesion. Am J Pathol 1999; 154: 1489501.
  • 48
    Iba K, Albrechtsen R, Gilpin B, Frohlich C, Loechel F, Zolkiewska A, et al. The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to β1 integrin-dependent cell spreading. J Cell Biol 2000; 149: 114356.
  • 49
    Thodeti CK, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, et al. ADAM12/syndecan-4 signaling promotes β1 integrin-dependent cell spreading through protein kinase Cα and RhoA. J Biol Chem 2003; 278: 957684.
  • 50
    Riley GP, Harrall RL, Cawston TE, Hazleman BL, Mackie EJ. Tenascin-C and human tendon degeneration. Am J Pathol 1996; 149: 93343.
  • 51
    Pei D. CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch. FEBS Lett 1999; 457: 26270.
  • 52
    Velasco G, Pendas AM, Fueyo A, Knauper V, Murphy G, Lopez-Otin C. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. J Biol Chem 1999; 274: 45706.
  • 53
    Clancy BM, Johnson JD, Lambert AJ, Rezvankhah S, Wong A, Resmini C, et al. A gene expression profile for endochondral bone formation: oligonucleotide microarrays establish novel connections between known genes and BMP-2-induced bone formation in mouse quadriceps. Bone 2003; 33: 4663.
  • 54
    Fenwick S, Harrall R, Hackney R, Bord S, Horner A, Hazleman B, et al. Endochondral ossification in Achilles and patella tendinopathy. Rheumatology (Oxford) 2002; 41: 4746.
  • 55
    Hashimoto G, Aoki T, Nakamura H, Tanzawa K, Okada Y. Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4). FEBS Lett 2001; 494: 1925.
  • 56
    BenEzra D. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3. Invest Ophthalmol Vis Sci 1997; 38: 24334.
  • 57
    Ma DH, Chen JI, Zhang F, Hwang DG, Chen JK. Inhibition of fibroblast-induced angiogenic phenotype of cultured endothelial cells by the overexpression of tissue inhibitor of metalloproteinase (TIMP)-3. J Biomed Sci 2003; 10: 52634.
  • 58
    Yu JS, Popp JE, Kaeding CC, Lucas J. Correlation of MR imaging and pathologic findings in athletes undergoing surgery for chronic patellar tendinitis. AJR Am J Roentgenol 1995; 165: 1158.
  • 59
    Bjur D, Alfredson H, Forsgren S. The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation. Cell Tissue Res 2005; 320: 2016.
  • 60
    Alfredson H. The chronic painful Achilles and patellar tendon: research on basic biology and treatment. Scand J Med Sci Sports 2005; 15: 2529.
  • 61
    Lo IK, Marchuk LL, Hollinshead R, Hart DA, Frank CB. Matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase mRNA levels are specifically altered in torn rotator cuff tendons. Am J Sports Med 2004; 32: 12239.
  • 62
    Brew K, Dinakarpandian D, Nagase H. Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta 2000; 1477: 26783.
  • 63
    Sedlacek R, Mauch S, Kolb B, Schatzlein C, Eibel H, Peter HH, et al. Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis. Immunobiology 1998; 198: 40823.
  • 64
    Pendas AM, Knauper V, Puente XS, Llano E, Mattei MG, Apte S, et al. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J Biol Chem 1997; 272: 42816.
  • 65
    Mueller MS, Mauch S, Sedlacek R. Structure of the human MMP-19 gene. Gene 2000; 252: 2737.
  • 66
    Hieta N, Impola U, Lopez-Otin C, Saarialho-Kere U, Kahari VM. Matrix metalloproteinase-19 expression in dermal wounds and by fibroblasts in culture. J Invest Dermatol 2003; 121: 9971004.