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Quality of life and psychological status in patients with primary Sjögren's syndrome and sicca symptoms without autoimmune features

  1. Julien Champey1,†,
  2. Emmanuelle Corruble1,†,
  3. Jacques-eric Gottenberg1,
  4. Catherine Buhl1,
  5. Tania Meyer1,
  6. Céline Caudmont1,
  7. Elisabeth Bergé1,
  8. Jacques Pellet2,
  9. Patrick Hardy1,
  10. Xavier Mariette1,*

Article first published online: 31 MAY 2006

DOI: 10.1002/art.21990

Issue

Arthritis Care & Research

Arthritis Care & Research

Volume 55, Issue 3, pages 451–457, 15 June 2006

Additional Information

How to Cite

Champey, J., Corruble, E., Gottenberg, J.-e., Buhl, C., Meyer, T., Caudmont, C., Bergé, E., Pellet, J., Hardy, P. and Mariette, X. (2006), Quality of life and psychological status in patients with primary Sjögren's syndrome and sicca symptoms without autoimmune features. Arthritis Care & Research, 55: 451–457. doi: 10.1002/art.21990

Author Information

  1. 1

    Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Université Paris-11, Le Kremlin Bicêtre, France

  2. 2

    Centre hospitalo-universitaire (CHU), St. Etienne, France

  1. †

    Drs. Champey and Corruble participated equally in this work.

*Service de Rhumatologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France

Publication History

  1. Issue published online: 31 MAY 2006
  2. Article first published online: 31 MAY 2006
  3. Manuscript Accepted: 18 OCT 2005
  4. Manuscript Received: 30 MAY 2005

Funded by

  • Association Française du Gougerot Sjögren et des syndromes secs

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Keywords:

  • Sjögren's syndrome;
  • Quality of life;
  • Depression;
  • Anxiety

Abstract

Objective

To compare pain, fatigue, and sicca symptoms; quality of life; and psychological status between patients with primary Sjögren's syndrome (SS) and those with sicca symptoms but no autoimmune features (sicca asthenia polyalgia syndrome [SAPS]), and to determine whether a psychological pattern can be detected in patients with SAPS, which could suggest psychological distress as the cause.

Methods

This cross-sectional, prospective study included 111 patients with primary SS according to the American-European Consensus Group criteria and 65 SAPS patients with no focus on lip biopsy and no anti-SSA/SSB antibodies. Pain, fatigue, and sicca symptoms were assessed using visual analog scales; quality of life was assessed using the Short Form 36 (SF-36); and psychological distress by the Symptom Checklist-90-Revised (SCL-90-R) questionnaire.

Results

No difference was observed between primary SS and SAPS patients for pain, fatigue, sicca symptoms, quality of life, and psychological status. Fatigue and pain, but not dryness, were correlated with both quality of life and psychological distress in both groups. For primary SS patients, physical and mental composite scores on the SF-36 correlated well with global severity index (GSI) scores of the SCL-90-R (r = −0.29, P = 0.006 and r = −0.61, P < 0.0001, respectively).

Conclusion

Patients with primary SS and SAPS do not differ in quality of life or psychological status. Although both diseases probably have a different origin, they may require the same psychological support or psychiatric care. The strong correlation between the composite physical and mental scores of the SF-36 and the GSI scores of the SCL-90-R in primary SS patients emphasizes the importance of the psychological dimension in results of the SF-36.

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