Research Article
You have full text access to this OnlineOpen article
Anti–N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus
Article first published online: 25 JUL 2006
DOI: 10.1002/art.22031
Copyright © 2006 by the American College of Rheumatology
Additional Information
How to Cite
Lapteva, L., Nowak, M., Yarboro, C. H., Takada, K., Roebuck-Spencer, T., Weickert, T., Bleiberg, J., Rosenstein, D., Pao, M., Patronas, N., Steele, S., Manzano, M., van der Veen, J. W. C., Lipsky, P. E., Marenco, S., Wesley, R., Volpe, B., Diamond, B. and Illei, G. G. (2006), Anti–N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus. Arthritis & Rheumatism, 54: 2505–2514. doi: 10.1002/art.22031
Publication History
- Issue published online: 25 JUL 2006
- Article first published online: 25 JUL 2006
- Manuscript Accepted: 8 MAY 2006
- Manuscript Received: 27 JUL 2005
Funded by
- Intramural Research Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
- Abstract
- Article
- References
- Cited By
Cited in:
- CrossRef
This article has been cited by:
- 1, , , , , A Prospective Functional MRI Study for Executive Function in Patients with Systemic Lupus Erythematosus Without Neuropsychiatric Symptoms, Seminars in Arthritis and Rheumatism, 2012, 41, 6, 849
- 2, , , , Biomarkers for systemic lupus erythematosus, Translational Research, 2012, 159, 4, 326
- 3, , , Cognitive impairment in non-neuropsychiatric systemic lupus erythematosus, The Egyptian Rheumatologist, 2012, 34, 2, 67
- 4, , , , , , , , , Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus, Rheumatology, 2011, 50, 9, 1578
- 5, , Autoimmune and inflammatory mechanisms of CNS damage, Progress in Neurobiology, 2011, 95, 3, 301
- You have free access to this content6, , , , , , , Cardiovascular and disease-related predictors of depression in systemic lupus erythematosus, Arthritis Care & Research, 2011, 63, 4Direct Link:
- 7, , Lupus neuropsychiatrique et auto anticorps dirigés contre le récepteur ionotrope activé par le glutamate (R-NMDA), La Revue de Médecine Interne, 2011, 32, 2, 130
- 8, , Managing CNS involvement in systemic lupus erythematosus, International Journal of Clinical Rheumatology, 2011, 6, 5, 547
- 9, , , , , Memantine in Systemic Lupus Erythematosus: A Randomized, Double-Blind Placebo-Controlled Trial, Seminars in Arthritis and Rheumatism, 2011, 41, 2, 194
- You have free access to this content10, , , , , , Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus, Journal of Internal Medicine, 2011, 269, 1Direct Link:
- 11, , , , , , , , , Neurocognitive impairment in childhood-onset systemic lupus erythematosus: Measurement issues in diagnosis, Arthritis Care & Research, 2011, 63, 8Direct Link:
- 12, , , Neuropsychiatric Manifestations in Systemic Lupus Erythematosus, CNS Drugs, 2011, 25, 9, 721
- 13, , , , , , , , , NR2-reactive antibody decreases cell viability through augmentation of Ca2+ influx in systemic lupus erythematosus, Arthritis & Rheumatism, 2011, 63, 12Direct Link:
- 14, , Systemic lupus erythematosus, the brain, and anti-NR2 antibodies, Journal of Neurology, 2011, 259, 4, 622
- 15, , The MRL/lpr Mouse Strain as a Model for Neuropsychiatric Systemic Lupus Erythematosus, Journal of Biomedicine and Biotechnology, 2011, 2011, 1
- 16
- 17
- 18
- 19, , , , , , , , , , , Anti–U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease, Arthritis & Rheumatism, 2010, 62, 12Direct Link:
- 20, , , , , , , , , Antibodies against N-methyl-D-aspartate receptors in patients with systemic lupus erythematosus without major neuropsychiatric syndromes, Journal of the Neurological Sciences, 2010, 295, 1-2, 87
- 21, , , , , , , , , Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus, Journal of Neuroimmunology, 2010, 223, 1-2, 13
- 22, , , Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus, Rheumatic Disease Clinics of North America, 2010, 36, 1, 187
- 23, , , , , Intrathecal antibodies and brain damage in autoimmune MRL mice, Brain, Behavior, and Immunity, 2010, 24, 2, 289
- 24, , Neurologic Manifestations of Systemic Lupus Erythematosus in Children and Adults, Neurologic Clinics, 2010, 28, 1, 61
- 25, , , , , , , , , , , , Neurotoxic lupus autoantibodies alter brain function through two distinct mechanisms, Proceedings of the National Academy of Sciences, 2010, 107, 43, 18569
- 26, , Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations, Nature Reviews Rheumatology, 2010, 6, 6, 358
- 27, , Role for antibodies in altering behavior and movement, Autism Research, 2010, 3, 4Direct Link:
- 28, , , , , , , Depression is an early disease manifestation in lupus-prone MRL/lpr mice, Journal of Neuroimmunology, 2009, 207, 1-2, 45
- 29, , , , , Losing your nerves? Maybe it's the antibodies, Nature Reviews Immunology, 2009, 9, 6, 449
- 30, , Pathogenesis of neuropsychiatric systemic lupus erythematosus and potential biomarkers, Modern Rheumatology, 2009, 19, 5, 457
- 31, , , , , , , Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study, International Journal of Epidemiology, 2009, 38, 4, 1049
- 32, , The search for lupus biomarkers, Best Practice & Research Clinical Rheumatology, 2009, 23, 4, 507
- 33
- 34, , , , , , Abetimus sodium for renal flare in systemic lupus erythematosus: Results of a randomized, controlled phase III trial, Arthritis & Rheumatism, 2008, 58, 8Direct Link:
- 35, , , , , Acute pan-dysautonomia as well as central nervous system involvement and peripheral neuropathies in a patient with systemic lupus erythematosus, Modern Rheumatology, 2008, 18, 5, 516
- 36, , , , , , , , , , Association between depression and coronary artery calcification in women with systemic lupus erythematosus, Rheumatology, 2008, 48, 5, 576
- 37, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: Results from an international inception cohort study, Arthritis & Rheumatism, 2008, 58, 3Direct Link:
- 38, , Autoantibodies to glutamate receptors can damage the brain in epilepsy, systemic lupus erythematosus and encephalitis, Expert Review of Neurotherapeutics, 2008, 8, 7, 1141
- 39, , , , , Autoantibody-mediated neuroinflammation: Pathogenesis of neuropsychiatric systemic lupus erythematosus in the NZM88 murine model, Brain, Behavior, and Immunity, 2008, 22, 6, 949
- 40, , , , Cognitive dysfunction in systemic lupus erythematosus: Past, present, and future, Arthritis & Rheumatism, 2008, 58, 11Direct Link:
- 41
- 42, , , , , , , Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus, Nature Medicine, 2008, 15, 1, 91
- 43
- 44, , The mosaic of schizophrenia: Has the time arrived to monitor the illness with biomarkers?, Clinical Biochemistry, 2008, 41, 6, 353
- 45, Advances in understanding newer autoantibodies and their role as biomarkers in systemic lupus erythematosus, Expert Opinion on Medical Diagnostics, 2007, 1, 3, 393
- 46, , , , , , , , , , , Antiribosomal-P autoantibodies from psychiatric lupus target a novel neuronal surface protein causing calcium influx and apoptosis, Journal of Experimental Medicine, 2007, 204, 13, 3221
- 47, , , , , , , , Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus: A pilot study, Arthritis & Rheumatism, 2007, 56, 12Direct Link:
- 48, , , , , , , , , Impact of memory impairment on employment status in persons with systemic lupus erythematosus, Arthritis Care & Research, 2007, 57, 8Direct Link:
- 49, , Late Consequences of Chronic Pediatric Illness, Psychiatric Clinics of North America, 2007, 30, 4, 819
- 50, New insights into central nervous system lupus: A clinical perspective, Current Rheumatology Reports, 2007, 9, 2, 116
- 51, , , , , , , , , , , , , , , Paraneoplastic anti–N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma, Annals of Neurology, 2007, 61, 1Direct Link:
- 52, , , , Psychiatric manifestations in systemic lupus erythematosus, Autoimmunity Reviews, 2007, 6, 6, 421
- 53, Quoi de neuf en médecine en 2007 ?, Annales de Dermatologie et de Vénéréologie, 2007, 134, 8S24
- 54, , The biology behind the new therapies for SLE, International Journal of Clinical Practice, 2007, 61, 12Direct Link:
- 55Antibodies to NMDA receptor 2 linked with depression in patients with SLE, Nature Clinical Practice Rheumatology, 2006, 2, 11, 579
- 56, Fulfilling Koch's postulates of autoimmunity: Anti-NR2 antibodies in mice and men, Arthritis & Rheumatism, 2006, 54, 8Direct Link:

1529-0131/asset/olbannerleft.gif?v=1&s=897b81612b4ad6cae003112184adc709261d5f61)
1529-0131/asset/olbannerright.gif?v=1&s=04654f5ea3cbb01656383e0c0d04b16fd0a9a896)
1529-0131/asset/cover.gif?v=1&s=104d5c2bb8ef72deba26790b855af7ab80697a0e)