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Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope

  1. Song Ling1,†,
  2. Angela Lai1,
  3. Olga Borschukova2,
  4. Paul Pumpens2,
  5. Joseph Holoshitz1,†,‡,*

Article first published online: 30 OCT 2006

DOI: 10.1002/art.22178

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 54, Issue 11, pages 3423–3432, November 2006

Additional Information

How to Cite

Ling, S., Lai, A., Borschukova, O., Pumpens, P. and Holoshitz, J. (2006), Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope. Arthritis & Rheumatism, 54: 3423–3432. doi: 10.1002/art.22178

Author Information

  1. 1

    University of Michigan, Ann Arbor

  2. 2

    Biomedical Research and Study Center, University of Latvia, Riga, Latvia

  1. †

    Drs. Ling and Holoshitz have a US patent for USPTO 7,074,893.

  2. ‡

    Dr. Holoshitz receives licensing fees for an unrelated technology from Protein Design Laboratories through the Stanford Technology Office.

*Department of Internal Medicine, University of Michigan, 1150 West Medical Center Drive, 5520 MSRB I, Ann Arbor, MI 48109-0680

Publication History

  1. Issue published online: 30 OCT 2006
  2. Article first published online: 30 OCT 2006
  3. Manuscript Accepted: 26 JUL 2006
  4. Manuscript Received: 4 APR 2006

Funded by

  • NIH. Grant Numbers: AI-47331, AR-46468, AR-20557
  • Arthritis Foundation (Innovative Research Grant)
  • University of Michigan Biotechnology Development Fund

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    Shirly Naveh, Yftah Tal-Gan, Song Ling, Amnon Hoffman, Joseph Holoshitz, Chaim Gilon, Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leads, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 1, 493

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    Shimon Sakaguchi, Helen Benham, Andrew P Cope, Ranjeny Thomas, T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man, Immunology and Cell Biology, 2012, 90, 3, 277

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    Denise E. de Almeida, Song Ling, Joseph Holoshitz, New insights into the functional role of the rheumatoid arthritis shared epitope, FEBS Letters, 2011, 585, 23, 3619

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    Joseph Holoshitz, Denise E. De Almeida, Song Ling, A role for calreticulin in the pathogenesis of rheumatoid arthritis, Annals of the New York Academy of Sciences, 2010, 1209, 1
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    Darren C. Phillips, H.K. Irundika Dias, George D. Kitas, Helen R. Griffiths, Aberrant Reactive Oxygen and Nitrogen Species Generation in Rheumatoid Arthritis (RA): Causes and Consequences for Immune Function, Cell Survival, and Therapeutic Intervention, Antioxidants & Redox Signaling, 2010, 12, 6, 743

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    Joanna M. Tarr, Paul G. Winyard, Brent Ryan, Lorna W. Harries, Richard Haigh, Nick Viner, Paul Eggleton, Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)–mediated apoptosis of T cells, Arthritis & Rheumatism, 2010, 62, 10
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    Ugo Fiocco, Paolo Sfriso, Francesca Oliviero, Elisa Pagnin, Elena Scagliori, Carla Campana, Serena Dainese, Luisella Cozzi, Leonardo Punzi, Co-stimulatory modulation in rheumatoid arthritis: The role of (CTLA4-Ig) abatacept, Autoimmunity Reviews, 2008, 8, 1, 76

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