Dr. Finckh received an unrestricted research grant (more than $10,000) from Wyeth (Switzerland).
Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women
Article first published online: 30 OCT 2006
Copyright © 2006 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 54, Issue 11, pages 3648–3654, November 2006
How to Cite
Finckh, A., Cooper, G. S., Chibnik, L. B., Costenbader, K. H., Watts, J., Pankey, H., Fraser, P. A. and Karlson, E. W. (2006), Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban women. Arthritis & Rheumatism, 54: 3648–3654. doi: 10.1002/art.22210
- Issue published online: 30 OCT 2006
- Article first published online: 30 OCT 2006
- Manuscript Accepted: 9 AUG 2006
- Manuscript Received: 10 MAR 2006
- Kirkland Scholars Fellowship
- Centocor Health Outcomes in Rheumatic Diseases Fellowship
- NIH. Grant Numbers: P60-AR-47782, R01-AR-49880, P60-AR-4778, K24-AR-0524-01, R01-AR-49880
- Intramural Research Program of the National Institute of Environmental Health Sciences
- Arthritis Investigator Award from the American College of Rheumatology and the Arthritis Foundation
- National Institute of Environmental Health Sciences. Grant Number: R25-ES-10457-01
To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population.
Women with SLE were identified through both community screening and hospital databases in 4 predominantly African American neighborhoods in Boston. Female control patients were volunteers from the same communities and were screened for the absence of connective tissue disease. Demographic factors, smoking history, and a detailed occupational history, including exposures to specific chemicals, were obtained by in-person interviews. The exposure assessment was based on independent evaluation of the occupational history by 2 reviewers who were blinded to each subject's disease status. The risks associated with exposure to silica and solvents were analyzed using multivariate conditional logistic regression models, adjusted for potential confounders.
Ninety-five patients and 191 age- and race-matched controls were included in this analysis. Exposure to silica for longer than 1 year was associated with SLE (odds ratio [OR] 4.3, 95% confidence interval [95% CI] 1.7–11.2). An exposure-response effect was seen for longer duration of exposures to silica (P for trend = 0.01). The association between occupational exposure to organic solvents and SLE was not statistically significant (OR 1.04, 95% CI 0.34–3.2).
Silica exposure from a variety of industrial occupations in urban areas is associated with an increased risk of SLE. A longer duration of exposure to silica dust is associated with greater risks. This study provides further impetus for additional research into the influence of modifiable exposures on the pathogenesis of SLE.