Dr. Straub has received consulting fees (less than $10,000) from Merck, Germany.
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Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management
Article first published online: 30 JAN 2007
DOI: 10.1002/art.22368
Copyright © 2007 by the American College of Rheumatology
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How to Cite
Straub, R. H. and Cutolo, M. (2007), Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management. Arthritis & Rheumatism, 56: 399–408. doi: 10.1002/art.22368
Publication History
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Manuscript Accepted: 23 OCT 2006
- Manuscript Received: 29 JUL 2006
REFERENCES
- 1. The quantitative measurement of joint changes in rheumatoid arthritis. Ann Phys Med 1968; 9: 322–7.
- 2, , , . Domiciliary self-measurement in the rheumatoid arthritis and the demonstration of circadian rhythmicity. Ann Rheum Dis 1982; 41: 453–5.
- 3, , , , , , et al. Circadian variation in disease activity in rheumatoid arthritis. Br Med J (Clin Res Ed) 1982; 284: 551–4.
- 4, , , . Circadian rhythm in pain, stiffness, and manual dexterity in rheumatoid arthritis: relation between discomfort and disability. Ann Rheum Dis 1991; 50: 243–8.
- 5, , . Variability of immunologic and clinical features in patients with rheumatoid arthritis studied over 24 hours. J Rheumatol 1993; 20: 940–3.
- 6, , , . The experience of rheumatoid arthritis pain and fatigue: examining momentary reports and correlates over one week. Arthritis Care Res 1997; 10: 185–93.Direct Link:
- 7, . Circadian rhythms and arthritis. Rheum Dis Clin North Am 2005; 31: 115–29, ix–x.
- 8
- 9, . Diurnal periodicity of cortisol secretion, immune reactivity and disease activity in rheumatoid arthritis: implications for steroid treatment. Br J Rheumatol 1989; 28: 154–7.
- 10, , , , . Circadian rhythms in RA. Ann Rheum Dis 2003; 62: 593–6.
- 11, , , . The timing of glucocorticoid administration in rheumatoid arthritis. Ann Rheum Dis 1997; 56: 27–31.
- 12, . A retinohypothalamic projection in the rat. J Comp Neurol 1972; 146: 1–14.Direct Link:
- 13, , . An autoradiographic and electron microscopic study of retino-hypothalamic connections. Z Zellforsch Mikrosk Anat 1972; 135: 1–26.
- 14, . Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Res 1972; 42: 201–6.
- 15, , , , , . Circadian rhythmicity restored by neural transplant: immunocytochemical characterization of the graft and its integration with the host brain. J Neurosci 1987; 7: 1626–38.
- 16, , , . The hypothalamic integrator for circadian rhythms. Trends Neurosci 2005; 28: 152–7.
- 17, . Coordination of circadian timing in mammals. Nature 2002; 418: 935–41.
- 18, , , , , , et al. Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms. Cell 1984; 38: 701–10.
- 19, , , , , , et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 1994; 264: 719–25.
- 20. Clock genes in cell clocks: roles, actions, and mysteries. J Biol Rhythms 2004; 19: 388–99.
- 21, , , , , , et al. The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol 2005; 289: H1530–41.
- 22, , , , , , et al. Adrenergic regulation of clock gene expression in mouse liver. Proc Natl Acad Sci U S A 2003; 100: 6795–800.
- 23, , , , , . Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood 2003; 102: 4143–5.
- 24, . Circadian oscillations of clock genes, cytolytic factors, and cytokines in rat NK cells. J Immunol 2005; 174: 7618–24.
- 25, , , , , . Anti-inflammatory cooperativity of corticosteroids and norepinephrine in rheumatoid arthritis synovial tissue in vivo and in vitro. FASEB J 2002; 16: 993–1000.
- 26, , , , , . Circadian cycle of urinary cortisol in healthy subjects and in Cushing's syndrome. J Clin Endocrinol Metab 1965; 25: 1331–9.
- 27, , , , , . Circadian rhythm of in vitro bone-resorbing activity in human serum. J Clin Endocrinol Metab 1995; 80: 3185–90.
- 28, , , , . Adrenal secretion of cortisol in patients with rheumatoid arthritis. J Rheumatol 1990; 17: 24–9.
- 29, , , , . Diurnal rhythm of salivary cortisol levels in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 2000; 43: 465–7.Direct Link:
- 30. Effects of Freund's complete adjuvant on the diurnal rhythms of neuroendocrine processes and ornithine decarboxylase activity in various tissues of male rats. Experientia 1996; 52: 900–8.
- 31, , , , . Circadian rhythms in adenohypophysial hormone levels and hypothalamic monoamine turnover in mycobacterial-adjuvant-injected rats. Biol Signals Recept 1998; 7: 15–24.
- 32, , , . Chronic activation of the hypothalamo-pituitary-adrenal axis and loss of circadian rhythm during adjuvant-induced arthritis in the rat. Endocrinology 1992; 130: 1775–9.
- 33
- 34, , , , , , et al. Melatonin influences interleukin-12 and nitric oxide production by primary cultures of rheumatoid synovial macrophages and THP-1 cells. Ann N Y Acad Sci 1999; 876: 246–54.Direct Link:
- 35, , . Pineal gland in autoimmunity: melatonin-dependent exaggeration of collagen-induced arthritis in mice. Autoimmunity 1994; 17: 83–6.
- 36
- 37. Estrogen, prolactin, and autoimmunity: actions and interactions. Int Immunopharmacol 2001; 1: 995–1008.
- 38, . Roles of prolactin and gonadotropin-releasing hormone in rheumatic diseases. Rheum Dis Clin North Am 2000; 26: 713–36.
- 39, , , , , , et al. Melatonin serum levels in rheumatoid arthritis. Ann N Y Acad Sci 2002; 966: 276–83.Direct Link:
- 40, , , , , , et al. Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison. Ann Rheum Dis 2005; 64: 212–6.
- 41, , , , . Excessive and dysregulated secretion of prolactin in rheumatoid arthritis: immunopathogenetic and therapeutic implications. Br J Rheumatol 1993; 32: 445–8.
- 42, , , , , , et al. ACTH, cortisol and prolactin in active rheumatoid arthritis. Clin Rheumatol 2002; 21: 289–93.
- 43, . The melatonin-cytokine connection in rheumatoid arthritis. Ann Rheum Dis 2005; 64: 1109–11.
- 44, , , . Gender, biology and human disease: report of a conference. Lupus 1999; 8: 335–8.
- 45, , , , , , et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 2004; 89: 2119–26.
- 46
- 47
- 48
- 49, , , , . Circadian variation in variant angina. Am J Cardiol 1984; 54: 61–4.
- 50, , , , , . Circadian pattern in occurrence of renal colic in an emergency department: analysis of patients' notes. BMJ 2002; 324: 767.
- 51, , , , . Circadian variation in the onset of myocardial infarction: effect of duration of diabetes. Diabetes 2003; 52: 1464–8.
- 52, , , , , , et al. Circadian interrelationships among levels of plasma fibrinogen, blood platelets, and serum interleukin-6. Clin Appl Thromb Hemost 1999; 5: 37–42.
- 53, , , , . Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol 1997; 158: 4454–64.
- 54, , . Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications. Cytokine 1998; 10: 307–12.
- 55, , , , , , et al. Endogenous cortisol determines the circadian rhythm of lipopolysaccharide—but not lipoteichoic acid—inducible cytokine release. Eur J Immunol 2006; 36: 371–9.Direct Link:
- 56, , , . Sleep-like concentrations of growth hormone and cortisol modulate type1 and type2 in-vitro cytokine production in human T cells. Int Immunopharmacol 2006; 6: 216–25.
- 57, , , . The sympathetic nervous system—an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000; 52: 595–638.
- 58, , , , , . Circadian and diurnal variation of circulating immune complexes, complement-mediated solubilization, and the complement split product C3d in rheumatoid arthritis. Scand J Rheumatol 1986; 15: 113–8.
- 59, , , , , , et al. Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J Clin Endocrinol Metab 1997; 82: 1279–83.
- 60, , , , , , et al. Circadian variation of autonomic nervous activity in patients with multivessel coronary spasm. Jpn Circ J 2001; 65: 593–8.
- 61, . Involvement of the hypothalamic–pituitary–adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role [review]. Arthritis Rheum 2001; 44: 493–507.Direct Link:
- 62, , . Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents. J Neurophysiol 1989; 62: 48–58.
- 63, . Afferent and spinal mechanisms of joint pain. Pain 1993; 55: 5–54.
- 64, . Beyond neurons: evidence that immune and glial cells contribute to pathological pain states. Physiol Rev 2002; 82: 981–1011.
- 65, . On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders. J Clin Endocrinol Metab 2005; 90: 3106–14.
- 66, . Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases. FASEB J 2003; 17: 2176–83.
- 67, , . Bioenergetics of immune functions: fundamental and therapeutic aspects. Immunol Today 2000; 21: 192–9.
- 68. Quantitation of activity of rheumatoid arthritis: method for summation of systemic indices of rheumatoid activity. Am J Med Sci 1956; 232: 300–17.
- 69, , , , . Via β-adrenoceptors, stimulation of extrasplenic sympathetic nerve fibers inhibits lipopolysaccharide-induced TNF secretion in perfused rat spleen. J Neuroimmunol 2003; 145: 77–85.
- 70, , , Role of transcriptional activation of I κ B α in mediation of immunosuppression by glucocorticoids. Science 1995; 270: 283–6.
- 71, , , , . Induction of the E-selectin promoter by interleukin 1 and tumour necrosis factor α, and inhibition by glucocorticoids. Biochem J 1997; 328(Pt 2): 707–15.
- 72, . Orchestrating time: arrangements of the brain circadian clock. Trends Neurosci 2005; 28: 145–51.
- 73, , , , , . Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator. Immunol Cell Biol 2003; 81: 137–43.Direct Link:
- 74, , , , , . Circadian variation of granulocyte colony stimulating factor levels in man. Br J Haematol 1999; 106: 368–70.Direct Link:
- 75, , , , , , et al. Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. J Clin Endocrinol Metab 2005; 90: 2522–30.
- 76, , , , , . Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures. Psychoneuroendocrinology 2002; 27: 921–31.
- 77. Daily fluctuations in the plasma cortisol level of children with rheumatoid arthritis before and after treatment with tetracosactrin (‘Cortrosyn Depot’) and corticosteroid hormones. Curr Med Res Opin 1977; 4: 477–84.
- 78, , , . Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 1996; 153: 1080–6.
- 79, , , , . Circadian secretions of IL-2, IL-12, IL-6 and IL-10 in relation to the light/dark rhythm of the pineal hormone melatonin in healthy humans. Nat Immun 1998; 16: 1–5.
- 80, , , , . The role of granulocyte-macrophage-colony stimulating factor, cortisol, and melatonin in the regulation of the circadian rhythms of peripheral blood cells in healthy volunteers and patients with breast cancer. J Pineal Res 1999; 26: 1–8.Direct Link:
- 81, , , , . Circadian rhythms of women with fibromyalgia. J Clin Endocrinol Metab 2001; 86: 1034–9.
- 82, . Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance? J Immunol 1997; 158: 5163–8.
- 83, , , , . Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans. Brain Behav Immun 2004; 18: 341–8.
- 84, , , , , , et al. Alteration of opioid peptide circadian rhythm in cancer patients. Tumori 1988; 74: 357–60.
- 85, . Biological rhythms in pain and in the effects of opioid analgesics. Pharmacol Ther 1995; 68: 129–47.
- 86, , , . Rhythmic variations in pain, stiffness, and manual dexterity in hand osteoarthritis. Ann Rheum Dis 2002; 61: 1075–80.
- 87, , , , , , et al. Circadian fluctuations of melatonin, tumor necrosis factor-α and its soluble receptors in the circulation of patients with advanced gastrointestinal cancer. J Exp Clin Cancer Res 2003; 22: 171–8.
- 88, , , , , . IL-6 and its circadian secretion in humans. Neuroimmunomodulation 2005; 12: 131–40.
- 89, , , . Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans. J Clin Endocrinol Metab 2000; 85: 3597–603.
- 90, , , , , , et al. Circadian characteristics of circulating interleukin-6 in men. J Allergy Clin Immunol 1995; 95: 1029–35.
- 91, , , , . Sequential synovial fluid sampling suggests plasma and synovial fluid IL-6 vary independently in rheumatoid arthritis. Rheumatology (Oxford) 2006; 45: 229–30.

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