Dr. Herrero-Beaumont has received speaking fees (less than $10,000) from Rottapharm.
Research Article
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Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator†
Article first published online: 30 JAN 2007
DOI: 10.1002/art.22371
Copyright © 2007 by the American College of Rheumatology
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How to Cite
Herrero-Beaumont, G., Ivorra, J. A. R., del Carmen Trabado, M., Blanco, F. J., Benito, P., Martín-Mola, E., Paulino, J., Marenco, J. L., Porto, A., Laffon, A., Araújo, D., Figueroa, M. and Branco, J. (2007), Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis & Rheumatism, 56: 555–567. doi: 10.1002/art.22371
- †
ClinicalTrials.gov identifier: NCT00110474.
Publication History
- Issue published online: 30 JAN 2007
- Article first published online: 30 JAN 2007
- Manuscript Accepted: 23 OCT 2006
- Manuscript Received: 16 MAY 2006
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- 1, , , , , , , , , Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study, Osteoarthritis and Cartilage, 2012,
- 2, , , , , Effects of glucosamine sulfate and exercise therapy on serum leptin levels in patients with knee osteoarthritis: preliminary results of randomized controlled clinical trial, Rheumatology International, 2012,
- 3, , , Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?, Arthritis Research & Therapy, 2012, 14, 1, 201
- 4, , , , , Nanomaterials for the Local and Targeted Delivery of Osteoarthritis Drugs, Journal of Nanomaterials, 2012, 2012, 1
- 5
- 6, , , , , Role of glucosamine in the treatment for osteoarthritis, Rheumatology International, 2012,
- 7, , , , , , , , , , A Randomized Controlled Exploratory Evaluation of Standardized Ayurvedic Formulations in Symptomatic Osteoarthritis Knees: A Government of India NMITLI Project, Evidence-Based Complementary and Alternative Medicine, 2011, 2011, 1
- 8, , A review on the effects of glucosamine for knee osteoarthritis based on human and animal studies, Hong Kong Physiotherapy Journal, 2011, 29, 2, 42
- 9, Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids, International Journal of Rheumatology, 2011, 2011, 1
- 10, , , Non-surgical treatment of osteoarthritis-related pain in the elderly, Current Reviews in Musculoskeletal Medicine, 2011, 4, 3, 113
- 11, , , , , Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: Implications for human efficacy and toxicity, Archives of Biochemistry and Biophysics, 2011, 510, 1, 11
- 12, , , , The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature, Osteoarthritis and Cartilage, 2011, 19, 4, 375
- 13, , , , Use of glucosamine and chondroitin and lung cancer risk in the VITamins And Lifestyle (VITAL) cohort, Cancer Causes & Control, 2011, 22, 9, 1333
- You have free access to this content14, , What about supplements for osteoarthritis? A critical and evidenced-based review, International Journal of Rheumatic Diseases, 2011, 14, 2Direct Link:
- 15
- 16
- 17, , , , , Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees, Arthritis & Rheumatism, 2010, 62, 5Direct Link:
- 18, , , , Glucosamine sulfate for knee osteoarthritis: science and evidence-based use, Therapy, 2010, 7, 6, 591
- 19, , , , , , , , Glucosamine sulphate in the treatment of knee osteoarthritis: cost-effectiveness comparison with paracetamol, International Journal of Clinical Practice, 2010, 64, 6Direct Link:
- 20, , , , , , , , , , , , , , , , OARSI recommendations for the management of hip and knee osteoarthritis, Osteoarthritis and Cartilage, 2010, 18, 4, 476
- 21
- 22, , , A Review of Evidence-Based Medicine for Glucosamine and Chondroitin Sulfate Use in Knee Osteoarthritis, Arthroscopy: The Journal of Arthroscopic & Related Surgery, 2009, 25, 1, 86
- 23, , , , , Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis, Advances in Therapy, 2009, 26, 9, 858
- 24, , , , , , , , , , Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial, Osteoarthritis and Cartilage, 2009, 17, 4, 427
- 25, , , , , Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study, Clinical Rheumatology, 2009, 28, 8, 907
- 26, , , , , , , , , Glucosamine Binding to Proteins in Plasma and Synovial Fluid and Blood Cell/Plasma Partitioning in Mouse and Man in Vitro, Drug Metabolism and Drug Interactions, 2009, 24, 2-4, 211
- 27, Glucosamine therapy for knee osteoarthritis: pharmacokinetic considerations, Expert Review of Clinical Pharmacology, 2009, 2, 4, 359
- 28, , , , , , , In Vitro Study of the Inhibition and Induction of Human Cytochromes P450 by Crystalline Glucosamine Sulfate, Drug Metabolism and Drug Interactions, 2009, 24, 2-4, 195
- 29, , Nutritional Supplementation for Osteoarthritis, Alternative and Complementary Therapies, 2009, 15, 4, 173
- 30, , , , , , The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled trial, Current Therapeutic Research, 2009, 70, 3, 185
- 31, , , , , , , , , , , , , , , , , , Traduction française des recommandations de lâOsteoarthritis Research Society International (OARSI) sur la prise en charge de la gonarthrose et de la coxarthrose, Revue du Rhumatisme, 2009, 76, 3, 279
- 32, , , , , , , , Additive effects of glucosamine or risedronate for the treatment of osteoarthritis of the knee combined with home exercise: a prospective randomized 18-month trial, Journal of Bone and Mineral Metabolism, 2008, 26, 3, 279
- 33, , , , , , , Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model, Clinical Rheumatology, 2008, 28, 2, 109
- 34, , , , , , , Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride, Osteoarthritis and Cartilage, 2008, 16, 9, 973
- 35, , , , Conceptual Development of a Measure to Assess Pharmacists' Knowledge of Herbal and Dietary Supplements, American Journal of Pharmaceutical Education, 2008, 72, 3, 59
- 36, , Dietary and Viscosupplementation in Ankle Arthritis, Foot and Ankle Clinics of North America, 2008, 13, 3, 353
- 37, , , , Does oral glucosamine prevent subchondral bone loss in an animal model of osteoarthritis? Comment on the article by Wang et al, Arthritis & Rheumatism, 2008, 58, 2Direct Link:
- 38, , Drug Insight: aggrecanases as therapeutic targets for osteoarthritis, Nature Clinical Practice Rheumatology, 2008, 4, 8, 420
- 39, , Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes, Pflügers Archiv - European Journal of Physiology, 2008, 456, 3, 501
- 40, Glucosamine and chondroitin sulfate provide some symptom- and structure-modifying effects in patients with osteoarthritis, Drugs & Therapy Perspectives, 2008, 24, 3, 18
- 41, , , Glucosamine Sulfate and Chondroitin Sulfate for the Treatment of Osteoarthritis, The Journal of the Korean Rheumatism Association, 2008, 15, 3, 197
- 42, , , , , , , , , , , , , , , , OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines, Osteoarthritis and Cartilage, 2008, 16, 2, 137
- 43, , , The Post-NSAID Era: What to use now for the pharmacologic treatment of pain and inflammation in osteoarthritis, Current Rheumatology Reports, 2008, 10, 1, 49
- 44, Tratamiento de la artrosis en Atención Primaria: revisión de los fármacos de acción sintomática lenta (SYSADOA), SEMERGEN - Medicina de Familia, 2008, 34, 8, 400
- 45, Whatʼs a Clinician to Think? Whatʼs a Clinician to Do?, Southern Medical Journal, 2008, 101, 3, 222
- 46, , Glucosamine and Chondroitin Sulfate as Therapeutic Agents for Knee and Hip Osteoarthritis, Drugs & Aging, 2007, 24, 7, 573
- 47
- 48, , , , , , , , , , , , , , , , OARSI recommendations for the management of hip and knee osteoarthritis, Part I: Critical appraisal of existing treatment guidelines and systematic review of current research evidence, Osteoarthritis and Cartilage, 2007, 15, 9, 981
- 49, Prescription of glucosamine for osteoarthritis: does it work and is it safe?, Nature Clinical Practice Rheumatology, 2007, 3, 7, 364
- 50, , , , , , , , Synovial and plasma glucosamine concentrations in osteoarthritic patients following oral crystalline glucosamine sulphate at therapeutic dose, Osteoarthritis and Cartilage, 2007, 15, 7, 764
- 51, The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest, Arthritis & Rheumatism, 2007, 56, 7Direct Link:
- 52, , , The post-NSAID era: What to use now for the pharmacologic treatment of pain and inflammation in osteoarthritis, Current Pain and Headache Reports, 2007, 11, 6, 415
- 53, , , , , , , , Glucosamine therapy for treating osteoarthritis, The Cochrane Library,Direct Link:

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