Research Article

You have full text access to this OnlineOpen article

Arthritic pain is processed in brain areas concerned with emotions and fear

  1. B. Kulkarni1,*,
  2. D. E. Bentley1,
  3. R. Elliott2,
  4. P. J. Julyan3,
  5. E. Boger1,
  6. A. Watson1,
  7. Y. Boyle1,
  8. W. El-Deredy1,
  9. A. K. P. Jones1

Article first published online: 28 MAR 2007

DOI: 10.1002/art.22460

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 56, Issue 4, pages 1345–1354, April 2007

Additional Information

How to Cite

Kulkarni, B., Bentley, D. E., Elliott, R., Julyan, P. J., Boger, E., Watson, A., Boyle, Y., El-Deredy, W. and Jones, A. K. P. (2007), Arthritic pain is processed in brain areas concerned with emotions and fear. Arthritis & Rheumatism, 56: 1345–1354. doi: 10.1002/art.22460

Author Information

  1. 1

    University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford, UK

  2. 2

    University of Manchester, Manchester, UK

  3. 3

    Christie Hospital National Health Service Trust, Withington, Manchester, UK

*Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Eccles Old Road, Salford M6 8HD, UK

Publication History

  1. Issue published online: 28 MAR 2007
  2. Article first published online: 28 MAR 2007
  3. Manuscript Accepted: 19 DEC 2006
  4. Manuscript Received: 23 NOV 2006

Funded by

  • Arthritis Research Campaign, UK

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (410K)

REFERENCES

  • 1
    Bowsher D. Termination of the central pain pathway in man: the conscious appreciation of pain. Brain 1957; 80: 606–22.
  • 2
    Jones AK, Kulkarni B, Derbyshire SW. Pain mechanisms and their disorders [review]. Br Med Bull 2003; 65: 83–93.
  • 3
    Peyron R, Laurent B, Garcia-Larrea L. Functional imaging of brain responses to pain: a review and meta-analysis [review]. Neurophysiol Clin 2000; 30: 263–88.
  • 4
    Melzack R, Casey KL. Sensory, motivational and central control determinants of pain: a new conceptual model. In: KenshaloDR, editor. The skin senses. Springfield (IL): Charles C. Thomas; 1968. p. 423–43.
  • 5
    Vogt BA. Pain and emotion interactions in subregions of the cingulate gyrus [review]. Nat Rev Neurosci 2005; 6: 533–44.
  • 6
    Craig AD. Pain mechanisms: labeled lines versus convergence in central processing [review]. Annu Rev Neurosci 2003; 26: 1–30.
  • 7
    Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science 1997; 277: 968–71.
  • 8
    Tolle TR, Kaufmann T, Siessmeier T, Lautenbacher S, Berthele A, Munz F, et al. Region-specific encoding of sensory and affective components of pain in the human brain: a positron emission tomography correlation analysis. Ann Neurol 1999; 45: 40–7.
    Direct Link:
  • 9
    Giesecke T, Gracely RH, Grant MA, Nachemson A, Petzke F, Williams DA, et al. Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum 2004; 50: 613–23.
    Direct Link:
  • 10
    Derbyshire SW, Jones AK, Creed F, Starz T, Meltzer CC, Townsend DW, et al. Cerebral responses to noxious thermal stimulation in chronic low back pain patients and normal controls. Neuroimage 2002; 16: 158–68.
  • 11
    Derbyshire SW, Jones AK, Devani P, Friston KJ, Feinmann C, Harris M, et al. Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography. J Neurol Neurosurg Psychiatry 1994; 57: 1166–72.
  • 12
    Jones AK, Derbyshire SW. Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Ann Rheum Dis 1997; 56: 601–7.
  • 13
    Phelps ME. Positron computed tomography studies of cerebral glucose metabolism in man: theory and application in nuclear medicine. Semin Nucl Med 1981; 11: 32–49.
  • 14
    Ginsberg MD, Chang JY, Kelley RE, Yoshii F, Barker WW, Ingenito G, et al. Increases in both cerebral glucose utilization and blood flow during execution of a somatosensory task. Ann Neurol 1988; 23: 152–60.
    Direct Link:
  • 15
    Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29: 1039–49.
    Direct Link:
  • 16
    Fruhstorfer H, Lindblom U, Schmidt WC. Method for quantitative estimation of thermal thresholds in patients. J Neurol Neurosurg Psychiatry 1976; 39: 1071–5.
  • 17
    Zigmond AS, Snaith RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983; 67: 361–70.
    Direct Link:
  • 18
    Radloff LS. The CES-D Scale: a self report depression scale for research in the general population. Appl Psychol Meas 1977; 1: 385–401.
  • 19
    Spielberger CD. Assessment of state and trait anxiety. South Psychologist 1985; 1: 6–16.
  • 20
    Sullivan M, Bishop S, Pivik J. The Pain Catastrophizing Scale: development and validation. Psychol Assess 1995; 7: 524–32.
  • 21
    Gispert JD, Pascau J, Reig S, Martinez-Lazaro R, Molina V, Garcia-Barreno P, et al. Influence of the normalization template on the outcome of statistical parametric mapping of PET scans. Neuroimage 2003; 19: 601–12.
  • 22
    Gispert JD, Pascau J, Reig S, Garcia-Barreno P, Desco M. Statistical parametric mapping (SPM) in nuclear medicine. Rev Esp Med Nucl 2003; 22: 43–53. In Spanish.
  • 23
    Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Georg Thieme Verlag; 1998.
  • 24
    Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 1999; 156: 675–82.
  • 25
    Kulkarni B, Bentley DE, Elliott R, Youell P, Watson A, Derbyshire SW, et al. Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems. Eur J Neurosci 2005; 21: 3133–42.
    Direct Link:
  • 26
    Mayberg HS. Modulating limbic-cortical circuits in depression: targets of antidepressant treatments [review]. Semin Clin Neuropsychiatry 2002; 7: 255–68.
  • 27
    Bentley DE, Derbyshire SW, Youell PD, Jones AK. Caudal cingulate cortex involvement in pain processing: an inter-individual laser evoked potential source localisation study using realistic head models. Pain 2003; 102: 265–71.
  • 28
    Maddock RJ, Garrett AS, Buonocore MH. Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience 2001; 104: 667–76.
  • 29
    Maddock RJ, Garrett AS, Buonocore MH. Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Hum Brain Mapp 2003; 18: 30–41.
    Direct Link:
  • 30
    Hsieh JC, Belfrage M, Stone-Elander S, Hansson P, Ingvar M. Central representation of chronic ongoing neuropathic pain studied by positron emission tomography. Pain 1995; 63: 225–36.
  • 31
    Maddock RJ. The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain [review]. Trends Neurosci 1999; 22: 310–6.
  • 32
    Bohus B, Koolhaas JM, Luiten PG, Korte SM, Roozendaal B, Wiersma A. The neurobiology of the central nucleus of the amygdala in relation to neuroendocrine and autonomic outflow. Prog Brain Res 1996; 107: 447–60.
  • 33
    Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C, Buchel C. Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain 2002; 125(Pt 6): 1326–36.
  • 34
    Buchel C, Dolan RJ, Armony JL, Friston KJ. Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci 1999; 19: 10869–76.
  • 35
    Chudler EH, Dong WK. The role of the basal ganglia in nociception and pain [review]. Pain 1995; 60: 3–38.
  • 36
    Anderson AK, Phelps EA. Lesions of the human amygdala impair enhanced perception of emotionally salient events. Nature 2001; 411: 305–9.
  • 37
    Petrovic P, Carlsson K, Petersson KM, Hansson P, Ingvar M. Context-dependent deactivation of the amygdala during pain. J Cogn Neurosci 2004; 16: 1289–301.
  • 38
    Kupfermann I. Localisation of higher cognitive and affective functions: the association cortices. In: KandelER, SchwartzJH, JessellTM, editors. Principles of neural science. Amsterdam: Elsevier; 1991. p. 823–38.
  • 39
    Posner MI, Petersen SE. The attention system of the human brain [review]. Annu Rev Neurosci 1990; 13: 25–42.
  • 40
    Lorenz J, Minoshima S, Casey KL. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 2003; 126(Pt 5): 1079–91.
  • 41
    Jones AK, Watabe H, Cunningham VJ, Jones T. Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by 11C diprenorphine binding in PET. Eur J Pain 2004; 8: 479–85.
  • 42
    Jones A, Pike V, Luthra S, Turton D, Brady F, Jones T, et al. 11C-diprenorphine and 11C-meptazinol: new specific and non-specific probes for studying opioid binding sites using positron tomography. J Cereb Blood Flow Metab 1985; 5(S1): 603–4.
  • 43
    Jones AK, Qi LY, Fujirawa T, Luthra SK, Ashburner J, Bloomfield P, et al. In vivo distribution of opioid receptors in man in relation to the cortical projections of the medial and lateral pain systems measured with positron emission tomography. Neurosci Lett 1991; 126: 25–8.
  • 44
    Jones AK, Cunningham VJ, Ha-Kawa S, Fujiwara T, Luthra SK, Silva S, et al. Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. Br J Rheumatol 1994; 33: 909–16.
  • 45
    Jones AK, Kitchen ND, Watabe H, Cunningham VJ, Jones T, Luthra SK, et al. Measurement of changes in opioid receptor binding in vivo during trigeminal neuralgic pain using 11C diprenorphine and positron emission tomography. J Cereb Blood Flow Metab 1999; 19: 803–8.
  • 46
    Le Guen S, Mas NM, Canestrelli C, Chen H, Fournie-Zaluski MC, Cupo A, et al. Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone. Pain 2003; 104: 139–48.
  • 47
    Hippisley-Cox J, Coupland C. Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ 2005; 330: 1366.
  • 48
    Derbyshire SW, Jones AK. Cerebral responses to a continual tonic pain stimulus measured using positron emission tomography. Pain 1998; 76: 127–35.
View Full Article (HTML) Get PDF (410K)