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Dr. Weinblatt has received consulting fees and/or honoraria (less than $10,000) from Millennium Pharmaceuticals.
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Original Article
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Agreement between patient report and medical record review for medications used for rheumatoid arthritis: The accuracy of self-reported medication information in patient registries
Article first published online: 28 FEB 2007
DOI: 10.1002/art.22549
Copyright © 2007 by the American College of Rheumatology
Additional Information
How to Cite
Solomon, D. H., Stedman, M., Licari, A., Weinblatt, M. E., Maher, N. and shadick, N. (2007), Agreement between patient report and medical record review for medications used for rheumatoid arthritis: The accuracy of self-reported medication information in patient registries. Arthritis & Rheumatism, 57: 234–239. doi: 10.1002/art.22549
Publication History
- Issue published online: 28 FEB 2007
- Article first published online: 28 FEB 2007
- Manuscript Accepted: 21 JUN 2006
- Manuscript Received: 11 JAN 2006
Funded by
- Millennium Pharmaceuticals
- Abstract
- Article
- References
- Cited By
Keywords:
- Rheumatoid arthritis;
- Medication use;
- Interobserver agreement;
- Patient registry;
- Self-report;
- Medical record
Abstract
Objective
With the growth in patient registries in rheumatic disease research, it is important to validate the collected information. We examined the convergent validity of self-reported medication use for rheumatoid arthritis (RA).
Methods
In the setting of the Brigham Rheumatoid Arthritis Sequential Study (BRASS), a large registry of patients with RA, we examined the agreement between patients' self-report of current and past RA medication use and information from medical records. For a sample of patients in BRASS, these 2 sources of information were compared using the kappa statistic as well as the percent agreement.
Results
The 91 patients selected for assessment were typical of a prevalent RA cohort: >80% were women and the mean disease duration was 16 years. The agreement for current medication use was excellent, ranging from 0.71 for sulfasalazine to 0.96 for methotrexate. However, for past medication use agreement was lower, ranging from 0.13 for methotrexate to 0.74 for aurothioglucose. The weighted kappa for cumulative oral glucocorticoid dose was 0.67.
Conclusion
Self-report of current medication use and cumulative oral glucocorticoid dose appears to have moderate to excellent validity. However, self-report of past medication use may not be valid.