Dr. Choi has received compensation (less than $10,000 each) for serving on the advisory boards of TAP and Savient Pharmaceuticals.
Coffee consumption and risk of incident gout in men: A prospective study
Article first published online: 25 MAY 2007
Copyright © 2007 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 56, Issue 6, pages 2049–2055, June 2007
How to Cite
Choi, H. K., Willett, W. and Curhan, G. (2007), Coffee consumption and risk of incident gout in men: A prospective study. Arthritis & Rheumatism, 56: 2049–2055. doi: 10.1002/art.22712
- Issue published online: 25 MAY 2007
- Article first published online: 25 MAY 2007
- Manuscript Accepted: 7 MAR 2007
- Manuscript Received: 28 DEC 2006
- NIH. Grant Numbers: DK-58573, AA-11181, HL-35464, CA-55075
- TAP Pharmaceuticals
Coffee is one of the most widely consumed beverages in the world and may affect the risk of gout via various mechanisms. We prospectively evaluated the relationship between coffee intake and the risk of incident gout in a large cohort of men.
Over a 12-year period, we studied 45,869 men with no history of gout at baseline. Intake of coffee, decaffeinated coffee, tea, and total caffeine was assessed every 4 years through validated questionnaires. We used a supplementary questionnaire to ascertain whether participants met the American College of Rheumatology survey criteria for gout.
We documented 757 confirmed incident cases of gout. Increasing coffee intake was inversely associated with the risk of gout. The multivariate relative risks (RRs) for incident gout according to coffee consumption categories (0, <1, 1–3, 4–5, and ≥6 cups per day) were 1.00, 0.97, 0.92, 0.60 (95% confidence interval [95% CI] 0.41–0.87), and 0.41 (95% CI 0.19–0.88), respectively (P for trend = 0.009). For decaffeinated coffee, the multivariate RRs according to consumption categories (0, <1, 1–3, and ≥4 cups per day) were 1.00, 0.83, 0.67 (95% CI 0.54–0.82), and 0.73 (95% CI 0.46–1.17), respectively (P for trend = 0.002). Total caffeine from all sources and tea intake were not associated with the risk of gout.
These prospective data suggest that long-term coffee consumption is associated with a lower risk of incident gout.