• 1
    Arthritis Research Campaign. Arthritis: the big picture. Chesterfield (UK): ARC; 2004. URL:
  • 2
    World Health Organization. The burden of musculoskeletal conditions at the start of the new millennium: report of a WHO Scientific Group, Technical Report Series No 919. Geneva: WHO; 2003. URL:
  • 3
    Bierma-Zeinstra SM, Lipschart S, Njoo KH, Bernsen R, Verhaar J, Prins A, et al. How do general practitioners manage hip problems in adults? Scand J Prim Health Care 2000; 18: 15964.
  • 4
    Mantyselka P, Kumposalo E, Ahonen R, Kumposalo A, Kauhanen J, Viinimaki H, et al. Pain as a reason to visit the doctor: a study in Finnish primary health care. Pain 2001; 89: 17580.
  • 5
    Morgan B, Mullick S, Harper WM, Finlay DB. An audit of knee radiographs performed for general practitioners. Br J Radiol 1997; 70: 25660.
  • 6
    Linsell L, Dawson J, Zondervan K, Rose P, Carr A, Randall T, et al. Population survey comparing older adults with hip versus knee pain in primary care. Br J Gen Pract 2005; 55: 1928.
  • 7
    The Royal College of Radiologists. Making the best use of a department of radiography: guidelines for doctors. 5th ed. London: The Royal College of Radiologists; 2003.
  • 8
    Creamer P. Current perspectives on the clinical presentation of joint pain in human OA. In: ChadwickDJ, GoodeJ, editors. Osteoarthritic joint pain. Chichester (UK): John Wiley & Sons; 2004. p. 6478.
  • 9
    Eccles M, Steen N, Grimshaw J, Thomas L, McNamee P, Soutter J, et al. Effect of audit and feedback, and reminder messages on primary-care radiology referrals: a randomised trial. Lancet 2001; 357: 14069.
  • 10
    Ramsay CR, Eccles M, Grimshaw JM, Steen N. Assessing the long-term effect of educational reminder messages on primary care radiology referrals. Clin Radiol 2003; 58: 31921.
  • 11
    Laupacis A, Sekar N, Stiell IG. Clinical prediction rules: a review and suggested modifications to methodological standards. JAMA 1997; 277: 48894.
  • 12
    Thomas E, Wilkie R, Peat G, Hill S, Dziedzic K, Croft P. The North Staffordshire Osteoarthritis Project: NorStOP. Prospective, 3-year study of the epidemiology and management of clinical osteoarthritis in a general population of older adults. BMC Musculoskelet Dis URL:
  • 13
    Peat G, Thomas E, Handy J, Wood L, Dziedzic K, Myers H, et al. The Knee Clinical Assessment Study, CAS(K): a prospective study of knee pain and knee osteoarthritis in the general population. BMC Musculoskelet Disord URL:
  • 14
    Peat G, Lawton H, Hay E, Greig J, Thomas E, for the KNE-SCI Study Group. Development of the Knee Standardized Clinical Interview: a research tool for studying the primary care clinical epidemiology of knee problems in older adults. Rheumatology (Oxford) 2002; 41: 11018.
  • 15
    Wood LR. The physical examination of older people with knee pain: a study of reliability and relationship to self-reported function in primary care [dissertation]. Keele (UK): Keele University; 2004.
  • 16
    Peat G, Wood L, Wilkie R, Thomas E, for the KNE-SCI Study Group. How reliable is structured clinical history-taking in older adults with knee problems? Inter- and intraobserver variability of the KNE-SCI. J Clin Epidemiol 2003; 56: 10307.
  • 17
    Wood L, Peat G, Wilkie R, Hay E, Thomas E, Sim J. Reliability of physical examination of the knee in older adults with knee problems. J Clin Epidemiol 2006; 59: 51220.
  • 18
    Buckland-Wright JC, Wolfe F, Ward RJ, Flowers N, Hayne C. Substantial superiority of semiflexed (MTP) views in knee osteoarthritis: a comparative radiographic study, without fluoroscopy, of standing extended, semiflexed (MTP), and Schuss views. J Rheumatol 1999; 26: 266474.
  • 19
    McAlindon TE, Snow S, Cooper C, Dieppe PA. Radiographic patterns of osteoarthritis of the knee joint in the community: the importance of the patellofemoral joint. Ann Rheum Dis 1992; 51: 8449.
  • 20
    Altman RD, Hochberg M, Murphy WA Jr, Wolfe F, Lesquesne M. Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage 1995; 3 Suppl A: 370.
  • 21
    Altman RD, Fries JF, Bloch DA, Carstens J, Cooke TD, Genant H, et al. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum 1987; 30: 121425.
  • 22
    Burnett S, Hart D, Cooper C, Spector T. A radiographic atlas of osteoarthritis. London: Springer-Verlag; 1994.
  • 23
    Lawrence JS. Rheumatism in populations. London: WM Heinemann Medical Books; 1977.
  • 24
    Duncan RC, Hay EM, Saklatvala J, Croft PR. Prevalence of radiographic osteoarthritis: it all depends on your point of view. Rheumatology (Oxford) 2006; 45: 75760.
  • 25
    Spector TD, Hart DJ, Byrne J, Harris PA, Dacre JE, Doyle DV. Definition of osteoarthritis of the knee for epidemiological studies. Ann Rheum Dis 1993; 52: 7904.
  • 26
    Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmick CG, Jordan JM, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 2000; 133: 63546.
  • 27
    Doherty M. Risk factors for progression of knee osteoarthritis [letter]. Lancet 2001; 358: 7756.
  • 28
    Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Special article: development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29: 103949.
  • 29
    Claessens AA, Schouten JS, van den Ouweland FA, Valkenburg HA. Do clinical findings associate with radiographic osteoarthritis of the knee? Ann Rheum Dis 1990; 49: 7714.
  • 30
    Bagge E, Bjelle A, Eden S, Svanborg A. Osteoarthritis in the elderly: clinical and radiological findings in 79 and 85 year olds. Ann Rheum Dis 1991; 50: 5359.
  • 31
    Bijl D, Dekker J, van Baar ME, Oostendorp RA, Lemmens AM, Bijlsma JW, et al. Validity of Cyriax's concept capsular pattern for the diagnosis of osteoarthritis of hip and/or knee. Scand J Rheumatol 1998; 27: 34751.
  • 32
    Klippel JH, Dieppe PA, Ferri FF. Primary care rheumatology. London: Mosby; 1999.
  • 33
    LaValley M, McAlindon TE, Evans S, Chaisson CE, Felson DT. Problems in the development and validation of questionnaire-based screening instruments for ascertaining cases with symptomatic knee osteoarthritis: the Framingham Study. Arthritis Rheum 2001; 44: 110513.
  • 34
    WONCA International Classification Committee. ICPC-2 International Classification of Primary Care. 2nd ed. Oxford: Oxford University Press; 1998.
  • 35
    Primary Care Rheumatology Society. Knee osteoarthritis: management options. Northallerton (UK): Primary Care Rheumatology Society; 1999.
  • 36
    Ersoz M, Ergun S. Relationship between knee range of motion and Kellgren-Lawrence radiographic scores in knee osteoarthritis. Am J Phys Med Rehabil 2003; 82: 1105.
  • 37
    Angst F, Ewert T, Lehmann S, Aeschlimann A, Stucki G. The factor subdimensions of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) help to specify hip and knee osteoarthritis: a prospective evaluation and validation study. J Rheumatol 2005; 32: 132430.
  • 38
    Creamer P, Hochberg MC. Why does osteoarthritis of the knee hurt: sometimes? Br J Rheumatol 1997; 36: 7268.
  • 39
    Brandt KD, Heilman DK, Slemenda C, Katz BP, Mazzuca S, Braunstein EM, et al. A comparison of lower extremity muscle strength, obesity, and depression scores in elderly subjects with knee pain with and without radiographic evidence of knee osteoarthritis. J Rheumatol 2000; 27: 193746.
  • 40
    Birrell F, Croft P, Cooper C, Hosie G, Macfarlane G, Silman A, and the PCR Hip Study Group. Predicting radiographic hip osteoarthritis from range of movement. Rheumatology (Oxford) 2001; 40: 50612.
  • 41
    Hosmer DW, Lemeshow S. Applied logistic regression. 2nd ed. New York: John Wiley & Sons; 2000.
  • 42
    Steyerberg EW, Harrell FE Jr, Borsboom GJ, Eijkemans MJ, Vergouwe Y, Habbema JD. Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol 2001; 54: 77481.
  • 43
    Moons KG, Harrell FE, Steyerberg EW. Should scoring rules be based on odds ratios or regression coefficients? [letter]. J Clin Epidemiol 2002; 55: 10545.
  • 44
    Ware J Jr, Kosinski M, Keller SD. A 12-item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34: 22033.
  • 45
    Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 36170.
  • 46
    Bellamy N. WOMAC osteoarthritis index. A user's guide. Ontario: London Health Services Centre, McMaster University; 1996.
  • 47
    Efron B. The jacknife, the bootstrap and other resampling plans. Philadelphia: Society for Industrial and Applied Mathematics; 1982.
  • 48
    Moons KG, Biesheuvel CJ, Grobbee DE. Test research versus diagnostic research. Clin Chem 2004; 50: 4736.
  • 49
    Miettinen OS. Theoretical epidemiology: principles of occurrence research in medicine. New York: John Wiley & Sons; 1985.
  • 50
    Moons KG, Grobbee DE. Diagnostic studies as multivariable, prediction research [letter]. J Epidemiol Community Health 2002; 56: 3378.
  • 51
    Bierma-Zeinstra SM, Oster JD, Bernsen RM, Verhaar JA, Ginai AZ, Bohnen AM. Joint space narrowing and relationship with symptoms and signs in adults consulting for hip pain in primary care. J Rheumatol 2002; 29: 17138.
  • 52
    Jinks C, Jordan K, Ong BN, Croft P. A brief screening tool for knee pain in primary care (KNEST). 2. Results from a survey in the general population aged 50 and over. Rheumatology (Oxford) 2004; 43: 5561.
  • 53
    Cooper C, McAlindon T, Snow S, Vines K, Young P, Kirwan J, et al. Mechanical and constitutional risk factors for symptomatic knee osteoarthritis: differences between medial tibiofemoral and patellofemoral disease. J Rheumatol 1994; 21: 30713.
  • 54
    McAlindon T, Zhang Y, Hannan M, Naimark A, Weissman B, Castelli W, et al. Are risk factors for patellofemoral and tibiofemoral knee osteoarthritis different? J Rheumatol 1996; 23: 3327.
  • 55
    Cicuttini FM, Spector T, Baker J. Risk factors for osteoarthritis in the tibiofemoral and patellofemoral joints of the knee. J Rheumatol 1997; 24: 11647.
  • 56
    Baker KR, Xu L, Zhang Y, Nevitt M, Niu J, Aliabadi P, et al. Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing Osteoarthritis Study. Arthritis Rheum 2004; 50: 181521.
  • 57
    Kannel WB, D'Agostino RB, Sullivan L, Wilson PW. Concept and usefulness of cardiovascular risk profile. Am Heart J 2004; 148: 1626.
  • 58
    Lacey RJ, Lewis M, Jordan K, Jinks C, Sim J. Interrater reliability of scoring of pain drawings in a self-report health survey. Spine 2005; 30: E4558.
  • 59
    Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain. Pain 1992; 50: 13349.