SEARCH

SEARCH BY CITATION

REFERENCES

  • 1
    Buckwalter JA, Saltzman C, Brown T. The impact of osteoarthritis: implications for research. Clin Orthop Relat Res 2004;(427 Suppl ): S615.
  • 2
    Bobinac D, Spanjol J, Zoricic S, Maric I. Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone 2003; 32: 28490.
  • 3
    Yager TD, Dempsey AA, Tang H, Stamatiou D, Chao S, Marshall KW, et al. First comprehensive mapping of cartilage transcripts to the human genome. Genomics 2004; 84: 52435.
  • 4
    Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A 2004; 101: 975762.
  • 5
    Malemud CJ. Protein kinases in chondrocyte signaling and osteoarthritis. Clin Orthop Relat Res 2004;(427 Suppl ): S14551.
  • 6
    Rountree RB, Schoor M, Chen H, Marks ME, Harley V, Mishina Y, et al. BMP receptor signaling is required for postnatal maintenance of articular cartilage. PLoS Biol 2004; 2: e355.
  • 7
    Southam L, Dowling B, Ferreira A, Marcelline L, Mustafa Z, Chapman K, et al. Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3–q13. Arthritis Rheum 2004; 50: 39104.
  • 8
    Wang X, Manner PA, Horner A, Shum L, Tuan RS, Nuckolls GH. Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage. Osteoarthritis Cartilage 2004; 12: 96373.
  • 9
    Hayami T, Pickarski M, Wesolowski GA, Mclane J, Bone A, Destefano J, et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum 2004; 50: 1193206.
  • 10
    Iannone F, Lapadula G. The pathophysiology of osteoarthritis. Aging Clin Exp Res 2003; 15: 36472.
  • 11
    Martel-Pelletier J, Di Battista JA, Lajeunesse D, Pelletier JP. IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis. Inflamm Res 1998; 47: 90100.
  • 12
    Aspden RM, Scheven BA, Hutchison JD. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism. Lancet 2001; 357: 111820.
  • 13
    Madsen OR, Brot C, Petersen MM, Sorensen OH. Body composition and muscle strength in women scheduled for a knee or hip replacement: a comparative study of two groups of osteoarthritic women. Clin Rheumatol 1997; 16: 3944.
  • 14
    Hurley MV. The role of muscle weakness in the pathogenesis of osteoarthritis. Rheum Dis Clin North Am 1999; 25: 28398, vi.
  • 15
    Anderson-MacKenzie JM, Billingham ME, Bailey AJ. Collagen remodeling in the anterior cruciate ligament associated with developing spontaneous murine osteoarthritis. Biochem Biophys Res Commun 1999; 258: 7637.
  • 16
    Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 1437.
  • 17
    Kobayashi T, Notoya K, Naito T, Unno S, Nakamura A, Martel-Pelletier J, et al. Pioglitazone, a peroxisome proliferator–activated receptor γ agonist, reduces the progression of experimental osteoarthritis in guinea pigs. Arthritis Rheum 2005; 52: 47987.
  • 18
    Cuzzocrea S, Mazzon E, Dugo L, Patel NS, Serraino I, Di Paola R, et al. Reduction in the evolution of murine type II collagen– induced arthritis by treatment with rosiglitazone, a ligand of the peroxisome proliferator–activated receptor γ. Arthritis Rheum 2003; 48: 354456.
  • 19
    Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA. Peroxisome proliferator-activated receptor (PPAR) γ: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 1994; 135: 798800.
  • 20
    Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor [published erratum appears in Cell 1995;80:following 957]. Cell 1994; 79: 114756.
  • 21
    Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 1998; 391: 7982.
  • 22
    Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte inflammatory cytokines. Nature 1998; 391: 826.
  • 23
    Fahmi H, Di Battista JA, Pelletier JP, Mineau F, Ranger P, Martel-Pelletier J. Peroxisome proliferator–activated receptor γ activators inhibit interleukin-1–induced nitric oxide and matrix metalloproteinase 13 production in human chondrocytes. Arthritis Rheum 2001; 44: 595607.
  • 24
    Fahmi H, Pelletier JP, Di Battista JA, Cheung HS, Fernandes JC, Martel-Pelletier J. Peroxisome proliferator-activated receptor γ activators inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the activator protein 1. Osteoarthritis Cartilage 2002; 10: 1008.
  • 25
    Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT. The STR/ort mouse and its use as a model of osteoarthritis. Osteoarthritis Cartilage 2001; 9: 8591.
  • 26
    Wenz W, Breusch SJ, Graf J, Stratmann U. Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy. J Orthop Res 2000; 18: 60412.
  • 27
    Little C, Smith S, Ghosh P, Bellenger C. Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep. J Rheumatol 1997; 24: 2199209.
  • 28
    Cake MA, Read RA, Guillou B, Ghosh P. Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU). Osteoarthritis Cartilage 2000; 8: 40411.
  • 29
    Hayami T, Pickarski M, Zhuo Y, Wesolowski GA, Rodan GA, Duong LT. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone 2006; 38: 23443.
  • 30
    Hughes TR, Mao M, Jones AR, Burchard J, Marton MJ, Shannon KW, et al. Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nat Biotechnol 2001; 19: 3427.
  • 31
    Marton MJ, DeRisi JL, Bennett HA, Iver VR, Meyer MR, Roberts CJ, et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat Med 1998; 4: 1293301.
  • 32
    Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, et al. A network-based analysis of systemic inflammation in humans [published erratum appears in Nature 2005;438:696]. Nature 2005; 437: 10327.
  • 33
    Okazaki K, Jingushi S, Ikenoue T, Urabe K, Sakai H, Ohtsuru A, et al. Expression of insulin-like growth factor I messenger ribonucleic acid in developing osteophytes in murine experimental osteoarthritis and in rats inoculated with growth hormone-secreting tumor. Endocrinology 1999; 140: 482130.
  • 34
    Kasamatsu A, Endo Y, Uzawa K, Nakashima D, Koike H, Hashitani S, et al. Identification of candidate genes associated with salivary adenoid cystic carcinomas using combined comparative genomic hybridization and oligonucleotide microarray analyses. Int J Biochem Cell Biol 2005; 37: 186980.
  • 35
    Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, et al. Glucocorticoid receptor-dependent gene regulatory networks. PLoS Genet 2005; 1: e16.
  • 36
    Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res 1986; 213: 3440.
  • 37
    Lajeunesse D, Reboul P. Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling. Curr Opin Rheumatol 2003; 15: 62833.
  • 38
    Dieppe P, Cushnaghan J, Young P, Kirwan J. Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 1993; 52: 55763.
  • 39
    Sharif M, George E, Dieppe PA. Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee. Arthritis Rheum 1995; 38: 7881.
  • 40
    Hunter DJ, Spector TD. The role of bone metabolism in osteoarthritis. Curr Rheumatol Rep 2003; 5: 159.
  • 41
    Ameye LG, Young MF. Animal models of osteoarthritis: lessons learned while seeking the “Holy Grail.” Curr Opin Rheumatol 2006; 18: 53747.
  • 42
    Anderson-MacKenzie JM, Quasnichka HL, Starr RL, Lewis EJ, Billingham ME, Bailey AJ. Fundamental subchondral bone changes in spontaneous knee osteoarthritis. Int J Biochem Cell Biol 2005; 37: 22436.
  • 43
    Carlson CS, Loeser RF, Jayo MJ, Weaver DS, Adams MR, Jerome CP. Osteoarthritis in cynomolgus macaques: a primate model of naturally occurring disease. J Orthop Res 1994; 12: 3319.
  • 44
    Ye P, Fang H, Zhou X, He YL, Liu YX. Effect of peroxisome proliferator-activated receptor activators on tumor necrosis factor-α expression in neonatal rat cardiac myocytes. Chin Med Sci J 2004; 19: 2437.
  • 45
    Okamoto H, Iwamoto T, Kotake S, Momohara S, Yamanaka H, Kamatani N. Inhibition of NF-κB signaling by fenofibrate, a peroxisome proliferator-activated receptor-α ligand, presents a therapeutic strategy for rheumatoid arthritis. Clin Exp Rheumatol 2005; 23: 32330.
  • 46
    Diascro DD Jr, Vogel RL, Johnson TE, Witherup KM, Pitzenberger SM, Rutledge SJ, et al. High fatty acid content in rabbit serum is responsible for the differentiation of osteoblasts into adipocyte-like cells. J Bone Miner Res 1998; 13: 96106.
  • 47
    Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL. Differentiation of human marrow stromal precursor cells: bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res 1999; 14: 152235.
  • 48
    Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2005; 13: 98897.
  • 49
    Lajeunesse D. Altered subchondral osteoblast cellular metabolism in osteoarthritis: cytokines, eicosanoids, and growth factors. J Musculoskelet Neuronal Interact 2002; 2: 5046.
  • 50
    Truong LH, Kuliwaba JS, Tsangari H, Fazzalari NL. Differential gene expression of bone anabolic factors and trabecular bone architectural changes in the proximal femoral shaft of primary hip osteoarthritis patients. Arthritis Res Ther 2006; 8: R188.