• 1
    Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001; 60: 917.
  • 2
    Burr D. Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthritis. Osteoarthritis Cartilage 2003; 12: S2030.
  • 3
    Westacott C. Subchondral bone in the pathogenesis of osteoarthritis: biological effects. In: BrandtKD, DohertyM, LohmanderS, editors. Osteoarthritis. 2nd ed. Oxford: Oxford University Press; 2003. p. 13342.
  • 4
    Felson DT, Neogi T. Osteoarthritis: is it a disease of cartilage or of bone? [editorial]. Arthritis Rheum 2004; 50: 3414.
  • 5
    Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 2001; 134: 5419.
  • 6
    Sowers MF, Hayes C, Jamadar D, Capul D, Lachance L, Jannausch M, et al. Magnetic resonance-detected subchondral bone marrow and cartilage defect characteristics associated with pain and X-ray-defined knee osteoarthritis. Osteoarthritis Cartilage 2003; 11: 38793.
  • 7
    Link TM, Steinbach LS, Ghosh S, Ries M, Lu Y, Lane N, et al. Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings. Radiology 2003; 226: 37381.
  • 8
    Kornaat PR, Bloem JL, Ceulemans, RY, Riyazi N, Rosendaal FR, Nelissen RG, et al. Osteoarthritis of the knee: association between clinical features and MR imaging findings. Radiology 2006; 239: 8117.
  • 9
    Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. Obesity and knee osteoarthritis: the Framingham Study. Ann Intern Med 1988; 109: 1824.
  • 10
    Karlson EW, Sanchez-Guerrero J, Wright EA, Lew RA, Daltroy LH, Katz JN, et al. A connective tissue disease screening questionnaire for population studies. Ann Epidemiol 1995; 5: 297302.
  • 11
    RothmanKJ, GreenlandS, editors. Case-control studies. In: Modern epidemiology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 1998. p. 93114.
  • 12
    Radloff LS. The CES-D scale: a self-report depression scale for research in the general population. Appl Psychol Measurement 1977; 1: 385401.
  • 13
    Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988; 15: 183340.
  • 14
    Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 2004; 12: 17790.
  • 15
    Hill CL, Gale DR, Chaisson CE, Skinner K, Kazis L, Gale ME, et al. Periarticular lesions detected on magnetic resonance imaging: prevalence in knees with and without symptoms. Arthritis Rheum 2003; 48: 283644.
  • 16
    Felson DT, McLaughlin S, Goggins J, LaValley MP, Gale ME, Totterman S, et al. Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 2003; 139(5 Pt 1): 3306.
  • 17
    Peterfy CG, Li J, Duryea J, Lynch JA, Miaux Y, Genant HK. Nonfluoroscopic method for flexed radiography of the knee that allows reproducible joint-space width measurement [abstract]. Arthritis Rheum 1998; 41: S361.
  • 18
    Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957; 16: 494501.
  • 19
    Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis [published erratum appears in JAMA 2001;286:792]. JAMA 2001; 286: 18895.
  • 20
    Hill CL, Gale DG, Chaisson CE, Skinner K, Kazis L, Gale ME, et al. Knee effusions, popliteal cysts, and synovial thickening: association with knee pain in osteoarthritis. J Rheumatol 2001; 28: 13307.
  • 21
    Wilson AJ, Murphy WA, Hardy DC, Totty WG. Transient osteoporosis: transient bone marrow edema? Radiology 1988; 167: 75760.
  • 22
    Vande Berg BC, Malghem J, Goffin EJ, Duprez TP, Maldague BE. Transient epiphyseal lesions in renal transplant recipients: presumed insufficiency stress fractures. Radiology 1994; 191: 4037.
  • 23
    Arndt WF, Truax AL, Barnett FM, Simmons GE, Brown DC. MRI diagnosis of bone contusions of the knee: comparison of coronal T2-weighted fast spin-echo with fat saturation and fast spin-echo STIR images with conventional STIR images. AJR Am J Roentgenol 1996; 166: 11924.
  • 24
    Hunter DJ, Zhang Y, Niu J, Tu X, Amin S, Goggins J, et al. Structural factors associated with malalignment in knee osteoarthritis: the Boston Osteoarthritis Knee Study. J Rheumatol 2005; 32: 21929.
  • 25
    Hunter DJ, Zhang Y, Niu J, Goggins J, Amin S, LaValley MP, et al. Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis. Arthritis Rheum 2006; 54: 152935.
  • 26
    Garnero P, Peterfy C, Zaim S, Schoenharting M. Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: a three-month longitudinal study. Arthritis Rheum 2005; 52: 28229.