Initial validation of the pediatric automated neuropsychological assessment metrics for CHILDHOOD-ONSET systemic lupus erythematosus
Version of Record online: 28 SEP 2007
Copyright © 2007 by the American College of Rheumatology
Arthritis Care & Research
Volume 57, Issue 7, pages 1174–1182, 15 October 2007
How to Cite
Brunner, H. I., Ruth, N. M., German, A., Nelson, S., Passo, M. H., Roebuck-Spencer, T., Ying, J. and Ris, D. (2007), Initial validation of the pediatric automated neuropsychological assessment metrics for CHILDHOOD-ONSET systemic lupus erythematosus. Arthritis & Rheumatism, 57: 1174–1182. doi: 10.1002/art.23005
- Issue online: 28 SEP 2007
- Version of Record online: 28 SEP 2007
- Manuscript Accepted: 26 MAR 2007
- Manuscript Received: 5 DEC 2006
- Lupus Foundation of America
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Number: P60-AR-47784
- US Public Health Service. Grant Number: M01-RR-08084
- Cognitive functioning;
- Systemic lupus erythematosus;
- Automated Neuropsychological Assessment Metrics
To evaluate the concurrent validity and diagnostic accuracy of the pediatric Automated Neuropsychological Assessment Metrics (Ped-ANAM) when used in childhood-onset systemic lupus erythematosus (SLE).
Formal neuropsychological testing and the Ped-ANAM were performed on 27 children with SLE who had not been previously diagnosed with neuropsychiatric SLE. Performance when completing the 10 Ped-ANAM tests was based on accuracy (AC), mean time to correct response, coefficient of variation of the time required for a correct response (CVc), and throughput. Formal neuropsychological testing was used as a criterion standard for diagnosing neurocognitive dysfunction (NCD; yes/no).
NCD was common and present in 16 (59%) of 27 participants. Ped-ANAM performance parameters were often moderately correlated with the Z scores on formal neuropsychological testing. The NCD group differed significantly (P < 0.05) from the normal cognition group in 3 Ped-ANAM tests: CVc with mathematical processing (MTH-CVc), AC with continuous performance test (CPT-AC), and CVc with spatial processing (SPD-CVc). Areas under the receiver operating curves (AUCs) ranged between 0.75 and 0.84 when each of these parameters (CPT-AC, MTH-CVc, SPD-CVc) was used to identify NCD independently. The AUC was improved to 0.96 for the combined assessment.
The Ped-ANAM has concurrent validity when used in children with SLE. Initial validation suggests that the Ped-ANAM could be a useful screening tool for NCD in children with SLE.