Dr. Emery is an Arthritis Research Campaign Professor of Rheumatology at Leeds University.
Gout and Pseudogout
Successful treatment of resistant pseudogout with anakinra
Article first published online: 31 JAN 2008
Copyright © 2008 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 58, Issue 2, pages 631–633, February 2008
How to Cite
McGonagle, D., Tan, A. L., Madden, J., Emery, P. and McDermott, M. F. (2008), Successful treatment of resistant pseudogout with anakinra. Arthritis & Rheumatism, 58: 631–633. doi: 10.1002/art.23119
- Issue published online: 31 JAN 2008
- Article first published online: 31 JAN 2008
- Manuscript Accepted: 19 OCT 2007
- Manuscript Received: 14 AUG 2007
We describe herein the case of a 63-year-old man with pseudogout affecting multiple joints that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based on recent data on the molecular mechanism of pseudogout that demonstrated overproduction of interleukin-1 (IL-1), we treated the patient with anakinra, an IL-1 receptor antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers.