Drs. Sebbag and Serre contributed equally to this work.
Rheumatoid Arthritis Basic Science Studies
Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen
Article first published online: 29 FEB 2008
Copyright © 2008 by the American College of Rheumatology
Arthritis & Rheumatism
Volume 58, Issue 3, pages 678–688, March 2008
How to Cite
Clavel, C., Nogueira, L., Laurent, L., Iobagiu, C., Vincent, C., Sebbag, M. and Serre, G. (2008), Induction of macrophage secretion of tumor necrosis factor α through Fcγ receptor IIa engagement by rheumatoid arthritis–specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis & Rheumatism, 58: 678–688. doi: 10.1002/art.23284
- Issue published online: 29 FEB 2008
- Article first published online: 29 FEB 2008
- Manuscript Accepted: 30 NOV 2007
- Manuscript Received: 7 FEB 2007
- Toulouse III University (Université Paul Sabatier
- Association de Recherche sur la Polyarthrite
- Fondation de l'Avenir pour la Recherche Médicale Appliquée
- 3In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum. Clin Exp Immunol 2000; 119: 544–52., , , , , , et al.
- 13Cytokine stimulation of T lymphocytes regulates their capacity to induce monocyte production of tumor necrosis factor-α, but not interleukin-10: possible relevance to pathophysiology of rheumatoid arthritis. Eur J Immunol 1997; 27: 624–32., , , .
- 24Surface-bound anti–type II collagen–containing immune complexes induce production of tumor necrosis factor α, interleukin-1β, and interleukin-8 from peripheral blood monocytes via Fcγ receptor IIa: a potential pathophysiologic mechanism for humoral anti–type II collagen immunity in arthritis. Arthritis Rheum 2006; 54: 1759–71., , , .
- 25Increased expression of Fcγ receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor α and matrix metalloproteinase. Arthritis Rheum 2003; 48: 1002–14., , , , , , et al.
- 42The functional variant of the inhibitory Fcγ receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis. Arthritis Rheum 2006; 54: 3828–37., , , , , , et al.
- 43A shift in the balance of inhibitory and activating Fcγ receptors on monocytes toward the inhibitory Fcγ receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis. Arthritis Rheum 2004; 50: 3878–87., , , , , .