Dr. Naredo received honoraria (less than $10,000) from Abbott.
Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis
Article first published online: 27 MAR 2008
Copyright © 2008 by the American College of Rheumatology
Arthritis Care & Research
Volume 59, Issue 4, pages 515–522, 15 April 2008
How to Cite
Naredo, E., Rodríguez, M., Campos, C., Rodríguez-heredia, J. M., Medina, J. A., Giner, E., Martínez, O., Toyos, F. J., Ruíz, T., Ros, I., Pujol, M., Miquel, X., García, L., Aznar, J. J., Chamizo, E., Páez, M., Morales, P., Rueda, A., Tuneu, R., Corominas, H., de Agustín, J. J., Moragues, C., Mínguez, D., Willisch, A., González-cruz, I., Aragón, A., Iglesias, G., Armas, C., Pablo valdazo, J., Vargas, C., Calvo-alén, J., Juan-mas, A., Salvador, G., Puigdollers, A., Galíndez, E., Garrido, N., Salaberri, J., Raya, E., Salles, M., Díaz, C., Cuadra, J. l., Garrido, J. and Ultrasound group of the spanish society of rheumatology (2008), Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis. Arthritis & Rheumatism, 59: 515–522. doi: 10.1002/art.23529
- Issue published online: 27 MAR 2008
- Article first published online: 27 MAR 2008
- Manuscript Accepted: 1 OCT 2007
- Manuscript Received: 5 AUG 2007
- Abbott Laboratories
To investigate the validity, reproducibility, and responsiveness of a simplified power Doppler ultrasound (PDUS) assessment of joint inflammation compared with a comprehensive 44-joint PDUS assessment in patients with rheumatoid arthritis (RA) who started therapy with a biologic agent.
A total of 160 patients with active RA who started a biologic agent were prospectively recruited in 18 Spanish centers. The patients underwent clinical and laboratory assessment and blinded PDUS examination at baseline and 6 months. A PDUS examination of 128 synovial sites in 44 joints was performed. US synovitis and PD signal were semiquantitatively graded from 1 to 3 in all synovial sites. US count and index for synovitis and PD signal were obtained. PDUS intraobserver and interobserver reliability were evaluated. A process of data reduction based on the frequency of involvement of synovial sites by both synovitis and PD signal was conducted. Construct and discriminant validity of a simplified PDUS assessment was investigated.
A PDUS simplified assessment including 24 synovial sites from 12 joints detected 100% of patients with synovitis and 91% of patients with PD signal. There was a highly significant correlation between the 44-joint count and index for synovitis and PD signal and the 12-joint count and index for synovitis and PD signal at baseline and 6 months (r = 0.84–0.90, P < 0.0005). The smallest detectable difference was lower than the mean change in simplified PDUS variables.
A 12-joint PDUS assessment of RA joint inflammation may be a valid, feasible method for multicenter monitoring of therapeutic response to biologic agents.