Systemic Lupus Erythematosus

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Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus

  1. Aimee O. Hersh*,
  2. Emily von Scheven,
  3. Jinoos Yazdany,
  4. Pantelis Panopalis,
  5. Laura Trupin,
  6. Laura Julian,
  7. Patricia Katz†,
  8. Lindsey A. Criswell,
  9. Edward Yelin†

Article first published online: 30 DEC 2008

DOI: 10.1002/art.24091

Issue

Arthritis Care & Research

Arthritis Care & Research

Volume 61, Issue 1, pages 13–20, 15 January 2009

Additional Information

How to Cite

Hersh, A. O., von Scheven, E., Yazdany, J., Panopalis, P., Trupin, L., Julian, L., Katz, P., Criswell, L. A. and Yelin, E. (2009), Differences in long-term disease activity and treatment of adult patients with childhood- and adult-onset systemic lupus erythematosus. Arthritis & Rheumatism, 61: 13–20. doi: 10.1002/art.24091

Author Information

  1. University of California, San Francisco

  1. †

    Because Drs. Katz and Yelin are Editors of Arthritis Care & Research, review of this article was handled by the Editor of Arthritis & Rheumatism.

*Department of Pediatrics, University of California, San Francisco, 533 Parnassus Avenue, Box 0107, San Francisco, CA 94143

Publication History

  1. Issue published online: 30 DEC 2008
  2. Article first published online: 30 DEC 2008
  3. Manuscript Accepted: 9 SEP 2008
  4. Manuscript Received: 18 MAR 2008

Funded by

  • National Center for Research Resources of the US Public Health Service. Grant Number: 5-M01-RR-00079
  • NIH. Grant Number: T32-AR-0734
  • American College of Rheumatology Physician Scientist Development award
  • NIH through the Rosalind Russell Medical Research Center for Arthritis. Grant Numbers: K24-AR02175, R01-AR44804
  • State of California Lupus Fund
  • Arthritis Foundation
  • Agency for Healthcare Research and Quality
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases. Grant Numbers: 1-R01-HS013893, P60-AR053308

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REFERENCES

  • 1
    Arkachaisri T, Lehman TJ. Systemic lupus erythematosus and related disorders of childhood. Curr Opin Rheumatol 1999; 11: 384–92.
  • 2
    Abeles M, Urman JD, Weinstein A, Lowenstein M, Rothfield NF. Systemic lupus erythematosus in the younger patient: survival studies. J Rheumatol 1980; 7: 515–22.
  • 3
    Tucker LB, Menon S, Schaller JG, Isenberg DA. Adult- and childhood-onset systemic lupus erythematosus: a comparison of onset, clinical features, serology, and outcome. Br J Rheumatol 1995; 34: 866–72.
  • 4
    Ravelli A, Ruperto N, Martini A. Outcome in juvenile onset systemic lupus erythematosus. Curr Opin Rheumatol 2005; 17: 568–73.
  • 5
    Miettunen PM, Ortiz-Alvarez O, Petty RE, Cimaz R, Malleson PN, Cabral DA, et al. Gender and ethnic origin have no effect on longterm outcome of childhood-onset systemic lupus erythematosus. J Rheumatol 2004; 31: 1650–4.
  • 6
    Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271–7.
    Direct Link:
  • 7
    Carreno L, Lopez-Longo FJ, Monteagudo I, Rodriguez-Mahou M, Bascones M, Gonzalez CM, et al. Immunological and clinical differences between juvenile and adult onset of systemic lupus erythematosus. Lupus 1999; 8: 287–92.
  • 8
    Font J, Cervera R, Espinosa G, Pallares L, Ramos-Casals M, Jimenez S, et al. Systemic lupus erythematosus (SLE) in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis 1998; 57: 456–9.
  • 9
    Janwityanujit S, Totemchokchyakarn K, Verasertniyom O, Vanichapuntu M, Vatanasuk M. Age-related differences on clinical and immunological manifestations of SLE. Asian Pac J Allergy Immunol 1995; 13: 145–9.
  • 10
    Pande I, Sekharan NG, Kailash S, Uppal SS, Singh RR, Kumar A, et al. Analysis of clinical and laboratory profile in Indian childhood systemic lupus erythematosus and its comparison with SLE in adults. Lupus 1993; 2: 83–7.
  • 11
    Reichlin M, Faulkner Broyles T, Hubscher O, James J, Lehman TA, Palermo R, et al. Prevalence of autoantibodies to ribosomal P proteins in juvenile-onset systemic lupus erythematosus compared with the adult disease. Arthritis Rheum 1999; 42: 69–75.
    Direct Link:
  • 12
    Brunner HI, Bishnoi A, Barron AC, Houk LJ, Ware A, Farhey Y, et al. Disease outcomes and ovarian function of childhood-onset systemic lupus erythematosus. Lupus 2006; 15: 198–206.
  • 13
    Chalom EC, Periera B, Cole R, Rettig P, DeHoratius R, Athreya B. Educational, vocational and socioeconomic status and quality of life in adults with childhood-onset systemic lupus erythematosus (long term quality follow up data from a single pediatric center). Pediatr Rheumatol Online J 2004; 2: 207–26.
  • 14
    Tucker LB, Uribe AG, Fernandez M, Vila LM, McGwin G, Apte M, et al. Adolescent onset of lupus results in more aggressive disease and worse outcomes: results of a nested matched case-control study within LUMINA, a multiethnic US cohort (LUMINA LVII). Lupus 2008; 17: 314–22.
  • 15
    Swaak AJ, van den Brink HG, Smeenk RJ, Manger K, Kalden JR, Tosi S, et al. Systemic lupus erythematosus: disease outcome in patients with a disease duration of at least 10 years. Second evaluation. Lupus 2001; 10: 51–8.
  • 16
    Swaak AJ, van den Brink HG, Smeenk RJ, Manger K, Kalden JR, Tosi S, et al. Systemic lupus erythematosus: clinical features in patients with a disease duration of over 10 years, first evaluation. Rheumatology (Oxford) 1999; 38: 953–8.
  • 17
    Urowitz MB, Feletar M, Bruce IN, Ibanez D, Gladman DD. Prolonged remission in systemic lupus erythematosus. J Rheumatol 2005; 32: 1467–72.
  • 18
    Brunner HI, Silverman ED, To T, Bombardier C, Feldman BM. Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict disease damage. Arthritis Rheum 2002; 46: 436–44.
    Direct Link:
  • 19
    Ravelli A, Duarte-Salazar C, Buratti S, Reiff A, Bernstein B, Maldonado-Velazquez MR, et al. Assessment of damage in juvenile-onset systemic lupus erythematosus: a multicenter cohort study. Arthritis Rheum 2003; 49: 501–7.
    Direct Link:
  • 20
    Yelin E, Trupin L, Katz P, Criswell L, Yazdany J, Gillis J, et al. Work dynamics among persons with systemic lupus erythematosus. Arthritis Rheum 2007; 57: 56–63.
    Direct Link:
  • 21
    Thorburn CM, Prokunina-Olsson L, Sterba KA, Lum RF, Seldin MF, Alarcon-Riquelme ME, et al. Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes Immun 2007; 8: 279–87.
  • 22
    Karlson EW, Daltroy LH, Rivest C, Ramsey-Goldman R, Wright EA, Partridge AJ, et al. Validation of a Systemic Lupus Activity Questionnaire (SLAQ) for population studies. Lupus 2003; 12: 280–6.
  • 23
    Yazdany J, Yelin EH, Panopalis P, Trupin L, Julian L, Katz PP. Validation of the Systemic Lupus Erythematosus Activity Questionnaire in a large observational cohort. Arthritis Rheum 2008; 59: 136–43.
    Direct Link:
  • 24
    Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care 1996; 34: 220–33.
  • 25
    Cassidy J, Petty R. Textbook of pediatric rheumatology. 5th ed. Philadelphia: Elsevier Saunders; 2005.
  • 26
    Brunner HI, Gladman DD, Ibanez D, Urowitz MD, Silverman ED. Difference in disease features between childhood-onset and adult-onset systemic lupus erythematosus. Arthritis Rheum 2008; 58: 556–62.
    Direct Link:
  • 27
    McCurdy DK, Lehman TJ, Bernstein B, Hanson V, King KK, Nadorra R, et al. Lupus nephritis: prognostic factors in children. Pediatrics 1992; 89: 240–6.
  • 28
    Ardoin SP, Sandborg C, Schanberg LE. Management of dyslipidemia in children and adolescents with systemic lupus erythematosus. Lupus 2007; 16: 618–26.
  • 29
    Korkmaz C, Cansu DU, Kasifoglu T. Myocardial infarction in young patients (< or =35 years of age) with systemic lupus erythematosus: a case report and clinical analysis of the literature. Lupus 2007; 16: 289–97.
  • 30
    Becker-Merok A, Nossent HC. Damage accumulation in systemic lupus erythematosus and its relation to disease activity and mortality. J Rheumatol 2006; 33: 1570–7.
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