Osteoarthritis

You have full text access to this OnlineOpen article

Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis

  1. Shreyasee Amin1,†,*,
  2. Kristin Baker2,
  3. Jingbo Niu2,
  4. Margaret Clancy2,
  5. Joyce Goggins2,
  6. Ali Guermazi3,
  7. Mikayel Grigoryan4,
  8. David J. Hunter2,
  9. David T. Felson2

Article first published online: 30 DEC 2008

DOI: 10.1002/art.24182

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 60, Issue 1, pages 189–198, January 2009

Additional Information

How to Cite

Amin, S., Baker, K., Niu, J., Clancy, M., Goggins, J., Guermazi, A., Grigoryan, M., Hunter, D. J. and Felson, D. T. (2009), Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis. Arthritis & Rheumatism, 60: 189–198. doi: 10.1002/art.24182

Author Information

  1. 1

    Mayo Clinic, Rochester, Minnesota

  2. 2

    Boston University School of Medicine, Boston, Massachusetts

  3. 3

    Boston University School of Medicine, Boston, Massachusetts, and University of California, San Francisco

  4. 4

    University of California, San Francisco, and University of Iowa, Iowa City

  1. †

    Dr. Amin has received consulting fees, speaking fees, and/or honoraria from Merck (less than $10,000).

*Division of Rheumatology, College of Medicine, Mayo Clinic, Rochester, MN 55905

Publication History

  1. Issue published online: 30 DEC 2008
  2. Article first published online: 30 DEC 2008
  3. Manuscript Accepted: 25 SEP 2008
  4. Manuscript Received: 13 NOV 2007

Funded by

  • Arthritis Foundation (Osteoarthritis Biomarkers Grant)
  • NIH. Grant Number: AR-47785
  • Bayer Corporation

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (144K)

REFERENCES

  • 1
    Guccione AA, Felson DT, Anderson JJ, Anthony JM, Zhang Y, Wilson PW, et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health 1994; 84: 351–8.
  • 2
    Jones G, Nguyen T, Sambrook PN, Lord SR, Kelly PJ, Eisman JA. Osteoarthritis, bone density, postural stability, and osteoporotic fractures: a population based study. J Rheumatol 1995; 22: 921–5.
  • 3
    Slemenda C, Brandt KD, Heilman DK, Mazzuca S, Braunstein EM, Katz BP, et al. Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med 1997; 127: 97–104.
  • 4
    Fisher NM, Pendergast DR. Reduced muscle function in patients with osteoarthritis. Scand J Rehabil Med 1997; 29: 213–21.
  • 5
    Hurley MV, Scott DL, Rees J, Newham DJ. Sensorimotor changes and functional performance in patients with knee osteoarthritis. Ann Rheum Dis 1997; 56: 641–8.
  • 6
    Cheing GL, Hui-Chan CW. The motor dysfunction of patients with knee osteoarthritis in a Chinese population. Arthritis Rheum 2001; 45: 62–8.
    Direct Link:
  • 7
    Hassan BS, Mockett S, Doherty M. Static postural sway, proprioception, and maximal voluntary quadriceps contraction in patients with knee osteoarthritis and normal control subjects. Ann Rheum Dis 2001; 60: 612–8.
  • 8
    Lewek MD, Rudolph KS, Snyder-Mackler L. Quadriceps femoris muscle weakness and activation failure in patients with symptomatic knee osteoarthritis. J Orthop Res 2004; 22: 110–5.
    Direct Link:
  • 9
    McAlindon TE, Cooper C, Kirwan JR, Dieppe PA. Determinants of disability in osteoarthritis of the knee. Ann Rheum Dis 1993; 52: 258–62.
  • 10
    Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, et al. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum 1998; 41: 1951–9.
    Direct Link:
  • 11
    Brandt KD, Heilman DK, Slemenda C, Katz BP, Mazzuca SA, Braunstein EM, et al. Quadriceps strength in women with radiographically progressive osteoarthritis of the knee and those with stable radiographic changes. J Rheumatol 1999; 26: 2431–7.
  • 12
    Sharma L, Dunlop DD, Cahue S, Song J, Hayes KW. Quadriceps strength and osteoarthritis progression in malaligned and lax knees. Ann Intern Med 2003; 138: 613–9.
  • 13
    Sakai N, Luo ZP, Rand JA, An KN. The influence of weakness in the vastus medialis oblique muscle on the patellofemoral joint: an in vitro biomechanical study. ClinBiomech (Bristol, Avon) 2000; 15: 335–9.
  • 14
    Elias JJ, Bratton DR, Weinstein DM, Cosgarea AJ. Comparing two estimations of the quadriceps force distribution for use during patellofemoral simulation. J Biomech 2006; 39: 865–72.
  • 15
    Davies AP, Vince AS, Shepstone L, Donell ST, Glasgow MM. The radiologic prevalence of patellofemoral osteoarthritis. Clin Orthop Relat Res 2002; 402: 206–12.
  • 16
    Kornaat PR, Bloem JL, Ceulemans RY, Riyazi N, Rosendaal FR, Nelissen RG, et al. Osteoarthritis of the knee: association between clinical features and MR imaging findings. Radiology 2006; 239: 811–7.
  • 17
    Szebenyi B, Hollander AP, Dieppe P, Quilty B, Duddy J, Clarke S, et al. Associations between pain, function, and radiographic features in osteoarthritis of the knee. Arthritis Rheum 2006; 54: 230–5.
    Direct Link:
  • 18
    Baker KR, Xu L, Zhang Y, Nevitt M, Niu J, Aliabadi P, et al. Quadriceps weakness and its relationship to tibiofemoral and patellofemoral knee osteoarthritis in Chinese: the Beijing Osteoarthritis Study. Arthritis Rheum 2004; 50: 1815–21.
    Direct Link:
  • 19
    Hunter DJ, Zhang YQ, Tu X, Lavalley M, Niu JB, Amin S, et al. Change in joint space width: hyaline articular cartilage loss or alteration in meniscus? Arthritis Rheum 2006; 54: 2488–95.
    Direct Link:
  • 20
    Amin S, LaValley MP, Guermazi A, Grigoryan M, Hunter DJ, Clancy M, et al. The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis. Arthritis Rheum 2005; 52: 3152–9.
    Direct Link:
  • 21
    Felson DT, Chaisson CE, Hill CL, Totterman SM, Gale ME, Skinner KM, et al. The association of bone marrow lesions with pain in knee osteoarthritis. Ann Intern Med 2001; 134: 541–9.
  • 22
    Felson DT, McLaughlin S, Goggins J, LaValley MP, Gale ME, Totterman S, et al. Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 2003; 139: 330–6.
  • 23
    Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum 1986; 29: 1039–49.
    Direct Link:
  • 24
    Peterfy CG, Guermazi A, Zaim S, Tirman PF, Miaux Y, White D, et al. Whole-Organ Magnetic Resonance Imaging Score (WORMS) of the knee in osteoarthritis. Osteoarthritis Cartilage 2004; 12: 177–90.
  • 25
    Perrin DH. Interpreting an isokinetic evaluation. Isokinetic exercise and assessment. Champaign (IL): Human Kinetic Publishers; 1993. p. 59–72.
  • 26
    Moreland JR, Bassett LW, Hanker GJ. Radiographic analysis of the axial alignment of the lower extremity. J Bone Joint Surg Am 1987; 69: 745–9.
  • 27
    Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988; 15: 1833–40.
  • 28
    Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 1957; 16: 494–502.
  • 29
    Hurley MV. The role of muscle weakness in the pathogenesis of osteoarthritis. Rheum Dis Clin North Am 1999; 25: 283–98.
  • 30
    Jefferson RJ, Collins JJ, Whittle MW, Radin EL, O'Connor JJ. The role of the quadriceps in controlling impulsive forces around heel strike. Proc Inst Mech Eng [H] 1990; 204: 21–8.
  • 31
    Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA 2001; 286: 188–95.
  • 32
    Maurer BT, Stern AG, Kinossian B, Cook KD, Schumacher HR Jr. Osteoarthritis of the knee: isokinetic quadriceps exercise versus an educational intervention. Arch Phys Med Rehabil 1999; 80: 1293–9.
  • 33
    Fransen M, Crosbie J, Edmonds J. Physical therapy is effective for patients with osteoarthritis of the knee: a randomized controlled clinical trial. J Rheumatol 2001; 28: 156–64.
  • 34
    Quilty B, Tucker M, Campbell R, Dieppe P. Physiotherapy, including quadriceps exercises and patellar taping, for knee osteoarthritis with predominant patello-femoral joint involvement: randomized controlled trial. J Rheumatol 2003; 30: 1311–7.
  • 35
    Roddy E, Zhang W, Doherty M. Aerobic walking or strengthening exercise for osteoarthritis of the knee? A systematic review. Ann Rheum Dis 2005; 64: 544–8.
  • 36
    Ettinger WH Jr, Burns R, Messier SP, Applegate W, Rejeski WJ, Morgan T, et al. A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis: the Fitness Arthritis and Seniors Trial (FAST). JAMA 1997; 277: 25–31.
  • 37
    Mikesky AE, Mazzuca SA, Brandt KD, Perkins SM, Damush T, Lane KA. Effects of strength training on the incidence and progression of knee osteoarthritis. Arthritis Rheum 2006; 55: 690–9.
    Direct Link:
  • 38
    Amin S, Niu J, Guermazi A, Grigoryan M, Hunter DJ, Clancy M, et al. Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis. Ann Rheum Dis 2007; 66: 18–22.
View Full Article (HTML) Get PDF (144K)