Ms De Vera receives training support from the Canadian Arthritis Network, the Michael Smith Foundation for Health Research, and the Canadian Institutes of Health Research.
Gout and the risk of parkinson's disease: A cohort study
Article first published online: 30 OCT 2008
Copyright © 2008 by the American College of Rheumatology
Arthritis Care & Research
Volume 59, Issue 11, pages 1549–1554, 15 November 2008
How to Cite
De Vera, M., Rahman, M. M., Rankin, J., Kopec, J., Gao, X. and Choi, H. (2008), Gout and the risk of parkinson's disease: A cohort study. Arthritis & Rheumatism, 59: 1549–1554. doi: 10.1002/art.24193
- Issue published online: 30 OCT 2008
- Article first published online: 30 OCT 2008
- Manuscript Accepted: 26 JUN 2008
- Manuscript Received: 14 FEB 2008
Several studies have suggested that higher serum uric acid levels lead to a lower risk of Parkinson's disease (PD) because uric acid exerts antioxidant effects on neurons. Our objective was to examine the relationship between gout and the risk of PD in persons age ≥65 years.
We conducted a population-based cohort study using the British Columbia Linked Health Database and PharmaCare data (i.e., prescription drug data for those age ≥65 years). We compared incidence rates of PD between 11,258 gout patients and 56,199 controls matched on age, sex, date of gout diagnosis, and length of medical record. Cox proportional hazards models were used to estimate the relative risk (RR) of PD, adjusting for age, sex, prior comorbid conditions, and use of diuretics and nonsteroidal antiinflammatory drugs.
Over an 8-year median followup, we identified 1,182 new cases of PD. Compared with individuals without gout, the multivariate RR of PD among those with gout was 0.70 (95% confidence interval [95% CI] 0.59–0.83). In subgroup analyses, the inverse association was similarly present in both sexes and was evident among those who did not use diuretics (RR 0.66, 95% CI 0.54–0.81), but not among diuretic users (RR 0.80, 95% CI 0.58–1.10, P for interaction 0.35).
Our population-based data provide evidence for a protective effect of gout on the risk of PD and support the purported protective role of uric acid.