Osteoarthritis

You have full text access to this OnlineOpen article

Is obesity a risk factor for progressive radiographic knee osteoarthritis?

  1. J. Niu1,
  2. Y. Q. Zhang1,
  3. J. Torner2,
  4. M. Nevitt3,
  5. C. E. Lewis4,
  6. P. Aliabadi5,
  7. B. Sack1,
  8. M. Clancy1,
  9. L. Sharma6,
  10. D. T. Felson1,*

Article first published online: 26 FEB 2009

DOI: 10.1002/art.24337

Issue

Arthritis Care & Research

Arthritis Care & Research

Volume 61, Issue 3, pages 329–335, 15 March 2009

Additional Information

How to Cite

Niu, J., Zhang, Y. Q., Torner, J., Nevitt, M., Lewis, C. E., Aliabadi, P., Sack, B., Clancy, M., Sharma, L. and Felson, D. T. (2009), Is obesity a risk factor for progressive radiographic knee osteoarthritis?. Arthritis & Rheumatism, 61: 329–335. doi: 10.1002/art.24337

Author Information

  1. 1

    Boston University School of Medicine, Boston, Massachusetts

  2. 2

    University of Iowa, Iowa City

  3. 3

    University of California, San Francisco

  4. 4

    University of Alabama, Birmingham

  5. 5

    Brigham & Women's Hospital, Boston, Massachusetts

  6. 6

    Feinberg School of Medicine, Northwestern University, Chicago, Illinois

*Suite 200, 650 Albany Street, Boston University School of Medicine, Boston, MA 02118

Publication History

  1. Issue published online: 26 FEB 2009
  2. Article first published online: 26 FEB 2009
  3. Manuscript Accepted: 3 DEC 2008
  4. Manuscript Received: 19 AUG 2008

Funded by

  • NIH. Grant Number: AR-47785
  • National Institute on Aging. Grant Numbers: 1-U01-AG18832, 1-U01-AG19069, 1-U01-AG18947, 1-U01-AG18820
  • National Institute on Aging

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (123K)

REFERENCES

  • 1
    Dieppe PA, Cushnaghan J, Shepstone L. The Bristol ‘OA500’ study: progression of osteoarthritis (OA) over 3 years and the relationship between clinical and radiographic changes at the knee joint. Osteoarthritis Cartilage 1997; 5: 87–97.
  • 2
    Cooper C, Dieppe PA, Snow S, Kellingray S, Coggon D, Stuart B. Determinants of incidence and progression of radiographic knee osteoarthritis [abstract]. Arthritis Rheum 1997; 40: 1797.
  • 3
    Felson DT, McLaughlin S, Goggins J, Lavalley MP, Gale ME, Totterman S, et al. Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 2003; 139 (5 Pt 1): 330–6.
  • 4
    Dieppe P, Cushnaghan J, Tucker M, Browning S, Shepstone L. The Bristol 'OA500 study': progression and impact of the disease after 8 years. Osteoarthritis Cartilage 2000; 8: 63–8.
  • 5
    Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA 2001; 286: 188–95.
  • 6
    Felson DT, Goggins J, Niu J, Zhang Y, Hunter DJ. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum 2004; 50: 3904–9.
    Direct Link:
  • 7
    Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. Obesity and knee osteoarthritis: the Framingham Study. Ann Intern Med 1988; 109: 18–24.
  • 8
    Peterfy CG, Li J, Duryea J, Lynch JA, Miaux Y, Genant HK. Nonfluoroscopic method for flexed radiography of the knee that allows reproducible joint-space width measurement [abstract]. Arthritis Rheum 1998; 41: S361.
  • 9
    LaValley MP, McLaughlin S, Goggins J, Gale D, Nevitt MC, Felson DT. The lateral view radiograph for assessment of the tibiofemoral joint space in knee osteoarthritis: its reliability, sensitivity to change, and longitudinal validity. Arthritis Rheum 2005; 52: 3542–7.
    Direct Link:
  • 10
    Felson D, Nevitt MC, Yang M, Clancy M, Niu J, Torner JC, et al. A new approach yields high rates of x-ray progression in knee osteoarthritis. J Rheumatol 2008; 35: 2047–54.
  • 11
    Reijman M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis 2007; 66: 158–62.
  • 12
    Belo JN, Berger MY, Reijman M, Koes BW, Bierma-Zeinstra SM. Prognostic factors of progression of osteoarthritis of the knee: a systematic review of observational studies. Arthritis Rheum 2007; 57: 13–26.
    Direct Link:
  • 13
    Andriacchi TP. Dynamics of knee malalignment. Orthop Clin North Am 1994; 25: 395–403.
  • 14
    Hunter DJ, Niu J, Felson DT, Harvey WF, Gross KD, McCree P, et al. Knee alignment does not predict incident osteoarthritis: the Framingham osteoarthritis study. Arthritis Rheum 2007; 56: 1212–8.
    Direct Link:
  • 15
    Brouwer GM, van Tol AW, Bergink AP, Belo JN, Bernsen RM, Reijman M, et al. Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum 2007; 56: 1204–11.
    Direct Link:
  • 16
    Derek T, Cooke V, Kelly BP, Harrison L, Mohamed G, Khan B. Radiographic grading for knee osteoarthritis. A revised scheme that relates to alignment and deformity. J Rheumatol 1999; 26: 641–4.
  • 17
    Paradowski PT, Englund M, Lohmander LS, Roos EM. The effect of patient characteristics on variability in pain and function over two years in early knee osteoarthritis. Health Qual Life Outcomes 2005; 3: 59.
  • 18
    Messier SP, Loeser RF, Miller GD, Morgan TM, Rejeski WJ, Sevick MA, et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial. Arthritis Rheum 2004; 50: 1501–10.
    Direct Link:
  • 19
    Fransen M. Dietary weight loss and exercise for obese adults with knee osteoarthritis: modest weight loss targets, mild exercise, modest effects. Arthritis Rheum 2004; 50: 1366–69.
    Direct Link:
View Full Article (HTML) Get PDF (123K)