Editorial
You have full text access to this OnlineOpen article
When the levee doesn't break: A novel role of β2-glycoprotein I to protect against congenital heart block
Article first published online: 26 FEB 2009
DOI: 10.1002/art.24358
Copyright © 2009 by the American College of Rheumatology
Additional Information
How to Cite
Clancy, R. M. (2009), When the levee doesn't break: A novel role of β2-glycoprotein I to protect against congenital heart block. Arthritis & Rheumatism, 60: 636–638. doi: 10.1002/art.24358
Publication History
- Issue published online: 26 FEB 2009
- Article first published online: 26 FEB 2009
- Manuscript Accepted: 5 DEC 2008
- Manuscript Received: 12 NOV 2008
REFERENCES
- 1, , , , . Ro 60 functions as a receptor for β2-glycoprotein I on apoptotic cells. Arthritis Rheum 2009; 60: 860–9.
- 2. Antiphospholipid antibody. Babies, blood clots, biology. JAMA 1997; 277: 1549–51.
- 3, . A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors. Genes Dev 1994; 8: 2891–903.
- 4, , , , . Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell 2005; 121: 529–39.
- 5, , , , . Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen. Nat Struct Mol Biol 2006; 13: 1002–9.
- 6, , , , , . The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation. Curr Biol 2003; 13: 2206–11.
- 7, , . Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994; 179: 1317–30.
- 8, , , , , , et al. Accessibility of SSA/Ro and SSB/La antigens to maternal autoantibodies in apoptotic human fetal cardiac myocytes. J Immunol 1998; 161: 5061–9.
- 9, , , , , , et al. Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopes. Clin Exp Immunol 2007; 148: 153–60.
- 10, , , , , , et al. Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block. J Clin Invest 2006; 116: 2413–22.
- 11, , , , . Immunohistologic evidence supports apoptosis, IgG deposition, and novel macrophage/fibroblast crosstalk in the pathologic cascade leading to congenital heart block. Arthritis Rheum 2004; 50: 173–82.
- 12, , , , , , et al. Epitope specificity of monoclonal anti-beta 2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome. J Immunol 1995; 155: 1629–36.
- 13, , , . IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2–glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood 2005; 105: 1540–5.

1529-0131/asset/olbannerleft.gif?v=1&s=897b81612b4ad6cae003112184adc709261d5f61)
1529-0131/asset/olbannerright.gif?v=1&s=04654f5ea3cbb01656383e0c0d04b16fd0a9a896)
