Dr. Maradit Kremers has received consultant fees, speaking fees, and/or honoraria (less than $10,000) from Amgen.
Epidemiology and clinical characteristics of behçet's disease in the US: A population-based study
Article first published online: 29 APR 2009
Copyright © 2009 by the American College of Rheumatology
Arthritis Care & Research
Volume 61, Issue 5, pages 600–604, 15 May 2009
How to Cite
Calamia, K. T., Wilson, F. C., Icen, M., Crowson, C. S., Gabriel, S. E. and Kremers, H. M. (2009), Epidemiology and clinical characteristics of behçet's disease in the US: A population-based study. Arthritis & Rheumatism, 61: 600–604. doi: 10.1002/art.24423
- Issue published online: 29 APR 2009
- Article first published online: 29 APR 2009
- Manuscript Accepted: 16 JAN 2009
- Manuscript Received: 24 NOV 2008
- NIH. Grant Number: AR-30582
Behçet's disease (BD) is a rare, multisystem inflammatory disorder of unknown cause. Although well-documented in Eastern populations, epidemiologic data is scarce in North American countries. Here we describe the incidence and prevalence of BD in Olmsted County, Minnesota over 45 years.
We identified an incidence cohort of subjects age ≥18 years who had a clinical diagnosis of and/or fulfilled the International Study Group (ISG) criteria for BD from January 1, 1960 to January 1, 2005. Age- and sex-specific incidence and prevalence were estimated and age- and sex-adjusted to the 2000 US total population.
The study population was comprised of 13 subjects with BD; 11 fulfilled ISG criteria between 1960 and 2005. Mean ± SD age was 31 ± 9 years, and 69% were white. Point prevalence in 2000 was 5.2 per 100,000 population (95% confidence interval [95% CI] 0.64–9.84). The overall annual age- and sex-adjusted incidence of BD was 0.38 per 100,000 population (95% CI 0.17–0.59), with a higher incidence in women (0.51 per 100,000; 95% CI 0.17–0.84) than in men (0.26 per 100,000; 95% CI 0.004–0.52). Dermatologic lesions included oral ulcers (100%), genital ulcers (62%), erythema nodosum (46%), and papulopustular lesions (54%). Ocular lesions, vascular complications, and central nervous system involvement were present in 8, 3, and 3 subjects, respectively.
Our study shows an overall incidence of 0.38 per 100,000 population, which is comparable with other Western populations. The prevalence of 5.2 per 100,000 population is similar to estimates reported in Western countries, but lower than that in countries along the Silk Road.