Rheumatoid Arthritis Basic Science Studies

You have full text access to this OnlineOpen article

The α7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation

  1. Marjolein A. Van Maanen1,
  2. Susanne P. Stoof2,
  3. Esmerij P. Van Der Zanden1,
  4. Wouter J. De Jonge1,
  5. Richard A. Janssen3,†,
  6. David F. Fischer3,‡,
  7. Nick Vandeghinste4,
  8. Reginald Brys4,
  9. Margriet J. Vervoordeldonk2,§,
  10. Paul P. Tak1,§,*

Article first published online: 29 APR 2009

DOI: 10.1002/art.24470

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 60, Issue 5, pages 1272–1281, May 2009

Additional Information

How to Cite

Maanen, M. A. V., Stoof, S. P., Zanden, E. P. V. D., Jonge, W. J. D., Janssen, R. A., Fischer, D. F., Vandeghinste, N., Brys, R., Vervoordeldonk, M. J. and Tak, P. P. (2009), The α7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: A possible role for a key neurotransmitter in synovial inflammation. Arthritis & Rheumatism, 60: 1272–1281. doi: 10.1002/art.24470

Author Information

  1. 1

    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

  2. 2

    Academic Medical Center, University of Amsterdam, and Arthrogen BV, Amsterdam, The Netherlands

  3. 3

    BioFocus DPI, a Galapagos company, Leiden, The Netherlands

  4. 4

    Galapagos, Mechelen, Belgium

  1. †

    Dr. Janssen owns stock options in Galapagos.

  2. ‡

    Dr. Fischer owns stock and stock options in Galapagos.

  3. §

    Drs. Vervoordeldonk and Tak contributed equally to this work.

*Division of Clinical Immunology and Rheumatology, F4-218, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Publication History

  1. Issue published online: 29 APR 2009
  2. Article first published online: 29 APR 2009
  3. Manuscript Accepted: 31 JAN 2009
  4. Manuscript Received: 10 JUL 2008

Funded by

  • Top Institute Pharma. Grant Number: T1-215
  • Netherlands Organization for Scientific Research (grants NWO and VIDI)

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (346K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Christopher N. Banks, Pamela J. Lein, A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation, NeuroToxicology, 2012,

    CrossRef

  2. 2
    Sture Forsgren, Presence of ChAT mRNA and a very marked α7nAChR immunoreaction in the synovial lining layer of the knee joint, Life Sciences, 2012,

    CrossRef

  3. 3
    Jinhe Li, Suzanne L. Mathieu, Richard Harris, Jianguo Ji, David J. Anderson, John Malysz, William H. Bunnelle, Jeffrey F. Waring, Kennan C. Marsh, Anwar Murtaza, Lisa M. Olson, Murali Gopalakrishnan, Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists, Journal of Neuroimmunology, 2011, 239, 1-2, 37

    CrossRef

  4. 4
    Merouane Bencherif, Patrick M. Lippiello, Rudolf Lucas, Mario B. Marrero, Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases, Cellular and Molecular Life Sciences, 2010, 68, 6, 931

    CrossRef

  5. 5
    M. Westman, S. Saha, M. Morshed, J. Lampa, Lack of acetylcholine nicotine alpha 7 receptor suppresses development of collagen-induced arthritis and adaptive immunity, Clinical & Experimental Immunology, 2010, 162, 1
    Direct Link:
  6. 6
    Jean-Marc Waldburger, Gary S. Firestein, Regulation of Peripheral Inflammation by the Central Nervous System, Current Rheumatology Reports, 2010, 12, 5, 370

    CrossRef

  7. 7
    Elena Neumann, Stephanie Lefèvre, Birgit Zimmermann, Steffen Gay, Ulf Müller-Ladner, Rheumatoid arthritis progression mediated by activated synovial fibroblasts, Trends in Molecular Medicine, 2010, 16, 10, 458

    CrossRef

  8. 8
    Peng Zhang, Ling Qin, Ge Zhang, The potential application of nicotinic acetylcholine receptor agonists for the treatment of rheumatoid arthritis, Inflammation Research, 2010, 59, 6, 415

    CrossRef

  9. 9
    A. Bruchfeld, R. S. Goldstein, S. Chavan, N. B. Patel, M. Rosas-Ballina, N. Kohn, A. R. Qureshi, K. J. Tracey, Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis, Journal of Internal Medicine, 2010, 268, 1
    Direct Link:
View Full Article (HTML) Get PDF (346K)