Dr. Rudwaleit has received consulting fees from Abbott, Centocor, Schering-Plough, and Wyeth (less than $10,000 each), and speaking fees from Abbott, Centocor, Schering-Plough, Pfizer, Wyeth, and Merck, Sharp, and Dohme (less than $10,000 each).
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Spondylarthritis
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The early disease stage in axial spondylarthritis: Results from the german spondyloarthritis inception cohort†
Article first published online: 26 FEB 2009
DOI: 10.1002/art.24483
Copyright © 2009 by the American College of Rheumatology
Additional Information
How to Cite
Rudwaleit, M., Haibel, H., Baraliakos, X., Listing, J., Märker-Hermann, E., Zeidler, H., Braun, J. and Sieper, J. (2009), The early disease stage in axial spondylarthritis: Results from the german spondyloarthritis inception cohort. Arthritis & Rheumatism, 60: 717–727. doi: 10.1002/art.24483
- †
The German Spondyloarthritis Inception Cohort is supported by the German Ministry for Education and Research (BMBF) (grant FKZ 01G19946), as part of the German Competence Network in Rheumatology. Amgen, Centocor, Schering-Plough, and Wyeth have provided support equally since 2005, when BMBF funding was reduced as scheduled. Abbott Immunology has provided an equal part of the support since 2006.
Publication History
- Issue published online: 26 FEB 2009
- Article first published online: 26 FEB 2009
- Manuscript Accepted: 7 NOV 2008
- Manuscript Received: 14 APR 2008
Funded by
- German Ministry for Education and Research (BMBF). Grant Number: FKZ 01G19946
- Abstract
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Abstract
Objective
Ankylosing spondylitis (AS) is diagnosed late, because radiographs of the sacroiliac joints often do not show definite sacroiliitis at the time of disease onset. The aim of this study was to investigate whether patients without definite radiographically defined sacroiliitis, referred to as nonradiographic axial spondylarthritis (SpA), are different from patients with AS with regard to clinical manifestations and disease activity measures. Moreover, we sought to identify determinants of the development of radiographic sacroiliitis.
Methods
In a cross-sectional analysis of 462 patients, we compared 226 patients with nonradiographic axial SpA (symptom duration ≤5 years) and 236 patients with AS (symptom duration ≤10 years) who are participants in the German Spondyloarthritis Inception Cohort. Radiographs of the sacroiliac joints and the spine were assessed by 2 readers in a blinded manner. Logistic regression analysis was applied to identify parameters associated with structural damage.
Results
The 2 groups did not differ in the frequency of HLA–B27 positivity, inflammatory back pain, arthritis, enthesitis, and uveitis and had similar levels of disease activity, using measures such as the Bath Ankylosing Spondylitis Disease Activity Index. In both groups, HLA–B27 positivity determined the age at disease onset. Male sex (adjusted odds ratio [OR] 2.38, 95% confidence interval [95% CI] 1.19–4.73 [P = 0.014]) and an elevated C-reactive protein (CRP) level (adjusted OR 1.85, 95% CI 0.96–3.56 [P = 0.066]) were associated with radiographic sacroiliitis. In patients with AS, male sex and an elevated CRP level were also associated with the presence of syndesmophytes.
Conclusion
Clinical manifestations and disease activity measures are highly comparable between patients with early nonradiographic axial SpA and those with early AS, suggesting that these 2 entities are part of the same disease. Male sex and an elevated CRP level are associated with structural damage on radiographs, whereas HLA–B27 positivity determines the age at disease onset.