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Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

  1. Evangelos Evangelou1,
  2. Kay Chapman2,
  3. Ingrid Meulenbelt3,
  4. Fotini B. Karassa1,
  5. John Loughlin4,
  6. Andrew Carr2,
  7. Michael Doherty5,
  8. Sally Doherty5,
  9. Juan J. Gómez-Reino6,
  10. Antonio Gonzalez6,
  11. Bjarni V. Halldorsson7,†,
  12. Valdimar B. Hauksson8,
  13. Albert Hofman9,
  14. Deborah J. Hart10,
  15. Shiro Ikegawa11,
  16. Thorvaldur Ingvarsson12,
  17. Qing Jiang13,
  18. Ingileif Jonsdottir14,†,
  19. Helgi Jonsson15,
  20. Hanneke J. M. Kerkhof9,
  21. Margreet Kloppenburg3,
  22. Nancy E. Lane16,
  23. Jia Li17,
  24. Rik J. Lories18,
  25. Joyce B. J. van Meurs9,
  26. Annu Näkki19,
  27. Michael C. Nevitt20,
  28. Julio Rodriguez-Lopez6,
  29. Dongquan Shi13,
  30. P. Eline Slagboom3,
  31. Kari Stefansson14,†,
  32. Aspasia Tsezou21,
  33. Gillian A. Wallis22,
  34. Christopher M. Watson1,
  35. Tim D. Spector10,
  36. Andre G. Uitterlinden9,
  37. Ana M. Valdes10,
  38. John P. A. Ioannidis23,*

Article first published online: 28 MAY 2009

DOI: 10.1002/art.24524

Issue

Arthritis & Rheumatism

Arthritis & Rheumatism

Volume 60, Issue 6, pages 1710–1721, June 2009

Additional Information

How to Cite

Evangelou, E., Chapman, K., Meulenbelt, I., Karassa, F. B., Loughlin, J., Carr, A., Doherty, M., Doherty, S., Gómez-Reino, J. J., Gonzalez, A., Halldorsson, B. V., Hauksson, V. B., Hofman, A., Hart, D. J., Ikegawa, S., Ingvarsson, T., Jiang, Q., Jonsdottir, I., Jonsson, H., Kerkhof, H. J. M., Kloppenburg, M., Lane, N. E., Li, J., Lories, R. J., van Meurs, J. B. J., Näkki, A., Nevitt, M. C., Rodriguez-Lopez, J., Shi, D., Slagboom, P. E., Stefansson, K., Tsezou, A., Wallis, G. A., Watson, C. M., Spector, T. D., Uitterlinden, A. G., Valdes, A. M. and Ioannidis, J. P. A. (2009), Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis & Rheumatism, 60: 1710–1721. doi: 10.1002/art.24524

Author Information

  1. 1

    University of Ioannina School of Medicine, Ioannina, Greece

  2. 2

    University of Oxford, Oxford, UK

  3. 3

    Leiden University Medical Center, Leiden, The Netherlands

  4. 4

    Newcastle University, Newcastle upon Tyne, UK

  5. 5

    University of Nottingham and City Hospital Nottingham, Nottingham, UK

  6. 6

    Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain

  7. 7

    Reykjavik University and deCODE Genetics, Reykjavik, Iceland

  8. 8

    deCODE Genetics, Reykjavik, Iceland

  9. 9

    Erasmus Medical Center, Rotterdam, The Netherlands

  10. 10

    St. Thomas' Hospital and Kings College London, London, UK

  11. 11

    Center for Genomic Medicine, RIKEN, Tokyo, Japan

  12. 12

    University of Akureyri, Akureyri, and University of Iceland, Reykjavik, Iceland

  13. 13

    Drum Tower Hospital and Medical School of Nanjing University, Nanjing, Jiangsu, China

  14. 14

    University of Iceland, Reykjavik, and deCODE Genetics, Reykjavik, Iceland

  15. 15

    University of Iceland, Reykjavik, and Landspitali University Hospital, Reykjavik, Iceland

  16. 16

    University of California at Davis Medical Center, Sacramento, California

  17. 17

    Roche Molecular Systems, Pleasanton, California

  18. 18

    Katholieke Universiteit Leuven, Leuven, Belgium

  19. 19

    National Public Health Institute, ORTON Orthopedic Hospital, and ORTON Invalid Foundation, Helsinki, Finland

  20. 20

    University of California, San Francisco

  21. 21

    University of Thessaly Medical School, Larissa, Greece

  22. 22

    University of Manchester, Manchester, UK

  23. 23

    University of Ioannina Medical School of Medicine and Foundation for Research and Development–Hellas, Ioannina, Greece, and Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts

  1. †

    Drs. Halldorsson, Jonsdottir, and Stefansson own stock and/or stock options in deCODE Genetics.

*Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece

Publication History

  1. Issue published online: 28 MAY 2009
  2. Article first published online: 28 MAY 2009
  3. Manuscript Accepted: 17 FEB 2009
  4. Manuscript Received: 27 OCT 2008

Funded by

  • The TreatOA project is supported through Coordination Theme 1 (Health) of the European Union 7th Framework Programme. Grant Number: HEALTH-F2-2008-00
  • The GARP study is supported by Leiden University Medical Center
  • Dutch Arthritis Association
  • Pfizer, Groton, Connecticut
  • Netherlands Organization of Scientific Research. Grant Numbers: MW 904-61-095, 911-03-016, 917 66344, 911-03-012
  • Leiden University Medical Center
  • Center of Medical System Biology, Leiden, The Netherlands
  • NIH (National Institute on Aging). Grant Numbers: AG-05407, AR-35582, AG-05394, AR-35584, AR-35583, R01-AG-005407, R01-AG-027576-22, 2 R01-AG-005394-22A1, 2 R01-AG-027574-22A1), K24-AR-04884

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